A5101802063- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Reproductive System and Pregnancy
- Breast Cancer Treatment Studies
- Endometrial and Cervical Cancer Treatments
- Chemokine receptors and signaling
- Inflammatory mediators and NSAID effects
- Cancer Cells and Metastasis
- Endometriosis Research and Treatment
- Cervical and Thoracic Myelopathy
- Cancer Genomics and Diagnostics
- Immune Cell Function and Interaction
- Uterine Myomas and Treatments
- Medical and Health Sciences Research
- Cancer Risks and Factors
- Pelvic and Acetabular Injuries
- Cytokine Signaling Pathways and Interactions
- Estrogen and related hormone effects
- Cancer Immunotherapy and Biomarkers
- Pregnancy and preeclampsia studies
- Metastasis and carcinoma case studies
- Medical Imaging and Analysis
- Ectopic Pregnancy Diagnosis and Management
- Ovarian cancer diagnosis and treatment
- Pregnancy and Medication Impact
University Medical Center Freiburg
2015-2025
University of Freiburg
2015-2025
University Medical Center of the Johannes Gutenberg University Mainz
2023-2025
Johannes Gutenberg University Mainz
2023-2025
Olgahospital
2005-2024
München Klinik Harlaching
2020-2024
University Medical Center
2023
München Klinik
2007-2022
Klinik für Frauenheilkunde
1987-2021
Centrum für Integrierte Onkologie
2021
Extracellular ATP mediates numerous biological activities by interacting with plasma membrane P2 purinergic receptors. Recently, receptors have been described on dendritic cells (DC), but their functional role remains unclear. Proposed functions include improved Ag presentation, cytokine production, chemotaxis, and induction of apoptosis. We investigated the effects other receptor agonists endocytosis, phenotype, IL-12 secretion, T cell stimulatory capacity human monocyte-derived DC. found...
Triple-negative (TN) breast cancer is an aggressive subtype of associated with a unique set epidemiologic and genetic risk factors. We conducted two-stage genome-wide association study TN (stage 1: 1529 cases, 3399 controls; stage 2: 2148 1309 controls) to identify loci that influence risk. Variants in the 19p13.1 PTHLH showed significant associations (P < 5 × 10−8) 1 2 combined. Results also suggested substantial enrichment significantly variants among single nucleotide polymorphisms (SNPs)...
The prognostic relevance of circulating tumor cells (CTCs) at the time primary diagnosis has been well established. However, little information is available regarding their to follow-up care.The multicenter, open-label, phase III SUCCESS A trial compared two adjuvant chemotherapy regimens followed by 2 vs 5 years zoledronate for early-stage, high-risk breast cancer patients. presence CTCs was assessed before and after using FDA-approved CellSearch System. Overall survival (OS) disease-free...
Obese breast cancer patients have worse prognosis than normal weight patients, but the level at which obesity is prognostically unfavorable unclear. This retrospective analysis was performed using data from SUCCESS A trial, in 3754 with high-risk early were randomized to anthracycline- and taxane-based chemotherapy or without gemcitabine. Patients classified as underweight/normal (body mass index (BMI) < 25.0), overweight (BMI 25.0–29.9), slightly obese 30.0–34.9), moderately 35.0–39.9)...
Für die Sicherstellung einer fundierten frauenheilkundlichen Behandlung ist Weiterbildung von Ärztinnen und Ärzten in der Gynäkologie Geburtshilfe elementarer Bedeutung. Die "Weitblick"-Umfrage hatte zum Ziel, Weiterbildungsrealität Bayern online anhand eines anonymisierten Fragebogens zu erfassen.
Abstract The chemokine CCL22 is abundantly expressed in many types of cancer and instrumental for intratumoral recruitment regulatory T cells (Treg), an important subset immunosuppressive tumor-promoting lymphocytes. In this study, we offer evidence a generalized strategy to blunt Treg activity that can limit immune escape promote tumor rejection. Activation innate immunity with Toll-like receptor (TLR) or RIG-I–like (RLR) ligands prevented accumulation tumors by blocking their immigration....
Abstract Background Patient safety is a key target in public health, health services and medicine. Communication between all parties involved gynecology obstetrics (clinical staff/professionals, expectant mothers/patients their partners, close relatives or friends providing social support) should be improved to ensure patient safety, including the avoidance of preventable adverse events (pAEs). Therefore, interventions an app will developed this project through participatory approach...
Abstract Background Progress in medicine involves the structured analysis and communication of errors. Comparability between individual disciplines is only possible to a limited extent obstetrics plays special role: expectation self-determined joyful event meets with possibly serious complications highly complex care situations. This must be managed by an interdisciplinary team increasingly condensed workload. Adverse events cannot completely controlled. However, taking controllable risk...
Breast cancer is the most common female cancer, affecting approximately one in eight women during their lifetime North America and Europe. Receptor Activator of NF-kB Ligand (RANKL), its receptor RANK natural antagonist osteoprotegerin (OPG) are essential regulators bone resorption. We have initially shown that RANKL/RANK for hormone-driven mammary epithelial proliferation pregnancy been implicated stem cell biology. Using genetic mouse-models, we others identified system as a key regulator...
Citation Toth B, Haufe T, Scholz C, Kuhn Friese K, Karamouti M, Makrigiannakis A, Jeschke U. Placental Interleukin‐15 expression in recurrent miscarriage. Am J Reprod Immunol 2010; 64: 402–410 Problem Cytokines play a fundamental role at the feto–maternal interface. A dysregulation of cytokine profile could be linked with fetal rejection. This study investigated differences Th1 interleukin‐15 (IL‐15) normal and disturbed pregnancy. Method Analysis IL‐15 by immunohistochemistry real‐time...
Abstract Design Prospective diagnostic study. Objectives Anatomical evaluation and graduation of the severity spinal stenosis is essential in degenerative cervical spine disease. In clinical practice, this subjectively categorized on MRI lacking an objective reliable classification. We implemented a fully-automated quantification canal compromise through 3D T2-weighted segmentation. Setting Medical Center - University Freiburg, Germany. Methods Evaluation 202 participants receiving spine....
Problem Successful mammalian pregnancy requires a delicate immunological balance at the feto‐maternal interface that allows semi‐allogeneic fetus to grow, while protecting mother and child from environmental pathogens. As in other mucosal tissues, antigen‐recognition ‐handling by professional antigen‐presenting cells such as dendritic (DC) determine course of subsequent immune response. DC help shape this equilibrium. Endometrial tissue secretes high quantities glycodelin A (GdA) during...
Purpose . To assess the frequency, risk factors, and management of accidental durotomy in minimally invasive transforaminal lumbar interbody fusion (MIS TLIF). Methods This single‐center study retrospectively investigates 372 patients who underwent MIS TLIF were mobilized within 24 hours after surgery. The frequency durotomies, intraoperative closure technique, body mass index, history previous surgery was recorded. Results We identified 32 durotomies 514 levels (6.2%). Analysis showed a...
The aim of the study was to investigate safety and efficacy minimally invasive tubular microdiscectomy for treatment recurrent lumbar disc herniation (LDH). As opposed endoscopic techniques, namely microendoscopic transforaminal discectomy, this microscopically assisted technique has never been used LDH.Thirty consecutive patients who underwent LDH were included in study. preoperative postoperative visual analog scale (VAS) scores pain, clinical outcome according modified Macnab criteria,...