Stefan P. Renner
A5022202390- Endometriosis Research and Treatment
- Uterine Myomas and Treatments
- Endometrial and Cervical Cancer Treatments
- Gynecological conditions and treatments
- Ovarian cancer diagnosis and treatment
- Reproductive System and Pregnancy
- Medical and Health Sciences Research
- Health and Medical Studies
- Urological Disorders and Treatments
- BRCA gene mutations in cancer
- Intestinal and Peritoneal Adhesions
- Cancer Risks and Factors
- Global Cancer Incidence and Screening
- Social and Demographic Issues in Germany
- Reproductive Biology and Fertility
- Breast Cancer Treatment Studies
- Cervical Cancer and HPV Research
- Prenatal Screening and Diagnostics
- HER2/EGFR in Cancer Research
- Mobile Health and mHealth Applications
- Intraperitoneal and Appendiceal Malignancies
- Pelvic floor disorders treatments
- Ectopic Pregnancy Diagnosis and Management
- Genital Health and Disease
- Urologic and reproductive health conditions
Friedrich-Alexander-Universität Erlangen-Nürnberg
2012-2025
Klinikum Sindelfingen-Böblingen
2018-2025
Klinikverbund Südwest
2018-2024
Zentrum für Seelische Gesundheit
2022
Klinik für Frauenheilkunde
2021
Hewlett-Packard (Germany)
2021
Universitätsklinikum Erlangen
2011-2020
Comprehensive Cancer Center Erlangen
2012-2020
Bayreuth Medical Center
2019
Olgahospital
2015-2016
The Mayer-Rokitansky-Kuester-Hauser (MRKH) syndrome is a malformation of the female genitals (occurring in one 4000 live births) as result interrupted embryonic development Müllerian (paramesonephric) ducts. This retrospective study examined issue associated malformations, subtyping, and frequency distribution subtypes MRKH syndrome.Fifty-three patients were investigated using newly developed standardized questionnaire. Together with results clinical diagnostic examinations, classified into...
HNF1B is overexpressed in clear cell epithelial ovarian cancer, and we observed epigenetic silencing serous leading us to hypothesize that variation this gene differentially associates with cancer risk according histological subtype. Here comprehensively map respect analyse DNA methylation expression profiles across subtypes. Different single-nucleotide polymorphisms associate invasive (rs7405776 odds ratio (OR)=1.13, P=3.1 × 10−10) (rs11651755 OR=0.77, P=1.6 10−8) cancer. Risk alleles for...
Triple-negative (TN) breast cancer is an aggressive subtype of associated with a unique set epidemiologic and genetic risk factors. We conducted two-stage genome-wide association study TN (stage 1: 1529 cases, 3399 controls; stage 2: 2148 1309 controls) to identify loci that influence risk. Variants in the 19p13.1 PTHLH showed significant associations (P < 5 × 10−8) 1 2 combined. Results also suggested substantial enrichment significantly variants among single nucleotide polymorphisms (SNPs)...
ObjectiveTo harmonize standard operating procedures (SOPs) and standardize the recording of associated data for collection, processing, storage human tissues relevant to endometriosis.DesignAn international collaboration involving 34 clinical/academic centers three industry collaborators from 16 countries on five continents.SettingIn 2013, two workshops were conducted followed by global consultation, bringing together 54 leaders in endometriosis research sample processing around...
Abstract Background The aim of this retrospective study was to describe the spectrum genital and associated malformations in women with Mayer-Rokitansky-Küster-Hauser syndrome using evaluated diagnostic procedures Vagina Cervix Uterus Adnex – Malformation classification system (VCUAM). Methods 290 MRKH were clinically clinical examinations, abdominal perineal/rectal ultrasound, MRI, laparoscopy. Results Classification female malformation according possible 284 (97.9%). Complete atresia (V5b)...
<h3>Background</h3> Congenital malformations involving the Müllerian ducts are observed in around 5% of infertile women. Complete aplasia uterus, cervix, and upper vagina, also termed or Mayer–Rokitansky–Kuster–Hauser (MRKH) syndrome, occurs with an incidence 1 4500 female births, both isolated syndromic forms. Previous reports have suggested that a proportion cases, especially caused by variation copy number at different genomic loci. <h3>Methods</h3> In order to obtain overview...
Abstract STUDY QUESTION Does linzagolix administered orally once daily for up to 3 months at a dose of 75 mg alone or 200 in combination with add-back therapy (ABT) (1.0 estradiol; 0.5 norethindrone acetate, also known as norethisterone acetate [NETA]) demonstrate better efficacy than placebo the management endometriosis-related dysmenorrhea and non-menstrual pelvic pain? SUMMARY ANSWER Combining ABT was found significantly reduce pain therapy, while yielded significant decrease only months....
In this guideline, recommendations and standards for optimum diagnosis treatment of endometriosis are presented. They based on the analysis available scientific evidence as published in prospective randomized retrospective studies well systematic reviews. The guideline working group consisted experts from Austria, Germany, Switzerland, Czech Republic.
Abstract Blood lipids have been associated with the development of a range cancers, including breast, lung and colorectal cancer. For endometrial cancer, observational studies reported inconsistent associations between blood cancer risk. To reduce biases from unmeasured confounding, we performed bidirectional, two‐sample Mendelian randomization analysis to investigate relationship levels three (low‐density lipoprotein [LDL] high‐density [HDL] cholesterol, triglycerides) Genetic variants each...
Abstract Aims The aim of this official guideline published and coordinated by the German Society Gynaecology Obstetrics (DGGG) in cooperation with Austrian for (OEGGG) Swiss (SGGG) was to provide consensus-based recommendations diagnosis treatment endometriosis based on an evaluation relevant literature. Methods This S2k represents structured consensus a representative panel experts different professional backgrounds commissioned Guideline Committee DGGG, OEGGG SGGG. Recommendations...
To evaluate blood-based biomarkers to detect endometriosis and/or adenomyosis across nine European centers (June 2014-April 2018).This prospective, non-interventional study assessed the diagnostic accuracy of 54 biomarker immunoassays in samples from 919 women (aged 18-45 years) with suspicion versus symptomatic controls. Endometriosis was stratified by revised American Society for Reproductive Medicine stage. Symptomatic controls were "pathologic controls" or "pathology-free controls". The...
Common variants in the hepatocyte nuclear factor 1 homeobox B (HNF1B) gene are associated with risk of Type II diabetes and multiple cancers. Evidence to date indicates that cancer may be mediated via genetic or epigenetic effects on HNF1B expression. We previously found single-nucleotide polymorphisms (SNPs) at locus endometrial cancer, now report extensive fine-mapping silico laboratory analyses this locus. Analysis 1184 genotyped imputed SNPs 6608 Caucasian cases 37 925 controls, 895...
The appropriate surgical technique to treat patients with uterine fibroids is still a matter of debate as the potential risk incorrect treatment if histological examination detects sarcoma instead fibroids. published epidemiology for set against incidence accidental findings during surgery International comments on this topic are discussed and incorporated into assessment by German Society Gynecology Obstetrics (DGGG). ICD-O-3 version 2003 was used anatomical topographical coding sarcomas,...
The advantages and disadvantages of the various surgical techniques for hysterectomy are currently a topic debate, with particular controversy over leaving cervix in situ laparoscopic supracervical (LASH) procedure.In retrospective single-center study, medical history clinical characteristics were compared patients who had undergone benign disease period 2002-2008 at Department Obstetrics Gynecology, Erlangen University Hospital. Postoperative satisfaction frequency secondary operations...