Deborah J. Thompson

ORCID: 0000-0003-1465-5799
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About
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Research Areas
  • BRCA gene mutations in cancer
  • Genetic Associations and Epidemiology
  • Cancer-related molecular mechanisms research
  • Genetic factors in colorectal cancer
  • Digital Radiography and Breast Imaging
  • Nutrition, Genetics, and Disease
  • AI in cancer detection
  • Endometrial and Cervical Cancer Treatments
  • Global Cancer Incidence and Screening
  • Ovarian cancer diagnosis and treatment
  • Cancer Risks and Factors
  • Bioinformatics and Genomic Networks
  • RNA Research and Splicing
  • Epigenetics and DNA Methylation
  • Colorectal Cancer Screening and Detection
  • Genomic variations and chromosomal abnormalities
  • Cancer Genomics and Diagnostics
  • Estrogen and related hormone effects
  • Reproductive System and Pregnancy
  • Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
  • Cardiovascular Disease and Adiposity
  • Breast Cancer Treatment Studies
  • DNA Repair Mechanisms
  • Health, Environment, Cognitive Aging
  • Gene expression and cancer classification

University College London
2012-2025

Imperial College Healthcare NHS Trust
2025

University of Cambridge
2015-2024

Genomics (United Kingdom)
2022-2024

Acumen (United States)
2022

Wake Forest University
2022

Cancer Research UK Cambridge Center
2014-2021

MRC Epidemiology Unit
2003-2020

UC Irvine Health
2019

University of California, Irvine
2011-2019

Douglas F. Easton Karen A. Pooley Alison M. Dunning Paul D.P. Pharoah Deborah J. Thompson and 95 more Dennis G. Ballinger Jeffery P. Struewing Jonathan J. Morrison Helen I. Field Robert Luben Nicholas J. Wareham Shahana Ahmed Catherine S. Healey Richard Bowman Craig Luccarini Don Conroy Mitul Shah Hannah Munday Clare Jordan Barbara Perkins Judy West Karen Redman Kristy Driver Kerstin B. Meyer Christopher A. Haiman Laurence Kolonel Brian E. Henderson Loı̈c Le Marchand Paul Brennan Suleeporn Sangrajrang Valérie Gaborieau Fabrice Odefrey Chen‐Yang Shen Pei‐Ei Wu Hui‐Chun Wang Diana Eccles D. Gareth Evans Julian Peto Olivia Fletcher Nichola Johnson Sheila Seal Michael R. Stratton Nazneen Rahman Georgia Chenevix‐Trench Stig E. Bojesen Børge G. Nordestgaard C. K. Axelsson Montserrat García‐Closas Louise A. Brinton Stephen J. Chanock Jolanta Lissowska Beata Pepłońska Heli Nevanlinna Rainer Fagerholm Hannaleena Eerola Daehee Kang Keun-Young Yoo Dong‐Young Noh Sei Hyun Ahn David J. Hunter Susan E. Hankinson David G. Cox Per Hall Sara Wedrén Jianjun Liu Yen-Ling Low Natalia Bogdanova Peter Schürmann Thilo Dörk Rob A.�E.�M. Tollenaar Catharina E. Jacobi Peter Devilee Jan G.M. Klijn Alice J. Sigurdson Michele M. Doody Bruce H. Alexander Jinghui Zhang Angela Cox Ian W. Brock Gordon R. Macpherson Malcolm Reed Fergus J. Couch Ellen L. Goode Janet E. Olson Hanne Meijers‐Heijboer Ans van den Ouweland André G. Uitterlinden Fernando Rivadeneira Roger L. Milne Glòria Ribas Anna González‐Neira Javier Benı́tez John L. Hopper Margaret McCredie Melissa C. Southey Graham G. Giles Chris Schroen Christina Justenhoven Hiltrud Brauch Ute Hamann

10.1038/nature05887 article EN Nature 2007-05-27
John R. B. Perry Felix R. Day Cathy E. Elks Patrick Sulem Deborah J. Thompson and 95 more Teresa Ferreira Chunyan He Daniel I. Chasman Tõnu Esko Guðmar Þorleifsson Eva Albrecht Wei Ang Tanguy Corre Diana L. Cousminer Bjarke Feenstra Nora Franceschini Andrea Ganna Andrew D. Johnson Sanela Kjellqvist Kathryn L. Lunetta George McMahon Ilja M. Nolte Lavinia Paternoster Eleonora Porcu Albert V. Smith Lisette Stolk Alexander Teumer Natalia Tšernikova Emmi Tikkanen Sheila Ulivi Erin K. Wagner Najaf Amin Laura J. Bierut Enda M. Byrne Jouke‐Jan Hottenga Daniel L. Koller Massimo Mangino Tune H. Pers Laura M. Yerges-Armstrong Jing Hua Zhao Irene L. Andrulis Hoda Anton‐Culver Femke Atsma Stefania Bandinelli Matthias W. Beckmann Javier Benı́tez Carl Blomqvist Stig E. Bojesen Manjeet K. Bolla Bernardo Bonanni Hiltrud Brauch Hermann Brenner Julie E. Buring Jenny Chang‐Claude Stephen J. Chanock Jinhui Chen Georgia Chenevix‐Trench J. Margriet Collée Fergus J. Couch David Couper Andrea D. Coviello Angela Cox Kamila Czene Pio D’Adamo George Davey Smith Immaculata De Vivo Ellen W. Demerath Joe Dennis Peter Devilee Aida Karina Dieffenbach Alison M. Dunning Guðný Eiríksdóttir Johan G. Eriksson Peter A. Fasching Luigi Ferrucci Dieter Flesch‐Janys Henrik Flyger Tatiana Foroud Lude Franke Melissa E. Garcia Montserrat García‐Closas Frank Geller Eco J. C. de Geus Graham G. Giles Daníel F. Guðbjartsson Vilmundur Guðnason Pascal Guénel Suiqun Guo Per Hall Ute Hamann Robin Haring Catharina A. Hartman Andrew C. Heath Albert Hofman Maartje J. Hooning John L. Hopper Frank B. Hu David J. Hunter David Karasik Douglas P. Kiel

10.1038/nature13545 article EN Nature 2014-07-23
Felix R. Day Deborah J. Thompson Hannes Helgason Daniel I. Chasman Hilary K. Finucane and 95 more Patrick Sulem Katherine S. Ruth Sean Whalen Abhishek Sarkar Eva Albrecht Elisabeth Altmaier Marzyeh Amini Caterina Barbieri Thibaud Boutin Archie Campbell Ellen W. Demerath Ayush Giri Chunyan He Jouke‐Jan Hottenga Robert Karlsson Ivana Kolčić Po−Ru Loh Kathryn L. Lunetta Massimo Mangino Marco Brumat George McMahon Sarah E. Medland Ilja M. Nolte Raymond Noordam Teresa Nutile Lavinia Paternoster Natalia Perjakova Eleonora Porcu Lynda M. Rose Katharina E. Schraut Ayellet V. Segrè Albert V. Smith Lisette Stolk Alexander Teumer Irene L. Andrulis Stefania Bandinelli Matthias W. Beckmann Javier Benı́tez Sven Bergmann Murielle Bochud Eric Boerwinkle Stig E. Bojesen Manjeet K. Bolla Judith S. Brand Hiltrud Brauch Hermann Brenner Linda Broer Thomas Brüning Julie E. Buring Harry Campbell Eulalia Catamo Stephen J. Chanock Georgia Chenevix‐Trench Tanguy Corre Fergus J. Couch Diana L. Cousminer Angela Cox Laura Crisponi Kamila Czene George Davey Smith Eco J. C. de Geus Renée de Mutsert Immaculata De Vivo Joe Dennis Peter Devilee Isabel dos‐Santos‐Silva Alison M. Dunning Johan G. Eriksson Peter A. Fasching Lindsay Fernández‐Rhodes Luigi Ferrucci Dieter Flesch‐Janys Lude Franke Marike Gabrielson Ilaria Gandin Graham G. Giles Harald Grallert Daníel F. Guðbjartsson Pascal Guénel Per Hall Emily Hallberg Ute Hamann Tamara B. Harris Catharina A. Hartman Gerardo Heiss Maartje J. Hooning John L. Hopper Frank B. Hu David J. Hunter M. Arfan Ikram Hae Kyung Im Marjo‐Riitta Järvelin Peter K. Joshi David Karasik Manolis Kellis

10.1038/ng.3841 article EN Nature Genetics 2017-04-24

Homozygous or compound heterozygous mutations in the ATM gene are principal cause of ataxia telangiectasia (A-T). Several studies have suggested that carriers at increased risk breast cancer and perhaps other cancers, but precise is uncertain.Cancer incidence mortality information for 1160 relatives 169 UK A-T patients (including 247 obligate carriers) was obtained through National Health Service Central Registry. Relative risks (RRs) carriers, allowing genotype uncertainty, were estimated...

10.1093/jnci/dji141 article EN JNCI Journal of the National Cancer Institute 2005-05-31

10.1086/318181 article EN publisher-specific-oa The American Journal of Human Genetics 2001-02-01
Philip Haycock Stephen Burgess Aayah Nounu Jie Zheng George N. Okoli and 95 more Jack Bowden Kaitlin H. Wade Nicholas J. Timpson David M. Evans Peter Willeit Abraham Aviv Tom R. Gaunt Gibran Hemani Massimo Mangino Hayley Ellis Kathreena M. Kurian Karen A. Pooley Rosalind A. Eeles Jeffrey E. Lee Shenying Fang Wei V. Chen Matthew H. Law Lisa Bowdler Mark M. Iles Qiong Yang Bradford B. Worrall Hugh S. Markus Rayjean J. Hung Chris Amos Amanda B. Spurdle Deborah J. Thompson Tracy A. O’Mara Brian M. Wolpin Laufey T. Ámundadóttir Rachael Z. Stolzenberg‐Solomon Antonia Trichopoulou N. Charlotte Onland‐Moret Eiliv Lund Eric J. Duell Federico Canzian Gianluca Severi Kim Overvad Marc J. Gunter ­Rosario ­Tumino Ulrika Svenson André van Rij Annette F. Baas Matthew J. Bown Nilesh J. Samani Femke N.G. van t’Hof Gerard Tromp Gregory T. Jones Helena Kuivaniemi James R. Elmore Mattias Johansson James McKay Ghislaine Scélo Robert Carreras‐Torres Valérie Gaborieau Paul Brennan Paige M. Bracci Rachel Ε. Neale Sara H. Olson Steven Gallinger Donghui Li Gloria M. Petersen Harvey A. Risch Alison P. Klein Jiali Han Christian C. Abnet Neal D. Freedman Philip R. Taylor John M. Maris Katja K.H. Aben Lambertus A. Kiemeney Sita H. Vermeulen John K. Wiencke Kyle M. Walsh Margaret Wrensch Terri Rice Clare Turnbull Kevin Litchfield Lavinia Paternoster Marie Standl Gonçalo R. Abecasis John Paul SanGiovanni Yong Li Vladan Mijatovic Yadav Sapkota Siew‐Kee Low Krina T. Zondervan Grant W. Montgomery Dale R. Nyholt David A. van Heel Karen A. Hunt Dan E. Arking Foram N. Ashar Nona Sotoodehnia Daniel Woo Jonathan Rosand

The causal direction and magnitude of the association between telomere length incidence cancer non-neoplastic diseases is uncertain owing to susceptibility observational studies confounding reverse causation.

10.1001/jamaoncol.2016.5945 article EN JAMA Oncology 2017-02-27
Felix R. Day Katherine S. Ruth Deborah J. Thompson Kathryn L. Lunetta Natalia Pervjakova and 95 more Daniel I. Chasman Lisette Stolk Hilary K. Finucane Patrick Sulem Brendan Bulik‐Sullivan Tõnu Esko Andrew D. Johnson Cathy E. Elks Nora Franceschini Chunyan He Elisabeth Altmaier Jennifer A. Brody Lude Franke Jennifer E. Huffman Margaux F. Keller Patrick F. McArdle Teresa Nutile Eleonora Porcu Antonietta Robino Lynda M. Rose Ursula M. Schick Jennifer A. Smith Alexander Teumer Michela Traglia Dragana Vuckovic Jie Yao Wei Zhao Eva Albrecht Najaf Amin Tanguy Corre Jouke‐Jan Hottenga Massimo Mangino Albert V. Smith Toshiko Tanaka Gonçalo R. Abecasis Irene L. Andrulis Hoda Anton‐Culver Antonis C. Antoniou Volker Arndt Alice M. Arnold Caterina Barbieri Matthias W. Beckmann Alicia Beeghly‐Fadiel Javier Benı́tez Leslie Bernstein Suzette J. Bielinski Carl Blomqvist Eric Boerwinkle Natalia Bogdanova Stig E. Bojesen Manjeet K. Bolla Anne‐Lise Børresen‐Dale Thibaud Boutin Hiltrud Brauch Hermann Brenner Thomas Brüning Barbara Burwinkel Archie Campbell Harry Campbell Stephen J. Chanock J. Ross Chapman Yii-Der Ida Chen Georgia Chenevix‐Trench Fergus J. Couch Andrea D. Coviello Angela Cox Kamila Czene Hatef Darabi Immaculata De Vivo Ellen W. Demerath Joe Dennis Peter Devilee Thilo Dörk Isabel dos‐Santos‐Silva Alison M. Dunning John D. Eicher Peter A. Fasching Jessica D. Faul Jonine D. Figueroa Dieter Flesch‐Janys Ilaria Gandin Melissa E. Garcia Montserrat García‐Closas Graham G. Giles Giorgia Girotto Mark S. Goldberg Anna González‐Neira Mark O. Goodarzi Megan L. Grove Daníel F. Guðbjartsson Pascal Guénel Xiuqing Guo Christopher A. Haiman Per Hall Ute Hamann

10.1038/ng.3412 article EN Nature Genetics 2015-09-28
Katherine S. Ruth Felix R. Day Jazib Hussain Ana Martínez-Marchal Catherine Aiken and 95 more Ajuna Azad Deborah J. Thompson Lucie Knoblochová Hironori Abe Jane L. Tarry‐Adkins Javier Martín‐González Pierre Fontanillas Annique Claringbould Olivier B. Bakker Patrick Sulem Robin Walters Chikashi Terao Sandra Turon Momoko Horikoshi Kuang Lin N. Charlotte Onland‐Moret Aditya Sankar Emil Peter Thrane Hertz Pascal Timshel Vallari Shukla Rehannah Borup Kristina Wendelboe Olsen Paula Aguilera Mònica Ferrer‐Roda Yan Huang Stasa Stankovic Paul R. H. J. Timmers Thomas U. Ahearn Behrooz Z. Alizadeh Elnaz Naderi Irene L. Andrulis Alice M. Arnold Kristan J. Aronson Annelie Augustinsson Stefania Bandinelli Caterina Barbieri Robin N. Beaumont Heiko Becher Matthias W. Beckmann Stefania Benónísdóttir Sven Bergmann Murielle Bochud Eric Boerwinkle Stig E. Bojesen Manjeet K. Bolla Dorret I. Boomsma Nicholas Bowker Jennifer A. Brody Linda Broer Julie E. Buring Archie Campbell Harry Campbell Jose E. Castelao Eulalia Catamo Stephen J. Chanock Georgia Chenevix‐Trench Marina Ciullo Tanguy Corre Fergus J. Couch Angela Cox Laura Crisponi Simon S. Cross Francesco Cucca Kamila Czene George Davey Smith Eco J. C. de Geus Renée de Mutsert Immaculata De Vivo Ellen W. Demerath Joe Dennis Alison M. Dunning Miriam Dwek Mikael Eriksson Tõnu Esko Peter A. Fasching Jessica D. Faul Luigi Ferrucci Nora Franceschini Timothy M. Frayling Manuela Gago‐Dominguez Massimo Mezzavilla Montserrat García‐Closas Christian Gieger Graham G. Giles Harald Grallert Daníel F. Guðbjartsson Vilmundur Guðnason Pascal Guénel Christopher A. Haiman Niclas Håkansson Per Hall Caroline Hayward Chunyan He Wei He Gerardo Heiss

10.1038/s41586-021-03779-7 article EN Nature 2021-08-04

Abstract Mendelian randomization is the use of genetic variants as instrumental variables to estimate causal effects risk factors on outcomes. The total effect a factor change in outcome resulting from intervening factor. This may potentially encompass multiple mediating mechanisms. For proposed mediator, direct factor, keeping mediator constant. A difference between and indicates that pathway acts at least part via (an indirect effect). Here, we show estimates can be obtained using...

10.1534/genetics.117.300191 article EN Genetics 2017-08-22
Siddhartha Kar Jonathan Beesley Ali Amin Al Olama Kyriaki Michailidou Jonathan P. Tyrer and 95 more Zsofia Kote‐Jarai Kate Lawrenson Sara Lindström Susan J. Ramus Deborah J. Thompson Adam S. Kibel Agnieszka Dansonka‐Mieszkowska Agnieszka Michael Aida Karina Dieffenbach Aleksandra Gentry‐Maharaj Alice S. Whittemore Alicja Wolk Álvaro N.A. Monteiro Ana Peixoto Andrzej Kierzek Angela Cox Anja Rudolph Anna González‐Neira Anna H. Wu Annika Lindblom Anthony J. Swerdlow Argyrios Ziogas Arif B. Ekici Barbara Burwinkel Beth Y. Karlan Børge G. Nordestgaard Carl Blomqvist Catherine Phelan Catriona McLean Celeste Leigh Pearce Celine M. Vachon Cezary Cybulski Chavdar Slavov Christa Stegmaier Christiane Maier Christine B. Ambrosone Claus Høgdall Craig C. Teerlink Daehee Kang Daniel C. Tessier Daniel J. Schaid Daniel O. Stram Daniel W. Cramer David E. Neal Diana Eccles Dieter Flesch‐Janys Digna R. Velez Edwards Dominika Wokozorczyk Douglas A. Levine Drakoulis Yannoukakos Elinor J. Sawyer Elisa V. Bandera Elizabeth M. Poole Ellen L. Goode Э. К. Хуснутдинова Estrid Høgdall Fengju Song Fiona Bruinsma Florian Heitz Francesmary Modugno Freddie C. Hamdy Fredrik Wiklund Graham G. Giles Håkan Olsson Hans Wildiers Hans-Ulrich Ulmer Hardev Pandha Harvey A. Risch Hatef Darabi Helga B. Salvesen Heli Nevanlinna Henrik Grönberg Hermann Brenner Hiltrud Brauch Hoda Anton‐Culver Honglin Song Hui-Yi Lim Iain A. McNeish Ian Campbell Ignace Vergote Jacek Gronwald Jan Lubiński Janet L. Stanford Javier Benı́tez Jennifer A. Doherty Jennifer B. Permuth Jenny Chang‐Claude Jenny Donovan Joe Dennis Joellen M. Schildkraut Johanna Schleutker John L. Hopper Jolanta Kupryjańczyk Jong Y. Park Jonine D. Figueroa

Abstract Breast, ovarian, and prostate cancers are hormone-related may have a shared genetic basis, but this has not been investigated systematically by genome-wide association (GWA) studies. Meta-analyses combining the largest GWA meta-analysis data sets for these totaling 112,349 cases 116,421 controls of European ancestry, all together in pairs, identified at P < 10−8 seven new cross-cancer loci: three associated with susceptibility to (rs17041869/2q13/BCL2L11;...

10.1158/2159-8290.cd-15-1227 article EN Cancer Discovery 2016-07-19

Abstract We present and assess the UK Biobank (UKB) Polygenic Risk Score (PRS) Release, a set of PRSs for 28 diseases 25 quantitative traits being made available on individuals in UKB. also release benchmarking software tool to enable like-for-like performance evaluation different same disease or trait. Extensive shows UKB Release outperform broad 81 published PRSs. For many we validate PRS algorithms other cohorts. The availability 53 allows systematic assessment their properties, increased...

10.1101/2022.06.16.22276246 preprint EN cc-by medRxiv (Cold Spring Harbor Laboratory) 2022-06-16

We assess the UK Biobank (UKB) Polygenic Risk Score (PRS) Release, a set of PRSs for 28 diseases and 25 quantitative traits that has been made available on individuals in UKB, using unified pipeline PRS evaluation. also release benchmarking software tool to enable like-for-like performance evaluation different same disease or trait. Extensive shows UKB Release outperform broad 76 published PRSs. For many we validate algorithms separate cohort (100,000 Genomes Project). The availability 53...

10.1371/journal.pone.0307270 article EN cc-by PLoS ONE 2024-09-18

Neurofibromatosis type 1 (NF1) is an autosomal dominant condition affecting around one in 3000 live births. The manifestations of this are extremely variable, even within families, and genetic counselling consequently difficult with regard to prognosis. Individuals NF1 acknowledged be at increased risk malignancy. Several studies have previously attempted quantify risk, but involved relatively small study populations. We present prospective data from 448 individuals a total 5705 years...

10.1038/sj.bjc.6603227 article EN cc-by-nc-sa British Journal of Cancer 2006-06-20
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