A5082372753- BRCA gene mutations in cancer
- Global Cancer Incidence and Screening
- Advanced Breast Cancer Therapies
- Cancer Risks and Factors
- Chronic Lymphocytic Leukemia Research
- Breast Cancer Treatment Studies
- HER2/EGFR in Cancer Research
- Birth, Development, and Health
- Nutritional Studies and Diet
- Genetic Associations and Epidemiology
- Nutrition and Health in Aging
- Estrogen and related hormone effects
- Digital Radiography and Breast Imaging
- AI in cancer detection
- SARS-CoV-2 and COVID-19 Research
- Cancer, Lipids, and Metabolism
- COVID-19 and Mental Health
- Gut microbiota and health
- COVID-19 Clinical Research Studies
- COVID-19 epidemiological studies
- Body Composition Measurement Techniques
- Nutrition, Genetics, and Disease
- Protein Degradation and Inhibitors
- Cancer-related Molecular Pathways
- Influenza Virus Research Studies
Karolinska Institutet
2016-2025
China Tobacco
2023-2025
Renji Hospital
2021-2025
Shanghai Jiao Tong University
2021-2025
Hangzhou Red Cross Hospital
2025
Tianjin University
2025
Tianjin Medical University
2025
Meizhou City People's Hospital
2025
Chinese Academy of Agricultural Sciences
2024
Children's Hospital of Zhejiang University
2021-2024
Genetic testing for breast cancer susceptibility is widely used, but many genes, evidence of an association with weak, underlying risk estimates are imprecise, and reliable subtype-specific lacking.
To investigate ethnic difference in the associations of BMI with comorbidity, mortality, and body composition between mainland Chinese U.S. whites.Ethnic-comparison study using data from China Health Nutrition Survey, National Examination Zhejiang University (China) Columbia (U.S.).Chinese people experienced greater odds comorbidities than whites for a given after standardizing age sex: 43% diabetes, 30% dyslipidemia, 28% hypertension, 38% metabolic syndrome, 48% hyperuricemia. Comparisons...
Rationale: Evidence linking saturated fat intake with cardiovascular health is controversial. The associations of unsaturated fats total and disease (CVD) mortality remain inconsistent, data about non-CVD are limited. Objective: To assess dietary in relation to cause-specific mortality. Methods Results: We analyzed 521 120 participants aged 50 71 years from the National Institutes Health-American Association Retired Persons Diet Health Study 16 follow-up. Intakes fatty acids (SFAs),...
Abstract Tumor antigens and innate signals are vital considerations in developing new therapeutic or prophylactic antitumor vaccines. The role requirement of intact tumor cells the development an effective vaccine remains incompletely understood. This study reveals mechanism by which cell–derived microparticles (T-MP) can act as a cell-free vaccine. Vaccinations with T-MPs give rise to effects against challenge various cell types, while T-MP–loaded dendritic (DC) also exhibit models. Such...
Abstract Genome-wide association studies (GWAS) have identified more than 170 breast cancer susceptibility loci. Here we hypothesize that some risk-associated variants might act in non-breast tissues, specifically adipose tissue and immune cells from blood spleen. Using expression quantitative trait loci (eQTL) reported these identify 26 previously unreported, likely target genes of overall risk variants, 17 for estrogen receptor (ER)-negative cancer, several with a known function. We...
Background China implemented a partial two-child policy (2013) followed by universal (2015), replacing the former one-child mandated government. The changes affect many aspects of China's population as well maternal and infant health, but their potential impact on birth defects (BDs) remains unknown. In this study, we investigated associations these with BDs in Zhejiang Province, China. Methods findings We used data from BD surveillance system China, which covers 90 hospitals 30 urban...
Projecting the burden of pancreatic cancer over time provides essential information to effectively plan measures for its management and prevention. Here, we obtained data from Global Burden Disease (GBD) Study between 1990 2019, model how will affect 27 countries European Union (EU) plus United Kingdom (the pre-Brexit EU-28) until 2039 by conducting Bayesian age-period-cohort analysis. The number new cases in EU-28 was 59 000 1990, 109 2019 projected be 147 2039. This corresponded 60 000,...
Abstract Background In addition to the established association between general obesity and breast cancer risk, central circulating fasting insulin glucose have been linked development of this common malignancy. Findings from previous studies, however, inconsistent, nature associations is unclear. Methods We conducted Mendelian randomization analyses evaluate using genetic instruments, with insulin, glucose, 2-h body mass index (BMI) BMI-adjusted waist-hip-ratio (WHRadj BMI). first confirmed...
To identify predictors of discontinuation adjuvant hormone therapy in patients with breast cancer.We conducted a record-linkage study based on data from Stockholm-Gotland Breast Cancer Register, Swedish Prescribed Drug and self-reported questionnaire. Women diagnosed cancer between 2005 2008 Stockholm, Sweden, were prospectively followed for 5 years until 2013, starting their first prescription tamoxifen or aromatase inhibitors (N = 3,395).Family history ovarian (hazard ratio [HR], 1.55; 95%...
The potential beneficial effect of individual antioxidants on mortality has been reported. However, the association overall intakes dietary with all-cause and cause-specific among adults diabetes remained unclear.A total 4,699 US were enrolled in 2003-2014 National Health Nutrition Examination Survey (NHANES) followed for until 31 December 2015. Dietary Antioxidant Quality Score (DAQS) Index (DAI), which indicate antioxidant properties, calculated based vitamins A, C, E, zinc, selenium,...
Abstract The association between sarcopenia and OA still presents many uncertainties. We aimed to assess whether is associated with occurrence of in US adults. conducted a cross-sectional study consisting 11,456 participants from National Health Nutrition Examination Survey 1999–2006. Sarcopenia was defined by low muscle mass. skeletal index (SMI) calculated as the appendicular mass divided body indexes (BMI) or weight. status assessed using self-reported questionnaire. evaluated...
Abstract Background Prevailing dietary guidelines recommend regular fish consumption. However, the associations of and long‐chain omega‐3 polyunsaturated fatty acids ( LC n‐3 PUFA s) intakes with mortality remain unclear. Objectives To examine s total cause‐specific mortality. Methods A 240 729 men 180 580 women from NIH ‐ AARP Diet Health Study were prospectively followed‐up for 16 years. Dietary assessed using a validated History Questionnaire. Results 54 230 30 882 died during 6.07...
Abstract Objectives To explore assessment of supra‐annular structure for self‐expanding transcatheter heart valve (THV) size selection in patients with bicuspid aortic stenosis (AS). Background Annulus‐based device from CT measurement is the standard sizing strategy tricuspid before replacement (TAVR). Because deformity, AS has not been systemically studied. Methods Twelve who underwent TAVR THVs were included this study. assess structure, sequential balloon valvuloplasty was performed every...
Abstract Background Increasing evidence highlights healthy dietary patterns and links daily cooking oil intake with chronic diseases including cardiovascular disease (CVD) diabetes. However, food-based supporting the consumption of oils in relation to total cardiometabolic mortality remains largely absent. We aim prospectively evaluate relations death from (CVD diabetes) other causes. Methods identified followed 521,120 participants aged 50–71 years National Institutes Health-American...
Abstract Background Osteoarthritis is a degenerative joint disease. Cartilage degeneration the earliest and most important pathological change in osteoarthritis, persistent inflammation one of driving factors cartilage degeneration. Cucurbitacin E, an isolated compound family, has been shown to have anti-inflammatory effects, but its role mechanism osteoarthritic chondrocytes are unclear. Methods For vitro experiments, human were stimulated with IL-1β, expression inflammatory genes was...
Starch is an essential factor affecting the quality of flue-cured tobacco, and high starch content can affect sensory safety. Recently, degradation macromolecules in tobacco raw materials by using additional microorganisms to improve their intrinsic safety has become a new research hotspot industry. However, technical maturity application scale are limited. Our study analyzed correlation between microbial community composition volatile components on surface leaves from 14 different grades...

 We examine the performance and market timing ability of actively managed Chinese stock mutual funds investigate how fund characteristics flows relate to ability. Based on daily return data several four-factor models, only about 7.5% these have statistically significant risk-adjusted abnormal returns even fewer demonstrate After controlling for size, management fees, average amount, volatility flows, older show higher Sharpe ratios. Our evidence also reveals has an inverted-U shape...
Abstract Catalpol, a natural product mainly existed in plenty of Chinese traditional medicines, is an iridoid compound with the comprehensive effects on neuroprotective, anti-inflammatory, choleretic, hypoglycemic and anticancer. However, there are some disadvantages for catalpol such as short half-life vivo, low druggability, stingy binding efficiency to target proteins so on. It necessary make structural modification optimization which enhance its performance disease treatments clinic...
Germline or somatic loss-of-function mutations of fumarate hydratase (FH) predispose patients to an aggressive form renal cell carcinoma (RCC). Since other than tumor resection, there is no effective therapy for metastatic FH-deficient RCC, accurate method early diagnosis needed. Although MRI CT scans are offered, they cannot differentiate tumors from RCCs. Therefore, finding noninvasive plasma biomarkers suitable rapid diagnosis, screening and surveillance would improve clinical outcomes....