Daniele Campa
A5070690527- Pancreatic and Hepatic Oncology Research
- Epigenetics and DNA Methylation
- Genetic Associations and Epidemiology
- Cancer Genomics and Diagnostics
- BRCA gene mutations in cancer
- Multiple Myeloma Research and Treatments
- Telomeres, Telomerase, and Senescence
- Neuroendocrine Tumor Research Advances
- Nutrition, Genetics, and Disease
- Biochemical Analysis and Sensing Techniques
- Drug Transport and Resistance Mechanisms
- Genetic factors in colorectal cancer
- RNA modifications and cancer
- Prostate Cancer Treatment and Research
- Pancreatitis Pathology and Treatment
- Cancer, Lipids, and Metabolism
- Cancer Risks and Factors
- Protein Degradation and Inhibitors
- Cancer-related molecular mechanisms research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- RNA and protein synthesis mechanisms
- Estrogen and related hormone effects
- Nutritional Studies and Diet
- Genomic variations and chromosomal abnormalities
- Genetic Syndromes and Imprinting
University of Pisa
2016-2025
German Cancer Research Center
2014-2023
Heidelberg University
2013-2023
Czech Academy of Sciences, Institute of Experimental Medicine
2021
Charles University
2021
Casa Sollievo della Sofferenza
2020
Istituti di Ricovero e Cura a Carattere Scientifico
2020
DKFZ-ZMBH Alliance
2014-2020
National Institutes of Health
2015
Medical University of Lodz
2014
Stratification of women according to their risk breast cancer based on polygenic scores (PRSs) could improve screening and prevention strategies. Our aim was develop PRSs, optimized for prediction estrogen receptor (ER)-specific disease, from the largest available genome-wide association dataset empirically validate PRSs in prospective studies. The development comprised 94,075 case subjects 75,017 control European ancestry 69 studies, divided into training validation sets. Samples were...
Lung cancer is a leading cause of mortality with an inter-individual difference in susceptibility to the disease. The inheritance low-efficiency genotypes involved DNA repair and replication may contribute susceptibility. We investigated 44 single nucleotide polymorphisms (SNPs) 20 genes including excision (NER) XPA , ERCC1 ERCC2/XPD ERCC4/XPF ERCC5/XPG; base (BER) APE1 / APEX OGG1 MPG XRCC1 PCNA POLB POLι LIG3 EXO1; double-strand break (DSB-R) XRCC2 XRCC3 XRCC9 NBS1 ATR; direct damage...
The pharmacokinetics and pharmacodynamics of morphine are under the control several polymorphic genes, which can account for part observed interindividual variation in pain relief. We focused on two such genes: ABCB1/MDR1, a major determinant bioavailability, OPRM1, encodes μ-opioid receptor, primary site action morphine. One hundred forty-five patients Italian origin undergoing therapy were genotyped single-nucleotide polymorphism (SNP) C3435T ABCB1/MDR1 A80G SNP OPRM1. Pain relief...
Studies have indicated that inflammation, in conjunction with the production of reactive oxygen species, may play a key role lung cancer development. In this study, 250 patients and 214 controls were genotyped for polymorphisms inflammation-related genes prostaglandin synthase-2/cyclooxygenase-2 ( COX2 / PTGS2 ), interleukin-6 IL6 interleukin-8 IL8 ) peroxisome proliferator-activated receptor γ PPAR g). We found carriers C allele polymorphism 3′-UTR had significantly increased risk cancer,...
Recently, several genome-wide association studies have identified various genetic susceptibility loci for breast cancer. Relatively little is known about the possible interactions between these and established risk factors cancer.To assess single-nucleotide polymorphisms (SNPs) factors, we prospectively collected DNA samples questionnaire data from 8576 cancer case subjects 11 892 control nested within National Cancer Institute's Breast Prostate Cohort Consortium (BPC3). We genotyped 17...
Genome-wide association studies (GWAS) have identified multiple single nucleotide polymorphisms (SNPs) associated with prostate cancer risk. However, whether these associations can be consistently replicated, vary disease aggressiveness (tumor stage and grade) and/or interact non-genetic potential risk factors or other SNPs is unknown. We therefore genotyped 39 from regions by several GWAS in 10,501 cases 10,831 controls the NCI Breast Prostate Cancer Cohort Consortium (BPC3). replicated 36...
Molecular sensing in the lingual mucosa and gastro-intestinal tract play a role detection of ingested harmful drugs toxins. Therefore, genetic polymorphisms affecting capability initiating these responses may be critical for subsequent efficiency avoiding and/or eliminating possible threats to organism. By using tagging approach region Taste Receptor 2R38 (TAS2R38) gene, we investigated all common variation this gene relation colorectal cancer risk with case-control study German population...
Abstract Genome-wide association studies (GWAS) have identified more than 170 breast cancer susceptibility loci. Here we hypothesize that some risk-associated variants might act in non-breast tissues, specifically adipose tissue and immune cells from blood spleen. Using expression quantitative trait loci (eQTL) reported these identify 26 previously unreported, likely target genes of overall risk variants, 17 for estrogen receptor (ER)-negative cancer, several with a known function. We...
Abstract Quantifying the genetic correlation between cancers can provide important insights into mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six types based on a total of 296,215 cases and 301,319 controls European ancestry, here we estimate pair-wise correlations breast, colorectal, head/neck, lung, ovary prostate cancer, 38 other diseases. We observed statistically significant lung head/neck ( r g = 0.57, p 4.6 × 10 −8 ), breast ovarian...
Associations between single nucleotide polymorphisms (SNPs) at 5p15 and multiple cancer types have been reported. We previously shown evidence for a strong association prostate (PrCa) risk rs2242652 5p15, intronic in the telomerase reverse transcriptase (TERT) gene that encodes TERT. To comprehensively evaluate genetic variation across this region PrCa, we performed fine-mapping analysis by genotyping 134 SNPs using custom Illumina iSelect array or Sequenom MassArray iPlex, followed...
// Mingfeng Zhang 1 , Zhaoming Wang 2,3,100 Ofure Obazee 4 Jinping Jia Erica J. Childs 5 Jason Hoskins Gisella Figlioli Evelina Mocci Irene Collins Charles C. Chung 2,3 Christopher Hautman Alan A. Arslan 6,7,8 Laura Beane-Freeman 2 Paige M. Bracci 9 Julie Buring 10,11 Eric Duell 12 Steven Gallinger 13 Graham G. Giles 14,15,16 Gary E. Goodman 17 Phyllis 18 Aruna Kamineni 19 Laurence N. Kolonel 20 Matthew H. Kulke 21 Núria Malats 22 Sara Olson 23 Howard D. Sesso 24,10,11 Kala...
Most men diagnosed with prostate cancer will experience indolent disease; hence, discovering genetic variants that distinguish aggressive from nonaggressive is of critical clinical importance for disease prevention and treatment. In a multistage, case-only genome-wide association study 12,518 cases, we identify two loci associated Gleason score, pathological measure aggressiveness: rs35148638 at 5q14.3 (RASA1, P=6.49 × 10−9) rs78943174 3q26.31 (NAALADL2, P=4.18 10−8). stratified case–control...
Abstract The ability to taste phenylthiocarbamide (PTC) and 6-n-propylthiouracil (PROP) is a polymorphic trait mediated by the TAS2R38 bitter receptor gene. It has long been hypothesized that global genetic diversity at this locus evolved under pervasive pressures from balancing natural selection. However, recent high-resolution population studies of TAS2Rs suggest demographic events have played critical role in evolution these genes. We here utilized largest database yet analyzed,...
Physical inactivity and sedentary behaviour are associated with higher breast cancer risk in observational studies, but ascribing causality is difficult. Mendelian randomisation (MR) assesses by simulating randomised trial groups using genotype. We assessed whether lifelong physical activity or time, genotype, may be causally overall, pre/post-menopause, case-groups defined tumour characteristics.
Early-onset pancreatic cancer (EOPC) represents 5-10% of all ductal adenocarcinoma (PDAC) cases, and the etiology this form is poorly understood. It not clear if established PDAC risk factors have same relevance for younger patients. This study aims to identify genetic non-genetic specific EOPC.A genome-wide association was performed, analysing 912 EOPC cases 10 222 controls, divided into discovery replication phases. Furthermore, associations between a polygenic score (PRS), smoking,...