A5058627314- Pancreatic and Hepatic Oncology Research
- Pancreatitis Pathology and Treatment
- Neuroendocrine Tumor Research Advances
- Cancer Genomics and Diagnostics
- Gallbladder and Bile Duct Disorders
- Renal cell carcinoma treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Epigenetics and DNA Methylation
- Gastric Cancer Management and Outcomes
- CAR-T cell therapy research
- Cancer Immunotherapy and Biomarkers
- Gastrointestinal disorders and treatments
- Cell Adhesion Molecules Research
- Cancer Cells and Metastasis
- Pediatric Hepatobiliary Diseases and Treatments
- Lung Cancer Research Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Esophageal and GI Pathology
- RNA modifications and cancer
- Cancer Research and Treatments
- MicroRNA in disease regulation
- Pancreatic function and diabetes
- Neuroblastoma Research and Treatments
- Radiomics and Machine Learning in Medical Imaging
- Single-cell and spatial transcriptomics
University Hospital Heidelberg
2016-2025
Heidelberg University
2016-2025
Medical University of Vienna
2001-2025
Yahoo (United Kingdom)
2024
Flinders Medical Centre
2024
Flinders University
2024
Dutch Institute for Clinical Auditing
2024
Cambridge University Hospitals NHS Foundation Trust
2023
University of Vienna
2022
Vienna General Hospital
2021-2022
Objective: For patients with locally advanced and unresectable pancreatic cancer (PDAC), neodadjuvant treatment consecutive surgical exploration have been studied during the last decade various neoadjuvant therapies including chemotherapy combinations radiation. Aim of study was evaluation therapy a focus on Folfirinox. Methods: All undergoing surgery for PDAC after were analyzed (clinico-pathological characteristics, secondary resection rates, outcome). Patients receiving Folfirinox...
Surgery is the only therapy with potentially curative intention in pancreatic cancer. This analysis aimed to determine prognostic parameters a patient cohort resected adenocarcinoma special focus on revised R1-definition.Between October 2001 and August 2009, data from 1071 consecutively patients were prospectively collected an electronical database. Parameters tested for survival prediction univariate included patient, tumor, resection characteristics as well adjuvant therapy. The...
To assess the relevance of resection margin status for survival outcome after and adjuvant therapy pancreatic cancer.The definitions R0 R1 cancer are controversial. The strict definition requiring a 1 mm tumor-free is not commonly accepted. Reported R0/R1 rates associated highly heterogeneous.A standardized protocol with rigorous assessment circumferential margins free were introduced into clinical routine in 2005. From prospective database, patients undergoing pancreatoduodenectomy...
Local and distant disease recurrence are frequently observed following pancreatic cancer resection, but an improved understanding of resection margin assessment is required to aid tailored therapies.
To determine the prognostic value of PLN and LNR based on a large series with standardized lymphadenectomy pathological workup.Lymph node (LN) involvement is major factor in pancreatic adenocarcinoma. However, distinction N0/N1 not sufficient to accurately predict prognosis. improve accuracy N1 tumors, different LN parameters have been tested. Previous studies were variable numbers examined lymph nodes (ELN) came inconsistent conclusions as number positive (PLN) ratio (LNR).811 patients who...
The patterns of disease recurrence after resection pancreatic ductal adenocarcinoma with adjuvant chemotherapy remain unclear.
Abstract We used whole-genome and transcriptome sequencing to identify clinically actionable genomic alterations in young adults with pancreatic ductal adenocarcinoma (PDAC). Molecular characterization of 17 patients PDAC enrolled a precision oncology program revealed gene fusions amenable pharmacologic inhibition by small-molecule tyrosine kinase inhibitors all KRAS wild-type (KRASWT) tumors (4 17). These included recurrent NRG1 rearrangements predicted drive development through aberrant...
This dual-center, randomized, controlled, noninferiority trial aimed to prove that omission of drains does not increase reintervention rates after pancreatic surgery.There is considerable uncertainty regarding intra-abdominal drainage pancreatoduodenectomy.Patients undergoing head resection with pancreaticojejunal anastomosis were randomized versus no drainage. Primary endpoint was overall rate (relaparotomy or radiologic intervention). Secondary endpoints clinically relevant fistula (grade...
Objective: The ISGPS aimed to develop a universally accepted definition for PPAP standardized reporting and outcome comparison. Background: : is an increasingly recognized complication after partial pancreatic resections, but its incidence clinical impact, even existence are variable because internationally consensus grading system lacking. Methods: developed of with members evidence review series discussions multiple revisions from April 2020 May 2021. Results: We defined as acute...
Radiotherapy is a mainstay cancer therapy whose antitumor effects partially depend on T cell responses. However, the role of Natural Killer (NK) cells in radiotherapy remains unclear. Here, using reverse translational approach, we show central NK radiation-induced immune response involving CXCL8/IL-8–dependent mechanism. In randomized controlled pancreatic trial, CXCL8 increased under radiotherapy, and positively correlated with prolonged overall survival. Accordingly, preferentially...
Cancer-associated fibroblasts (CAFs) are considered to play a fundamental role in pancreatic ductal adenocarcinoma (PDAC) progression and chemoresistance. Patient-derived organoids have demonstrated great potential as tumor avatars for drug response prediction PDAC, yet they disregard the influence of stromal components on chemosensitivity.We established direct three-dimensional (3D) co-cultures primary PDAC patient-matched CAFs investigate effect fibroblastic compartment sensitivity...
Aims: The introduction of clearly defined histopathological criteria for a standardised evaluation the periprosthetic membrane, which can appear in cases total joint arthroplasty revision surgery. Methods: Based on histomorphological criteria, four types membrane were defined: wear particle induced type (detection foreign body particles; macrophages and multinucleated giant cells occupy at least 20% area; I); infectious (granulation tissue with neutrophilic granulocytes, plasma few, if any,...
In Brief Objective: The aim of this study was to evaluate existing management guidelines for branch-duct intraductal papillary mucinous neoplasms (IPMNs). Background: According current treatment (Sendai criteria), patients with asymptomatic type IPMNs the pancreas less than 3 cm in diameter without suspicious features preoperative imaging should undergo conservative yearly follow-up examinations. Nevertheless, risk harboring malignancy or invasive cancer remains a significant matter...
To evaluate the safety and outcome of multivisceral pancreatic resections for primary malignancies.Curative resection is only potential cure patients with cancer, but some present advanced tumors that are not resectable by a standard resection. Data on risk survival analysis extended limited.One hundred one who had between 10/2001 12/2007 were identified from prospective database, perioperative long-term results compared those 202 matched Uni- multivariate regression performed to identify...