Objective: For patients with locally advanced and unresectable pancreatic cancer (PDAC), neodadjuvant treatment consecutive surgical exploration have been studied during the last decade various neoadjuvant therapies including chemotherapy combinations radiation. Aim of study was evaluation therapy a focus on Folfirinox. Methods: All undergoing surgery for PDAC after were analyzed (clinico-pathological characteristics, secondary resection rates, outcome). Patients receiving Folfirinox...

The objective of this study was to identify potential risk factors for mortality and morbidity after distal pancreatectomy, with special focus on the formation pancreatic fistula.Distal pancreatectomy can be performed low acceptable rates. Pancreatic fistulas, occurring in 10% 20% cases, remain a problem that contributes significantly morbidity, length stay, overall costs.From November 1993 February 2006, perioperative postoperative data 302 consecutive patients were recorded. Univariate...

Surgery is the only therapy with potentially curative intention in pancreatic cancer. This analysis aimed to determine prognostic parameters a patient cohort resected adenocarcinoma special focus on revised R1-definition.Between October 2001 and August 2009, data from 1071 consecutively patients were prospectively collected an electronical database. Parameters tested for survival prediction univariate included patient, tumor, resection characteristics as well adjuvant therapy. The...

To assess the relevance of resection margin status for survival outcome after and adjuvant therapy pancreatic cancer.The definitions R0 R1 cancer are controversial. The strict definition requiring a 1 mm tumor-free is not commonly accepted. Reported R0/R1 rates associated highly heterogeneous.A standardized protocol with rigorous assessment circumferential margins free were introduced into clinical routine in 2005. From prospective database, patients undergoing pancreatoduodenectomy...

To determine the prognostic value of PLN and LNR based on a large series with standardized lymphadenectomy pathological workup.Lymph node (LN) involvement is major factor in pancreatic adenocarcinoma. However, distinction N0/N1 not sufficient to accurately predict prognosis. improve accuracy N1 tumors, different LN parameters have been tested. Previous studies were variable numbers examined lymph nodes (ELN) came inconsistent conclusions as number positive (PLN) ratio (LNR).811 patients who...

Objective To review a single-center experience with 201 multivisceral resections for primary colorectal cancer to determine the accuracy of intraoperative prediction potential curability, identify prognostic factors, and examine effect surgical on immediate outcome long-term results. Summary Background Data Locally advanced may require an decision en bloc resection surrounding organs or structures achieve complete tumor removal. This must weigh risk complications death against survival...

In Brief Objective: To evaluate the perioperative and long-term results of total pancreatectomy (TP), to assess whether it provides morbidity, mortality, quality life (QoL) comparable those pylorus-preserving (pp)-Whipple procedure in patients with benign malignant pancreatic disease. Summary Background Data: TP was abandoned for decades because high peri- postoperative morbidity mortality. Because selected diseases are best treated by TP, surgery management exocrine endocrine insufficiency...

Abstract Background The aim was to assess the clinical relevance of World Health Organization and tumour node metastasis (TNM) classifications in patients with pancreatic neuroendocrine tumours (pNETs). Methods Prospectively collected data from 118 consecutive a pNET receiving surgical intervention were analysed. Results Forty-one had well differentiated tumours, 64 carcinomas 13 poorly carcinomas. Five-year survival rates 95, 44 0 per cent respectively (P < 0·001). There no...

This study evaluates the outcome of patients who underwent surgery for recurrent pancreatic cancer.Recurrence ductal adenocarcinoma occurs in up to 80% cancer within 2 years a potential curative resection because, most cases, occult (local and/or distant) micrometastases are present at time initial resection.Thirty were operated between October 2001 and April 2005. Median recurrence was 12.0 months. While 15 resected, either palliative bypass or only exploration. Prospectively recorded data...

Objective This study compares the results of liver transplantation (LTx) and resection (LR) for hepatocellular carcinoma (HCC) to test widespread hypothesis that LTx is preferable approach small HCCs. Summary Background Data With respect scarcity donor organs poor results, LTxs large HCCs are obsolete. Small HCC transplantations have been reported result in an excellent survival rate. However, data comparative studies controversial. Methods Patients who were treated curatively by (n = 50) or...

Objective To analyze the association between pre- and perioperative factors pouch-related septic complications (PRSC) in ulcerative colitis (UC) familial adenomatous polyposis (FAP) after ileal pouch–anal anastomosis (IPAA). Summary Background Data For patients with UC FAP, IPAA is surgical therapy of choice, but some outcome compromised by PRSC. Methods A total 706 consecutive (494 UC, 212 FAP) were assessed a study aimed at identifying subgroups who high risk for The rate PRSC was analyzed...

To evaluate the safety and outcome of multivisceral pancreatic resections for primary malignancies.Curative resection is only potential cure patients with cancer, but some present advanced tumors that are not resectable by a standard resection. Data on risk survival analysis extended limited.One hundred one who had between 10/2001 12/2007 were identified from prospective database, perioperative long-term results compared those 202 matched Uni- multivariate regression performed to identify...

Abstract Purpose: Cell surface HLA class I molecules present peptides derived from human cellular proteins to T cells. In the study, we investigated expression of in pancreatic carcinoma. Experimental Design: The antigen and extent tumor infiltration by cells were 46 primary tumors 14 metastases cancer standard immunohistochemistry. Results: locus-specific was reduced 61% 93% metastases. total loss this molecule complex detected 6% 43% Pancreatic carcinoma peritumoral tissue showed a...

Abstract Background Intraductal papillary mucinous neoplasm (IPMN) of the pancreas has malignant potential. Although serum levels carbohydrate antigen (CA) 19-9 and carcinoembryonic (CEA) are known to be raised in pancreatic ductal adenocarcinoma, little been reported about their significance IPMN. Methods Preoperative CA19-9 CEA were measured consecutive patients undergoing surgical resection for Results correlated with histopathological clinical features. In 142 patients, significantly...

Abstract Background In the recent International Study Group of Pancreatic Surgery (ISGPS) consensus on extended pancreatectomy, several issues perioperative outcome and long-term survival remained unclear. Robust data outcomes are sparse. The present study aimed to assess pancreatectomy for borderline resectable locally advanced pancreatic cancer. Methods A consecutive series patients with primary adenocarcinoma undergoing pancreatectomies, as defined by new ISGPS consensus, were compared...

Abstract Background Delayed gastric emptying (DGE) is a common complication after pancreatoduodenectomy. The International Study Group of Pancreatic Surgery (ISGPS) definition DGE has not been evaluated and validated in high-volume centre. Methods Complete data sets including assessment were identified from database patients undergoing pancreatoduodenectomy between 2001 2008. Factors associated with (grades A, B C) assessed by univariable multivariable analyses. Results occurred 340 (44·5...