A5070409313- Pancreatic and Hepatic Oncology Research
- Pancreatitis Pathology and Treatment
- Neuroendocrine Tumor Research Advances
- Chemokine receptors and signaling
- Cardiac, Anesthesia and Surgical Outcomes
- Immunotherapy and Immune Responses
- Gallbladder and Bile Duct Disorders
- Gastric Cancer Management and Outcomes
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Esophageal and GI Pathology
- Organ Transplantation Techniques and Outcomes
- Renal cell carcinoma treatment
- Clinical practice guidelines implementation
- Intestinal and Peritoneal Adhesions
- Intraperitoneal and Appendiceal Malignancies
- Liver Disease and Transplantation
- Gastrointestinal Tumor Research and Treatment
- Appendicitis Diagnosis and Management
- Meta-analysis and systematic reviews
- Colorectal Cancer Screening and Detection
- Hernia repair and management
- Medical Practices and Rehabilitation
- Colorectal Cancer Surgical Treatments
- Enhanced Recovery After Surgery
- Gastroesophageal reflux and treatments
Heidelberg University
2005-2015
B. Braun (Germany)
2015
Aesculap (United States)
2012
University Hospital Heidelberg
2003-2011
German Society of Surgery
2005-2011
Chirurgische Universitätsklinik Heidelberg
2003-2011
Heidelberg University
2006-2011
University of California, Los Angeles
2001-2006
General Department of Preventive Medicine
2004
University Hospital of Bern
2000
Adjuvant fluorouracil has been shown to be of benefit for patients with resected pancreatic cancer. Gemcitabine is known the most effective agent in advanced disease as well an cancer.To determine whether or gemcitabine superior terms overall survival adjuvant treatment following resection cancer.The European Study Group Pancreatic Cancer (ESPAC)-3 trial, open-label, phase 3, randomized controlled trial conducted 159 cancer centers Europe, Australasia, Japan, and Canada. Included ESPAC-3...
Objective: Lethal sepsis occurs when an excessive inflammatory response evolves that cannot be controlled by physiologic anti-inflammatory mechanisms, such as the recently described cholinergic pathway. Here we studied whether pathway can activated pharmacologic cholinesterase inhibition in vivo. Design: Prospective, randomized laboratory investigation used established murine model. Setting: Research a university hospital. Subjects: Female C57BL/6 mice. Interventions: Sepsis mice was induced...
Abstract Background Delayed gastric emptying (DGE) is a common complication after pancreatoduodenectomy. The International Study Group of Pancreatic Surgery (ISGPS) definition DGE has not been evaluated and validated in high-volume centre. Methods Complete data sets including assessment were identified from database patients undergoing pancreatoduodenectomy between 2001 2008. Factors associated with (grades A, B C) assessed by univariable multivariable analyses. Results occurred 340 (44·5...
To clarify whether middle segmental pancreatic resection can be performed with comparable morbidity and mortality to classic resections for lesions in the mid-portion of pancreas.Pancreaticoduodenectomies or distal pancreatectomy, traditionally used treat body, sacrifice a significant amount normal tissue. Middle has therefore been introduced minimize loss functioning tissue.In prospective 4-year single-center study, 40 consecutive patients neck body pancreas underwent resection. A...
To analyze the role of Artemin in pancreatic ductal adenocarcinoma (PDAC) terms expression, influence on cancer cell behavior, and pain correlation.PDAC is characterized by prominent local nerve alterations perineural invasion, which frequently affects extrapancreatic plexus, causing severe precluding curative resection. Artemin, a neurotrophic protein controlling growth, regeneration, survival neurons was analyzed to highlight neuro-cancer interactions PDAC.Artemin its receptors...
Abstract Pancreatic ductal adenocarcinoma (PDAC) is characterized by an abundant desmoplastic stroma. Interactions between cancer and stromal cells play a critical role in tumour invasion, metastasis chemoresistance. Therefore, we hypothesized that gene expression profile of the components pancreatic carcinoma different from chronic pancreatitis reflects interaction with tumour. We investigated eleven tissues PDAC, nine cell lines origin using Affymetrix U133 GeneChip set. The tissue samples...