Mònica Ferrer‐Roda
A5048212197- Reproductive Biology and Fertility
- Renal and related cancers
- Sperm and Testicular Function
- Animal Genetics and Reproduction
- Nutrition, Genetics, and Disease
- Genetics, Aging, and Longevity in Model Organisms
- DNA Repair Mechanisms
- Ovarian function and disorders
- BRCA gene mutations in cancer
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Prenatal Screening and Diagnostics
Universitat Autònoma de Barcelona
2020-2024
Mammalian oogonia proliferate without completing cytokinesis, forming cysts. Within these, oocytes differentiate and initiate meiosis, promoting double-strand break (DSBs) formation, which are repaired by homologous recombination (HR) causing the pairing synapsis of homologs. Errors in these processes activate checkpoint mechanisms, leading to apoptosis. At end prophase I, contrast with what is observed spermatocytes, accumulate unrepaired DSBs. Simultaneously cyst breakdown, there a massive...
The oocyte competence of prepubertal females is lower compared to that adults, mainly because they originate from small follicles. In adult females, the germinal vesicle (GV) and epidermal growth factor receptor (EGFR) have been associated with competence. This study aimed analyze GV chromatin configuration EGFR expression in goat sheep oocytes obtained (<3 mm) large (≥3 follicles compare them those adults. was classified diffuse condensed as GV1, GVn, GVc for goats NSN, SN, SNE sheep....
Abstract Reproductive longevity is critical for fertility and impacts healthy ageing in women, yet insights into the underlying biological mechanisms treatments to preserve it are limited. Here, we identify 290 genetic determinants of ovarian ageing, assessed using normal variation age at natural menopause (ANM) ∼200,000 women European ancestry. These common alleles influence clinical extremes ANM; top 1% susceptibility have an equivalent risk premature insufficiency those carrying monogenic...
Abstract Goat production is affected by reproductive seasonality. In vitro embryo (IVEP) could overcome this effect. This study aimed to evaluate the impact of season semen collection/freezing on IVEP prepubertal goat oocytes and sperm quality functionality concerning capacitation. Semen from six fertile bucks was collected, pooled cryopreserved in spring autumn used for recovered during breeding season. Oocytes were IVM TCM‐199 with hormones, EGF cysteamine; fertilized cultured BO‐IVF...
Oocytes spontaneously resume meiosis following their liberation from follicles, preventing full competence acquisition. Biphasic IVM (CAPA-IVM) maintains oocytes in meiotic arrest to improve developmental competence, and it specially affects poorly developed oocytes. We assessed the effect of CAPA-IVM on small (<3mm) large (>3mm) follicles prepubertal goats. were cultured for 6h pre-IVM with C-type natriuretic peptide (CNP) estradiol as inhibitors, germinal vesicle (GV) rate chromatin...