Janet E. Olson
A5088395323- BRCA gene mutations in cancer
- Genetic Associations and Epidemiology
- Nutrition, Genetics, and Disease
- Estrogen and related hormone effects
- Cancer Genomics and Diagnostics
- Cancer Risks and Factors
- Genetic factors in colorectal cancer
- Epigenetics and DNA Methylation
- Global Cancer Incidence and Screening
- Genomics and Rare Diseases
- Genomic variations and chromosomal abnormalities
- Ethics in Clinical Research
- Genomics and Chromatin Dynamics
- Breast Cancer Treatment Studies
- Chronic Lymphocytic Leukemia Research
- HER2/EGFR in Cancer Research
- Pharmacogenetics and Drug Metabolism
- Health Systems, Economic Evaluations, Quality of Life
- Digital Radiography and Breast Imaging
- Gene expression and cancer classification
- Bioinformatics and Genomic Networks
- DNA Repair Mechanisms
- Lymphoma Diagnosis and Treatment
- AI in cancer detection
- RNA modifications and cancer
Mayo Clinic in Florida
2016-2025
Mayo Clinic in Arizona
2014-2025
Mayo Clinic
2013-2024
WinnMed
2009-2024
University of Alabama at Birmingham
2024
Department of Medical Sciences
2006-2023
Wake Forest University
2015-2023
National Heart Lung and Blood Institute
2023
National Institutes of Health
2010-2023
Exact Sciences (United States)
2023
Background: Recent clinical guidelines on the health risks of obesity use body mass index (BMI; calculated as weight in kilograms divided by square height meters) and waist circumference, but waist-hip ratio may provide independent information. Methods:To assess joint relative associations BMI, with multiple disease end points, we conducted a prospective cohort study 31 702 Iowa women, aged 55 to 69 years free cancer, heart disease, diabetes, assembled random sampling mail survey 1986.Study...
Previous studies have suggested that breast cancer risk factors are associated with estrogen receptor (ER) and progesterone (PR) expression status of the tumors.
Genetic variations, such as single nucleotide polymorphisms (SNPs) in microRNAs (miRNA) or the miRNA binding sites may affect dependent gene expression regulation, which has been implicated various cancers, including breast cancer, and alter individual susceptibility to cancer. We investigated associations between related SNPs cancer risk. First we evaluated 2,196 a case-control study combining nine genome wide association studies (GWAS). Second, further 42 with suggestive evidence for using...
Population-based estimates of the risk breast cancer associated with germline pathogenic variants in cancer-predisposition genes are critically needed for assessment and management women inherited variants.
Purpose Recent advances in DNA sequencing have led to the development of breast cancer susceptibility gene panels for germline genetic testing patients. We assessed frequency mutations 17 predisposition genes, including BRCA1 and BRCA2, a large cohort patients with triple-negative (TNBC) unselected family history or ovarian determine utility those TNBC. Patients Methods TNBC (N = 1,824) were recruited through 12 studies, was sequenced identify mutations. Results Deleterious identified 14.6%...
Data for multiple common susceptibility alleles breast cancer may be combined to identify women at different levels of risk. Such stratification could guide preventive and screening strategies. However, empirical evidence genetic risk is lacking. We investigated the value using 77 cancer-associated single nucleotide polymorphisms (SNPs) stratification, in a study 33 673 cases 381 control European origin. tested all possible pair-wise multiplicative interactions constructed 77-SNP polygenic...
A three-stage genome-wide association study recently identified single nucleotide polymorphisms (SNPs) in five loci (fibroblast growth receptor 2 (FGFR2), trinucleotide repeat containing 9 (TNRC9), mitogen-activated protein kinase 3 K1 (MAP3K1), 8q24, and lymphocyte-specific 1 (LSP1)) associated with breast cancer risk. We investigated whether the associations between these SNPs risk varied by clinically important tumor characteristics up to 23,039 invasive cases 26,273 controls from 20...
Recent changes have occurred in the presurgical planning for breast cancer, including introduction of preoperative magnetic resonance imaging (MRI). We sought to analyze trends mastectomy rates and relationship MRI surgical year at Mayo Clinic, Rochester, MN.We identified 5,405 patients who underwent surgery between 1997 2006. Patients undergoing were from a prospective database. Trends rate association with type analyzed. Multiple logistic regression was used assess effect on type, while...
Observational epidemiological studies have shown that high body mass index (BMI) is associated with a reduced risk of breast cancer in premenopausal women but an increased postmenopausal women. It unclear whether this association mediated through shared genetic or environmental factors.
Background— Whether knowledge of genetic risk for coronary heart disease (CHD) affects health-related outcomes is unknown. We investigated whether incorporating a score (GRS) in CHD estimates lowers low-density lipoprotein cholesterol (LDL-C) levels. Methods and Results— Participants (n=203, 45–65 years age, at intermediate CHD, not on statins) were randomly assigned to receive their 10-year probability based either conventional (CRS) or CRS + GRS ( GRS). the group stratified as having high...
The rarity of mutations in PALB2, CHEK2 and ATM make it difficult to estimate precisely associated cancer risks. Population-based family studies have provided evidence that at least some these are with breast risk as high those rare BRCA2 mutations. We aimed the relative risks specific variants via a multicentre case-control study.
PURPOSE To estimate the risk of contralateral breast cancer (CBC) among women with germline pathogenic variants (PVs) in ATM, BRCA1, BRCA2, CHEK2, and PALB2. METHODS The study population included 15,104 prospectively followed within CARRIERS treated ipsilateral surgery for invasive cancer. CBC was estimated PV carriers each gene compared without PVs a multivariate proportional hazard regression analysis accounting competing death adjusting patient tumor characteristics. primary analyses...
Abstract BACKGROUND Primary central nervous system lymphoma (PCNSL) is an extranodal form of non‐Hodgkin arising in the craniospinal axis. The incidence PCNSL appears to be increasing. METHODS data from 1973–1997 were obtained nine Surveillance, Epidemiology and End Results (SEER) registries. To limit influence human immunodeficiency virus on rates, never–married males females persons unknown marital status excluded. As a surrogate for new technology, SEER reviewed by dates diagnosis...
Epidemiologic studies frequently obtain exposure information through subjects' self-report (personal interview or mailed questionnaire). The authors used data from a case-control study of infant leukemia, to assess the validity and reliability maternally reported on birth characteristics such as weight, reproductive history, medical procedures. Cases were gathered Children's Cancer Group, United States Canadian cooperative clinical trials group with approximately 100 member affiliate...
Low B-vitamin intake may increase risk of breast cancer through decreased DNA repair capacity. Alcohol increases for cancer, with evidence from prospective studies an interaction between alcohol and folate. We explored dietary folate other B vitamins in a cohort study 34,387 postmenopausal women. To measure diet, we mailed food frequency questionnaire; estimated nutrient intakes categorized them into four levels: <10th, 11th-30th, 31st-50th, >50th percentiles. Through 12 years follow-up,...
Predict (www.predict.nhs.uk) is an online, breast cancer prognostication and treatment benefit tool. The aim of this study was to incorporate the prognostic effect HER2 status in a new version (Predict+), compare its performance with original Adjuvant!.The based on analysis data from 10 179 patients 14 studies Breast Cancer Association Consortium. hazard ratio estimates were incorporated into Predict. validation 1653 early-stage invasive identified British Columbia Outcomes Unit. Predicted...
We tested the hypotheses that CHEK2*1100delC heterozygosity is associated with increased risk of early death, breast cancer-specific and a second cancer in women first cancer.From 22 studies participating Breast Cancer Association Consortium, 25,571 white invasive were genotyped for observed up to 20 years (median, 6.6 years). examined death by estrogen receptor status after prospective studies.CHEK2*1100delC was found 459 patients (1.8%). In receptor-positive cancer, multifactorially...