Lauren R. Teras
A5029577209- BRCA gene mutations in cancer
- Cancer Risks and Factors
- Nutrition, Genetics, and Disease
- Lymphoma Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Genetic Associations and Epidemiology
- Chronic Lymphocytic Leukemia Research
- Nutritional Studies and Diet
- Nutrition and Health in Aging
- Ovarian cancer diagnosis and treatment
- Bioinformatics and Genomic Networks
- Estrogen and related hormone effects
- Genetic factors in colorectal cancer
- RNA modifications and cancer
- Genomics and Rare Diseases
- Global Cancer Incidence and Screening
- Cancer, Lipids, and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Colorectal Cancer Screening and Detection
- Multiple and Secondary Primary Cancers
- DNA Repair Mechanisms
- Genomic variations and chromosomal abnormalities
- Multiple Myeloma Research and Treatments
- Immune Cell Function and Interaction
- Metabolism, Diabetes, and Cancer
American Cancer Society
2016-2025
Czech Academy of Sciences
2023
Czech Academy of Sciences, Institute of Molecular Genetics
2023
National Cancer Centre Singapore
2023
Charles University
2023
General University Hospital in Prague
2023
National Cancer Institute
2015-2022
University of Hawaii System
2016-2022
Centre International de Recherche sur le Cancer
2022
Moffitt Cancer Center
2022
Collectively, lymphoid neoplasms are the fourth most common cancer and sixth leading cause of death in United States. The authors provide contemporary neoplasm statistics by subtype based on 2008 World Health Organization classifications, including current US incidence survival data. Presented for first time estimates total numbers cases as well a detailed evaluation statistics. In 2016, 136,960 new expected. Overall lymphoma rates have declined recent years, but trends vary subtype....
PURPOSE To estimate the risk of contralateral breast cancer (CBC) among women with germline pathogenic variants (PVs) in ATM, BRCA1, BRCA2, CHEK2, and PALB2. METHODS The study population included 15,104 prospectively followed within CARRIERS treated ipsilateral surgery for invasive cancer. CBC was estimated PV carriers each gene compared without PVs a multivariate proportional hazard regression analysis accounting competing death adjusting patient tumor characteristics. primary analyses...
Germline BRCA2 loss-of function variants, which can be identified through clinical genetic testing, predispose to several cancers1–5. However, variants of uncertain significance limit the utility test results. Thus, there is a need for functional characterization and classification all facilitate management individuals with these variants. Here we analysed possible single-nucleotide from exons 15 26 that encode DNA-binding domain hotspot pathogenic missense To enable this, used saturation...
Excess adiposity and hormone replacement therapy (HRT) are important contributors to postmenopausal breast cancer risk. HRT has been shown modify the association between body weight risk, although few studies sufficiently large examine risk of associated with mass index (BMI) gain separately among current users nonusers. This study includes 1,934 incident cases occurring 62,756 women in Cancer Prevention Study-II Nutrition Cohort. Age-adjusted incidence rates were calculated, Cox...
Social isolation is associated with higher mortality in studies comprising mostly white adults, yet associations among black adults are unclear. In this prospective cohort study, we evaluated whether of social all-cause, cardiovascular disease, and cancer differed by race sex. Adults enrolled Cancer Prevention Study II 1982/1983 were followed for through 2012 (n = 580,182). Sex- race-specific multivariable-adjusted hazard ratios 95% confidence intervals estimated a 5-point score risk death....
Prospective studies are needed to examine the temporal relationship between oral human papillomavirus (HPV) detection and risk of head neck squamous cell carcinoma (HNSCC). Moreover, cavity contains a wide spectrum α-, β-, γ-HPV types, but their association with HNSCC is unknown.To prospectively associations in incident HNSCC.A nested case-control study was carried out among 96 650 participants, cancer free at baseline, available mouthwash samples 2 prospective cohort studies: (1) American...
Multiple myeloma (MM) is a rare but highly fatal malignancy. High body weight associated with this cancer, several questions remain regarding the aetiological relevance of timing and location weight. To address these questions, we conducted pooled analysis MM mortality using 1·5 million participants (including 1388 deaths) from 20 prospective cohorts in National Cancer Institute Cohort Consortium. Proportional hazards regression was used to calculate multivariate hazard ratios (HRs) 95%...
Abstract Several chronic lymphocytic leukaemia (CLL) susceptibility loci have been reported; however, much of the heritable risk remains unidentified. Here we perform a meta-analysis six genome-wide association studies, imputed using merged reference panel 1,000 Genomes and UK10K data, totalling 6,200 cases 17,598 controls after replication. We identify nine at 1p36.11 (rs34676223, P =5.04 × 10 −13 ), 1q42.13 (rs41271473, =1.06 −10 4q24 (rs71597109, =1.37 4q35.1 (rs57214277, =3.69 −8 6p21.31...
Abstract Background Excess body weight is an established cause of postmenopausal breast cancer, but it unknown if loss reduces risk. Methods Associations between change and risk cancer were examined among women aged 50 years older in the Pooling Project Prospective Studies Diet Cancer. In 10 cohorts, assessed on three surveys was used to examine patterns over approximately (interval 1 median = 5.2 years; interval 2 4.0 years). Sustained defined as no less than kg lost that not regained 2....
This study assessed the joint association of pathogenic variants (PVs) in breast cancer (BC) predisposition genes and polygenic risk scores (PRS) with BC general population.
Previous epidemiological studies found associations between exposure to per- and polyfluoroalkyl substances (PFAS) some cancer types. Many considered highly exposed populations, so relevance less-exposed populations can be uncertain. Additionally, many only site, not histology.
In 2022, the American Cancer Society updated its guideline for cancer survivors. However, impact of post-diagnosis adherence on mortality risk those with obesity-related cancers remains unclear. This study followed nonsmoking participants from Prevention Study-II Nutrition Cohort diagnosed between 1992 and 2002 through 2020. Post-diagnosis to ACS guidelines-body mass index (BMI), physical activity, diet, alcohol consumption-was scored a scale 0 8. Cox proportional hazards regression models...
Studies of breast cancer in women and laboratory studies provide evidence that shift work involving circadian rhythm disruption is a probable human carcinogen. However, linking other factors to prostate risk limited.To examine associations schedule (i.e., rotating work, fixed night afternoon/evening work); sleep duration; insomnia frequency with mortality.The Cancer Prevention Study-II large prospective cohort study U.S. adults. Work schedule, duration, frequency, information was...
Prospective cohort studies contribute importantly to understanding the role of lifestyle, genetic, and other factors in chronic disease etiology.The American Cancer Society (ACS) recruited a new prospective study, Prevention Study 3 (CPS-3), between 2006 2013 from 35 states Puerto Rico. Enrollment took place primarily at ACS community events enrollment "drives." At sites, participants completed brief survey that included an informed consent, identifying information necessary for follow-up,...
Follicular lymphomas (FL) are characterized by BCL2 translocations, often detectable in blood years before FL diagnosis, but also observed aging healthy individuals, suggesting additional lesions required for lymphomagenesis. We directly early cooperating mutations ultradeep sequencing of prediagnostic and tissue specimens from 48 subjects who ultimately developed FL. Strikingly, CREBBP lysine acetyltransferase (KAT) domain were the most commonly precursor lesions, largely distinguished...