Jenna Lilyquist
A5038255917- BRCA gene mutations in cancer
- Nutrition, Genetics, and Disease
- Cancer Genomics and Diagnostics
- Genetic factors in colorectal cancer
- Genetic Associations and Epidemiology
- DNA Repair Mechanisms
- CRISPR and Genetic Engineering
- Pancreatic and Hepatic Oncology Research
- Ovarian cancer diagnosis and treatment
- Epigenetics and DNA Methylation
- Bioinformatics and Genomic Networks
- Skin Protection and Aging
- Cancer Cells and Metastasis
- Breast Cancer Treatment Studies
- Autophagy in Disease and Therapy
- Prostate Cancer Treatment and Research
- Animal Genetics and Reproduction
- Genomic variations and chromosomal abnormalities
- Antioxidant Activity and Oxidative Stress
- RNA Research and Splicing
- Sirtuins and Resveratrol in Medicine
- Cancer Risks and Factors
- Retinoids in leukemia and cellular processes
- Sex and Gender in Healthcare
- Indoor Air Quality and Microbial Exposure
Mayo Clinic in Arizona
2016-2022
Social and Scientific Systems (United States)
2022
Mayo Clinic in Florida
2017-2020
City of Hope
2019
American Cancer Society
2019
City Of Hope National Medical Center
2019
University of Wisconsin–Milwaukee
2019
National Center for Tumor Diseases
2018
Charité - Universitätsmedizin Berlin
2018
University Hospital Heidelberg
2018
Population-based estimates of the risk breast cancer associated with germline pathogenic variants in cancer-predisposition genes are critically needed for assessment and management women inherited variants.
Germline pathogenic variants in BRCA1 and BRCA2 predispose to an increased lifetime risk of breast cancer. However, the relevance germline other genes from multigene hereditary cancer testing panels is not well defined.To determine risks associated with predisposition genes.A study population 65 057 patients receiving genetic panels. Associations between non-BRCA1 non-BRCA2 were estimated a case-control analysis Exome Aggregation Consortium reference controls. The women underwent March 15,...
Individuals genetically predisposed to pancreatic cancer may benefit from early detection. Genes that predispose and the risks of associated with mutations in these genes are not well defined.To determine whether inherited germline predisposition increased cancer.Case-control analysis identify genes; longitudinal patients for prognosis. The study included 3030 adults diagnosed as having enrolled a Mayo Clinic registry between October 12, 2000, March 31, 2016, last follow-up on June 22, 2017....
Germline genetic testing with hereditary cancer gene panels can identify women at increased risk of breast cancer. However, those triple-negative (estrogen receptor–negative, progesterone human epidermal growth factor receptor–negative) (TNBC) cannot be identified because predisposition genes for TNBC, other than BRCA1, have not been established. The aim this study was to define the panel associated TNBC. Multigene 21 in 8753 TNBC patients performed by a clinical laboratory, and 17 2148...
Understanding the gene-specific risks for development of breast cancer will lead to improved clinical care those carrying germline mutations in predisposition genes. We sought detail spectrum and refine risk estimates known proposed susceptibility Targeted massively-parallel sequencing was performed identify copy number variants 26 or genes 2134 BRCA1/2-negative women with familial (proband a family history ovarian cancer) from largely European-Caucasian multi-institutional cohort....
Abstract Background The germline cancer predisposition genes associated with increased risk of each clinical subtype breast cancer, defined by estrogen receptor (ER), progesterone (PR), and HER2, are not well defined. Methods A total 54 555 invasive patients 56 480 tumors were subjected to hereditary multigene panel testing. Heterogeneity for across subtypes was assessed comparing mutation frequencies gene among tumor association studies between reference controls. Results Mutations in 15...
This study assessed the joint association of pathogenic variants (PVs) in breast cancer (BC) predisposition genes and polygenic risk scores (PRS) with BC general population.
Breast cancer risks conferred by many germline missense variants in the
Previous studies have shown that reproductive factors are differentially associated with breast cancer (BC) risk by subtypes. The aim of this study was to investigate associations between and BC subtypes, whether these vary age at diagnosis. We used pooled data on tumor markers (estrogen progesterone receptor, human epidermal growth factor receptor-2 (HER2)) (parity, first full-time pregnancy (FFTP) menarche) from 28,095 patients invasive 34 participating in the Breast Cancer Association...
The relevance of inherited pathogenic mutations in cancer predisposition genes pancreatic is not well understood. We aimed to assess the characteristics patients with referred for hereditary genetic testing and estimate risk associated panel-based this high-risk population.
In studies of men European ancestry, rare pathogenic variants in DNA repair pathway genes have been shown to be associated with risk aggressive prostate cancer. The contribution coding variation cancer African ancestry has not established.
Mammographic breast density, adjusted for age and body mass index, a polygenic risk score (PRS), comprised of common genetic variation, are both strong factors cancer increase discrimination models. Understanding their joint contribution will be important to more accurately predict risk. Using 3628 cases 5126 controls European ancestry from eight case-control studies, we evaluated associations 77-single nucleotide polymorphism (SNP) PRS quantitative mammographic density measures with cancer....
Abstract To evaluate the racial and ethnic differences in prevalence of germline pathogenic variants (PVs) effect race ethnicity on breast cancer (BC) risk among carriers, results multigene testing 77 900 women with BC (non-Hispanic White [NHW] = 57 003; Ashkenazi-Jewish 4798; Black 6722; Hispanic 5194; Asian 4183) were analyzed, frequency PVs each gene compared between patients (cases) race- ethnicity-matched gnomAD reference controls. Compared NHWs, BRCA1 enriched Ashkenazi-Jews Hispanics,...
Autophagy has been linked with melanoma risk and survival, but no polymorphisms in autophagy-related (ATG) genes have investigated relation to progression. We examined five single-nucleotide (SNPs) three ATG (ATG5; ATG10; ATG16L) known or suspected impact on autophagic flux an international population-based case-control study of melanoma. DNA from 911 patients was genotyped. An association identified between (GG) (rs2241880) earlier stage at diagnosis (OR 0.47; 95% Confidence Intervals (CI)...
Women with breast cancer have a 4%-16% lifetime risk of second primary cancer. Whether mutations in genes other than
Abstract Background New treatment strategies for metastatic breast cancer (mBC) are mainly driven by therapies against specific targets. BRCA mutations one of the few established actionable targets, with PARP-Inhibitors and Platinum showing high efficacy in mBC. Hereditary testing panels now broadly used identification individuals BRCA1/2 who may benefit from these therapies. Many also contain other predisposition genes involved BRCA-related DNA repair pathways, but clinical relevance remain...
The prevalence of Diabetes Type 2 is on the rise internationally. Currently, Fasting Plasma Glucose (FPG) and HbA1c are both used to determine if an individual diabetic or prediabetic. We aimed describe diabetes, prediabetes, glycemic control in a population-based sample elderly Hispanic non-Hispanic White participants New Mexico.To do this, we compared with FPG using Chi-Square analysis across gender ethnicity provide information for future health care policy. also performed non-parametric...
Increased risk of malignancies other than pancreatic cancer (PC) has been reported among first-degree relatives (FDRs) PC patients; however, the roles susceptibility gene mutations are unclear. We assessed for 15 cancers FDRs unselected probands.
Although ultraviolet radiation (UV) exposure from indoor tanning has been linked to an increased risk of melanoma, the role DNA repair genes in this process is unknown. We evaluated association 92 single nucleotide polymorphisms (SNPs) 20 with melanoma and among 929 patients 817 controls Minnesota Skin Health Study. Significant associations were identified for SNPs ERCC4, ERCC6, RFC1, XPC, MGMT, FBRSL1 genes; a cutoff P < 0.05. ERCC6 gene variants haplotypes interacted tanning. However, none...