A5001241328- Skin Protection and Aging
- melanin and skin pigmentation
- Autophagy in Disease and Therapy
- DNA Repair Mechanisms
- Ferroptosis and cancer prognosis
- Cutaneous Melanoma Detection and Management
- Prostate Cancer Treatment and Research
- Genetic factors in colorectal cancer
- BRCA gene mutations in cancer
- Molecular Biology Techniques and Applications
- Olfactory and Sensory Function Studies
- Hepatitis C virus research
- Glioma Diagnosis and Treatment
- Carcinogens and Genotoxicity Assessment
- Genetic Associations and Epidemiology
- RNA regulation and disease
- Oral Health Pathology and Treatment
- Cancer Mechanisms and Therapy
- Effects and risks of endocrine disrupting chemicals
- Cancer Research and Treatments
- Immune cells in cancer
- Nuclear Structure and Function
- Radiation Therapy and Dosimetry
- demographic modeling and climate adaptation
- Immune Cell Function and Interaction
Royal College of Surgeons in Ireland
2020-2022
University of New Mexico
2011-2021
New Mexico Cancer Center
2013
UNM Comprehensive Cancer Center
2013
University of Minnesota
2012
University of Michigan
2006-2008
New precision medicine therapies are urgently required for glioblastoma (GBM). However, to date, efforts subtype patients based on molecular profiles have failed direct treatment strategies. We hypothesised that interrogation of the GBM tumour microenvironment (TME) and identification novel TME-specific subtypes could inform new immunotherapy strategies.A refined validated cell population (MCP) counter method was applied >800 patient tumours (GBM-MCP-counter). Specifically, partition around...
Abstract Many people frequently tan indoors despite being aware of the increased risk melanoma. Ultraviolet radiation is hypothesized to modify biological reward pathways, for example, through dopamine neurotransmitter system, reinforce tanning behaviour. In this pilot study, we relied on questionnaire and DNA data from a recently completed case–control study examine 67 single‐nucleotide polymorphisms ( SNP s) related haplotypes in five receptor drug metabolism genes relation indoor among...
Melanocytic naevi are an important risk factor for melanoma. Naevi with distinct dermoscopic patterns can differ in size, distribution and host pigmentation characteristics.We examined MC1R 85 other candidate loci a cohort of children to test the hypothesis that development type modulated by genetic variants.Buccal DNAs were obtained from 353 fifth graders (mean age 10·4 years). Polymorphisms chosen based on known or anticipated role Associations between single-nucleotide polymorphisms...
A rare germline variant in the microphthalmia-associated transcription factor (MITF) gene, E318K, has been reported as associated with melanoma. We confirmed its independent association melanoma [odds ratio (OR) 1.7, 95% confidence interval (CI) = 1.1, 2.7, P 0.03]; adjusted for age, sex, center, age × sex interaction, pigmentation characteristics, family history of melanoma, and nevus density). In stratified analyses, carriage MITF E318K was more strongly people dark hair than fair (P 0.03)...
Abstract The Nijmegen breakage syndrome 1 (NBS1) gene, which participates in DNA double strand break repair, has been postulated to be a susceptibility factor for number of cancers, including prostate cancer. Numerous mutations have identified NBS1, the founder mutation 657del5. In this study, analyses were done determine whether NBS1 are associated with an increased risk frequency 657del5 both familial cancer cases (1,819 affected men among 909 families) and sporadic (1,218 men) collected...
Melanocortin-1 receptor (MC1R) is a marker of melanoma risk in populations European ancestry. However, MC1R effects on survival are much less studied. We investigated associations between variation at and an international, population-based series single primary patients enrolled into the Genes, Environment, Melanoma study. genotype data was available for 2,200 participants with first incident diagnosis. estimated association genotypes melanoma-specific (i.e., death caused by melanoma)...
Limited translational genomic research currently exists to guide the availability, comprehension, and appropriate use of personalized genomics in diverse general population subgroups. Melanoma skin cancers are preventable, curable, common population, disproportionately increasing Hispanics.Variants melanocortin-1 receptor (MC1R) gene present approximately 50% major factors determining sun sensitivity, confer a 2-to-3-fold increase melanoma risk even populations with darker skin. Therefore,...
Autophagy has been linked with melanoma risk and survival, but no polymorphisms in autophagy-related (ATG) genes have investigated relation to progression. We examined five single-nucleotide (SNPs) three ATG (ATG5; ATG10; ATG16L) known or suspected impact on autophagic flux an international population-based case-control study of melanoma. DNA from 911 patients was genotyped. An association identified between (GG) (rs2241880) earlier stage at diagnosis (OR 0.47; 95% Confidence Intervals (CI)...
Abstract Purpose: A genome-wide scan of 175 hereditary prostate cancer families from the University Michigan Prostate Cancer Genetics Project provided evidence linkage to 17q markers near BRCA1 gene. To examine possibility that germ-line mutations were associated with cancer, individuals 93 chromosome screened for mutations. Experimental Design: One individual each families, majority three or more cases denaturing high-performance liquid chromatography (HPLC). Fragments exhibiting HPLC...
Objectives A cross-sectional epidemiological study explored genetic susceptibility to oral precancer and cancer in Puerto Rico (PR). Materials Methods Three hundred three individuals with a benign condition, (oral epithelial hyperplasia/hyperkeratosis, dysplasia), or squamous cell carcinoma (SCCA) were identified via PR pathology laboratories. standardized, structured questionnaire obtained information on variables; buccal cells collected for analysis. Genotyping was performed using Taqman®...
Background Hispanics are known to be an extremely diverse and genetically admixed ethnic group. The lack of methodologies control for ethnicity the unknown admixture in complex study populations has left a gap understanding certain cancer disparity issues. Incidence rates oral pharyngeal (OPC) Puerto Rico among highest Western Hemisphere. We conducted epidemiological examine risk protective factors, addition possible genetic susceptibility components, precancer Rico. Methodology/Principal...
Although ultraviolet radiation (UV) exposure from indoor tanning has been linked to an increased risk of melanoma, the role DNA repair genes in this process is unknown. We evaluated association 92 single nucleotide polymorphisms (SNPs) 20 with melanoma and among 929 patients 817 controls Minnesota Skin Health Study. Significant associations were identified for SNPs ERCC4, ERCC6, RFC1, XPC, MGMT, FBRSL1 genes; a cutoff P < 0.05. ERCC6 gene variants haplotypes interacted tanning. However, none...
Abstract The kin-cohort design has been proposed as an alternative to traditional case-control and cohort measures evaluate inherited susceptibility cancer in population-based studies. Here, we used this prostate associated with APC I1307K using data from the Molecular Epidemiology of Colorectal Cancer study. Two techniques were compare incidence carriers. First, compared relatives mutation carriers noncarriers standard for survival analysis. Second, marginal maximum likelihood method...
The Melanocortin 1 Receptor (MC1R) contributes to pigmentation, an important risk factor for developing melanoma. Evaluating SNPs in MC1R and association with race/ethnicity, skin type, perceived cancer a New Mexico (NM) population will elucidate the role of multicultural population.We genotyped 191 NMs attending primary care clinic Albuquerque. We obtained individuals' self-identified risk. defined genetic as carriage any one or more nine most common MC1R.We found that SNP, R163Q...
Few risk factors for glioma have been identified other than ionizing radiation. The alkylating agent acrylamide is a compound found in both occupational and the general environment as one of forty known or suspected neurocarcinogens animal models. mutagen sensitivity assay (MSA) has used to indirectly show reduced DNA repair capacity upon exposure radiation those with compared controls. In this study, MSA was assess its applicability case-control study test hypothesis that subjects may lower...