A5053600172- Lipoproteins and Cardiovascular Health
- Sphingolipid Metabolism and Signaling
- Antiplatelet Therapy and Cardiovascular Diseases
- Genomics and Rare Diseases
- Genetic factors in colorectal cancer
- BRCA gene mutations in cancer
- Pharmacogenetics and Drug Metabolism
- Cancer Genomics and Diagnostics
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cancer, Lipids, and Metabolism
- Cardiomyopathy and Myosin Studies
- Connective tissue disorders research
- Neonatal Health and Biochemistry
- Receptor Mechanisms and Signaling
- Coronary Interventions and Diagnostics
- Aortic Disease and Treatment Approaches
- Acute Myocardial Infarction Research
- Cardiac Valve Diseases and Treatments
- Protein Kinase Regulation and GTPase Signaling
- Genomic variations and chromosomal abnormalities
- Biotechnology and Related Fields
- Lipid Membrane Structure and Behavior
- Methemoglobinemia and Tumor Lysis Syndrome
- PI3K/AKT/mTOR signaling in cancer
- Williams Syndrome Research
Mayo Clinic
2015-2025
Mayo Clinic in Arizona
2016-2025
WinnMed
2009-2025
Mayo Clinic in Florida
2009-2025
University of Ottawa
2021
Genomics (United Kingdom)
2019-2021
Institute for Transfusion Medicine
2019
University of Minnesota Rochester
2008-2016
Cleveland Clinic
1999-2003
Cleveland State University
1999-2003
<h3>Importance</h3> After percutaneous coronary intervention (PCI), patients with<i>CYP2C19*2</i>or<i>*3</i>loss-of-function (LOF) variants treated with clopidogrel have increased risk of ischemic events. Whether genotype-guided selection oral P2Y12 inhibitor therapy improves outcomes is unknown. <h3>Objective</h3> To determine the effect a strategy on in<i>CYP2C19</i>LOF carriers after PCI. <h3>Design, Setting, and Participants</h3> Open-label randomized clinical trial 5302 undergoing PCI...
Objective— Ceramides are sphingolipids involved with cellular signaling. Synthesis of ceramides occurs in all tissues. accumulate within tissues and the blood plasma during metabolic dysfunction, dyslipidemia, inflammation. Elevations predictive cardiovascular mortality. We sought to verify utility concentrations 4 ceramides: N-palmitoyl-sphingosine [Cer(16:0)], N-stearoyl-sphingosine [Cer(18:0)], N-nervonoyl-sphingosine [Cer(24:1)], N-lignoceroyl-sphingosine [Cer(24:0)] predicting major...
Sphingosylphosphorylcholine (SPC) and lysophosphatidylcholine (LPC) are bioactive lipid molecules involved in numerous biological processes. We have recently identified ovarian cancer G protein-coupled receptor 1 (OGR1) as a specific high affinity for SPC, G2A with LPC, but low SPC. Among receptors, GPR4 shares highest sequence homology OGR1 (51%). In this work, we not only another also albeit of lower affinity. Both SPC LPC induce increases intracellular calcium concentration GPR4-,...
The signaling pathways that lysophosphatidic acid (LPA) and sphingosine-1-phosphate (S1P) use to activate Akt in ovarian cancer cells are investigated here. We show for the first time, with of both pharmacological genetic inhibitors, kinase activity S473 phosphorylation induced by LPA S1P requires mitogen-activated protein (MAP) (MEK) p38 MAP kinase, MEK is likely be upstream p38, HEY cells. requirement cell type- stimulus-specific. Among 12 lines we tested, 11 respond all responsive require...
Sphingosine‐1‐phosphate (S1P) is a bioactive lipid molecule. It stimulates the growth of some cells, but inhibits others. In this study, we describe detection sub‐μM to μM concentrations S1P in ascitic fluids patients with ovarian cancer. cancer cells cultured vitro, exhibited dual effect on and/or survival. (10 μM) induced cell death when were suspension stimulated attached. The calcium‐dependent induction by apparently associated its inhibitory attachment and adhesion. (10–30 also...
Akt plays a pivotal role in cell survival and tumorigenesis. We investigated the potential interaction between sphingosine-1-phosphate (S1P) platelet-derived growth factor (PDGF) signaling pathway. Using mouse embryonic fibroblasts (MEFs) from S1P receptor knockout mice, we show here that S1P3 was required for S473 phosphorylation of by S1P. In addition, S1P-stimulated activation Akt, but not ERK, blocked PDGF (PDGFR)-specific inhibitor, AG1296, suggesting S1P3-mediated specific crosstalk...
Lysophospholipids (LPLs), including glycerol- and sphingoid-based lipids, stimulate cell signaling play important pathophysiological roles in humans other animals. These LPLs include lysophosphatidic acid (LPA), lysophosphatidylinositol (LPI), lysophosphatidylcholine (LPC), lysophosphatidylserine (LPS), sphingosine-1-phosphate (S1P), sphingosylphosphorylcholine (SPC). Analyses of human body fluids from subjects with different conditions reveal not only the relevance diseases, but also their...
Depending upon who you ask, may get very different answers to the question of “what does ‘big data’ mean you?” Most obviously, term “big data” applies high-resolution omics data for which we rely on various bioinformatics tools make conclusions how improve patient care. However, also readily refers reported every day as a part clinical laboratory testing environment, and more broadly information generated in electronic health records (EHRs).11 There are several practical IT solutions...