A5003437490- Ovarian cancer diagnosis and treatment
- Endometriosis Research and Treatment
- Uterine Myomas and Treatments
- Endometrial and Cervical Cancer Treatments
- Pregnancy-related medical research
- Reproductive System and Pregnancy
- Cervical Cancer and HPV Research
- Ovarian function and disorders
- Radiomics and Machine Learning in Medical Imaging
- Cancer, Lipids, and Metabolism
- Cancer-related molecular mechanisms research
- Menstrual Health and Disorders
- Monoclonal and Polyclonal Antibodies Research
- Glycosylation and Glycoproteins Research
- Assisted Reproductive Technology and Twin Pregnancy
- Cancer Immunotherapy and Biomarkers
- Cancer Risks and Factors
- Intraperitoneal and Appendiceal Malignancies
- Global Cancer Incidence and Screening
- Sex and Gender in Healthcare
- Cancer Genomics and Diagnostics
- MicroRNA in disease regulation
- Surgical Simulation and Training
- Genetic factors in colorectal cancer
- Genital Health and Disease
Brigham and Women's Hospital
2016-2025
Harvard University
2016-2025
Boston Children's Hospital
2014-2025
Dana-Farber/Boston Children's Cancer and Blood Disorders Center
2022-2025
J. Willard and Alice S. Marriott Foundation
2020
Vanderbilt University Medical Center
2020
Michigan State University
2020
Stanford University
2020
Endometriosis
2020
University of Pennsylvania
2017
<h3>Context</h3> Transition to menopause has long been considered a period of increased risk for depressive symptoms. However, it is unclear whether this one major disorder, particularly women who have not had previous episode depression. <h3>Objective</h3> To examine the association between menopausal transition and onset first lifetime depression among with no history mood disturbance. <h3>Design</h3> Longitudinal, prospective cohort study. <h3>Setting</h3> A population-based...
Studies have shown that women with vulvodynia are more psychologically distressed than without vulvodynia. These studies, however, not effectively established temporal associations between diagnosed psychiatric disorders and vulvodynia.The Structured Clinical Interview for DSM-IV Axis I Disorders (SCID) was administered to 240 case-control pairs of Interviews age at first onset mood anxiety disorder. Age information used determine whether the episode and/or antecedent or subsequent symptoms....
Abstract A panel of biomarkers may improve predictive performance over individual markers. Although many biomarker panels have been described for ovarian cancer, few studies used prediagnostic samples to assess the potential early detection. We conducted a multisite systematic evaluation using serum from Prostate, Lung, Colorectal, and Ovarian Cancer (PLCO) screening trial. Using nested case–control design, levels 28 were measured laboratory-blinded in 118 obtained before cancer diagnosis...
The goal of this study is to obtain updated surveillance statistics for hysterectomy procedures in the United States and identify factors associated with undergoing a minimally invasive approach hysterectomy.A cross-sectional analysis 2009 Nationwide Inpatient Sample was performed. Subjects included all women aged 18 years or older who underwent any type. Logistic regression multivariate analyses were performed assess proportion hysterectomies by various routes, as well surgery...
Abstract Purpose: The objective was to identify and characterize low molecular weight proteins/peptides in urine their posttranslational modifications that might be used as a screening tool for ovarian cancer. Experimental Design: Urine samples collected preoperatively from postmenopausal women with cancer benign conditions nonsurgical controls were analyzed by surface-enhanced laser desorption/ionization mass spectrometry two-dimensional gel electrophoresis. Selected proteins profiles...
ObjectiveTo harmonize standard operating procedures (SOPs) and standardize the recording of associated data for collection, processing, storage human tissues relevant to endometriosis.DesignAn international collaboration involving 34 clinical/academic centers three industry collaborators from 16 countries on five continents.SettingIn 2013, two workshops were conducted followed by global consultation, bringing together 54 leaders in endometriosis research sample processing around...
Is there a relationship between body mass index (BMI), shape and endometriosis?Endometriosis is inversely associated with early adult BMI may correlate peripheral fat distribution.The literature suggests an inverse relation endometriosis BMI, although few studies have specifically explored this association in depth.Prospective cohort study using data collected from 116 430 female nurses September 1989 to June 2011 as part of the Nurses' Health Study II cohort. PARTICIPANTS/MATERIALS, METHODS...
Recent studies posit a role for non-coding RNAs in epithelial ovarian cancer (EOC). Combining small RNA sequencing from 179 human serum samples with neural network analysis produced miRNA algorithm diagnosis of EOC (AUC 0.90; 95% CI: 0.81–0.99). The model significantly outperformed CA125 and functioned well regardless patient age, histology, or stage. Among 454 patients various diagnoses, the had 100% specificity cancer. After using 325 to adapt qPCR measurements, was validated 51...
Do reproductive risk factor associations differ across subgroups of invasive epithelial ovarian cancer (EOC) defined by the dualistic model (type I/II) or a histologic pathway-based classification? Associations with parity, history endometriosis, tubal ligation and hysterectomy were found to in context type I/II pathways classification cancer. Shared molecular alterations candidate precursor lesions suggest that tumor histology grade may be used classify tumors into likely etiologic...
Sera from patients with ovarian cancer contain autoantibodies (AAb) to tumor-derived proteins that are potential biomarkers for early detection. To detect AAb, we probed high-density programmable protein microarrays (NAPPA) expressing 5177 candidate tumor antigens sera serous (n = 34 cases/30 controls) and measured bound IgG. Of these, 741 were selected an independent set of 60 cases/60 controls). Twelve autoantigens identified sensitivities ranging 13 22% at >93% specificity. These retested...
Abstract Purpose: About 60% of ovarian cancers are diagnosed at late stage, when 5-year survival is less than 30% in contrast to 90% for local disease. This has prompted search early detection biomarkers. For initial testing, specimens taken months or years before cancer diagnosis the best source information evaluate Here we most promising screening biomarkers prospectively collected samples from European Prospective Investigation into Cancer and Nutrition study. Experimental Design: We...
Abstract Many cancers, including ovarian, overexpress epithelial mucin (MUC1) and promote anti-MUC1 antibodies that may correlate with more favorable prognosis. By extension, risk for ovarian cancer might be reduced by preexisting MUC1-specific immunity. We measured in 705 control women, identified events predicting antibodies, estimated comparing profiles of generating controls those 668 cases. Factors included oral contraceptive use, breast mastitis, bone fracture or osteoporosis, pelvic...
This study examined the value of serum p53 autoantibodies (p53-AAb) as detection and prognostic biomarkers in ovarian cancer.p53-AAb were detected by ELISA sera obtained preoperatively from women undergoing surgery for a pelvic mass. group included subsequently diagnosed with invasive serous cancer (n = 60), nonserous cancers 30), benign disease 30). Age-matched controls selected general population 120). Receiver operating characteristic curves constructed to compare values p53-AAb, CA 125,...
Abstract Several recent studies have evaluated the association between dietary flavonoid intake and ovarian cancer risk, all reported significant or suggestive inverse associations with certain flavonoids subclasses; however, most of these were small to moderate in size. We, therefore, examined this a large, population‐based case‐control study. We calculated 5 common (myricetin, kaempferol, quercetin, luteolin, apigenin), as well total flavonoids, for 1,141 cases 1,183 frequency‐matched...
BACKGROUNDAn inverse association between adult body mass index (BMI) and risk of endometriosis has frequently been reported. However, the size during childhood early adulthood is not as well documented.