A5063029973- Glioma Diagnosis and Treatment
- Brain Metastases and Treatment
- Prostate Cancer Treatment and Research
- Radiomics and Machine Learning in Medical Imaging
- Cancer-related cognitive impairment studies
- HER2/EGFR in Cancer Research
- Histone Deacetylase Inhibitors Research
- Cancer Research and Treatments
- Lung Cancer Research Studies
- Cancer Immunotherapy and Biomarkers
- Colorectal Cancer Treatments and Studies
- Genetic Associations and Epidemiology
- Sexual Differentiation and Disorders
- Gene expression and cancer classification
- Breast Cancer Treatment Studies
- Cancer Treatment and Pharmacology
- Cancer, Hypoxia, and Metabolism
- Hepatocellular Carcinoma Treatment and Prognosis
- Molecular Biology Techniques and Applications
- Meningioma and schwannoma management
- Virus-based gene therapy research
- Advanced Radiotherapy Techniques
- PARP inhibition in cancer therapy
- Prostate Cancer Diagnosis and Treatment
- Medical Imaging Techniques and Applications
Mayo Clinic
2014-2024
The University of Texas Southwestern Medical Center
2022-2024
Mayo Clinic in Florida
2013-2024
University of Calgary
2024
North Carolina State University
2022-2023
Hamilton Medical Center
2023
Alliance Data (United States)
2014-2022
Southwestern Medical Center
2022
Quantitative BioSciences
2021
WinnMed
2011-2021
<h3>Importance</h3> Whole brain radiotherapy (WBRT) significantly improves tumor control in the after stereotactic radiosurgery (SRS), yet because of its association with cognitive decline, role treatment patients metastases remains controversial. <h3>Objective</h3> To determine whether there is less deterioration at 3 months SRS alone vs plus WBRT. <h3>Design, Setting, and Participants</h3> At 34 institutions North America, 1 to were randomized receive or WBRT between February 2002 December...
Purpose To develop a genomic signature that predicts benefit from trastuzumab in human epidermal growth factor receptor 2–positive breast cancer. Patients and Methods DASL technology was used to quantify mRNA samples 1,282 patients enrolled onto the Combination Chemotherapy With or Without Trastuzumab Treating Women Breast Cancer (North Central Treatment Group N9831 [NCCTG-N9831]) adjuvant trial. Cox proportional hazard ratios (HRs), adjusted for significant clinicopathologic risk factors,...
Abstract Measles virus (MV) vaccine strains have shown significant preclinical antitumor activity against glioblastoma (GBM), the most lethal glioma histology. In this first in human trial (NCT00390299), a carcinoembryonic antigen-expressing oncolytic measles derivative (MV-CEA), was administered recurrent GBM patients either at resection cavity (Group A), or, intratumorally on day 1, followed by second dose after tumor 5 B). A total of 22 received study treatment, 9 Group and 13 B. Primary...
Many men develop a rising PSA after initial therapy for prostate cancer. While some of these will local or metastatic recurrence that warrants further therapy, others have no evidence disease progression. We hypothesized an expression biomarker panel can predict which with would benefit from therapy.A case-control design was used to test the association gene outcome. Systemic (SYS) progression cases were post-prostatectomy who developed systemic within 5 years recurrence. controls matched...
Triple-negative (TN) breast cancer is an aggressive subtype of associated with a unique set epidemiologic and genetic risk factors. We conducted two-stage genome-wide association study TN (stage 1: 1529 cases, 3399 controls; stage 2: 2148 1309 controls) to identify loci that influence risk. Variants in the 19p13.1 PTHLH showed significant associations (P < 5 × 10−8) 1 2 combined. Results also suggested substantial enrichment significantly variants among single nucleotide polymorphisms (SNPs)...
We hypothesized that vertical blockade of VEGF signaling by combining bevacizumab with sorafenib in patients recurrent glioblastoma would result a synergistic therapeutic effect. also investigated whether VEGF, VEGFR2 and hypoxia-inducible factor-1α single-nucleotide polymorphisms (SNP), circulating biomarkers angiogenesis, MRI markers such as apparent diffusion coefficient (ADC) are correlated treatment efficacy and/or toxicity.Patients received (5 mg/kg every 2 weeks) (200 mg twice day,...
BackgroundThe mammalian target of rapamycin (mTOR) functions within the phosphatidylinositol-3 kinase (PI3K)/Akt pathway as a critical modulator cell survival. This clinical trial evaluated combination mTOR inhibitor everolimus with conventional temozolomide (TMZ)-based chemoradiotherapy.
LBA4 Background: WBRT significantly improves tumor control in the brain after SRS, yet role of adjuvant remains undefined due to concerns regarding neurocognitive risks. Methods: Patients with 1-3 metastases, each < 3 cm by contrast MRI, were randomized SRS alone or + and underwent cognitive testing before treatment. The primary endpoint was progression (CP) defined as decline > 1 SD from baseline any 6 tests at months. Time CP estimated using cumulative incidence adjusting for...
Vorinostat, a histone deacetylase (HDAC) inhibitor, has shown radiosensitizing properties in preclinical studies. This open-label, single-arm trial evaluated the maximum tolerated dose (MTD; phase I) and efficacy (phase II) of vorinostat combined with standard chemoradiation newly diagnosed glioblastoma. Patients received oral (300 or 400 mg/day) on days 1–5 weekly during temozolomide chemoradiation. Following 4- to 6-week rest, patients up 12 cycles adjuvant (400 1–7 15–21 each 28-day...
Abstract Background We report the analysis involving patients treated on initial CODEL design. Methods Adults (&gt;18) with newly diagnosed 1p/19q World Health Organization (WHO) grade III oligodendroglioma were randomized to radiotherapy (RT; 5940 centigray ) alone (arm A); RT concomitant and adjuvant temozolomide (TMZ) B); or TMZ C). Primary endpoint was overall survival (OS), arm A versus B. Secondary comparisons performed for OS progression-free (PFS), comparing pooled arms TMZ-alone...
Attenuated measles virus (MV) strains are promising agents currently being tested against solid tumors or hematologic malignancies in ongoing phase I and II clinical trials; factors determining oncolytic virotherapy success remain poorly understood, however. We performed RNA sequencing gene set enrichment analysis to identify pathways differentially activated MV-resistant (n = 3) -permissive 2) derived from resected human glioblastoma (GBM) specimens propagated as xenografts (PDX). Using a...
Long-term outcomes of radiotherapy are important in understanding the risks and benefits therapies for patients with brain metastases.To determine how use postoperative whole-brain (WBRT) or stereotactic radiosurgery (SRS) is associated quality life (QOL), cognitive function, intracranial tumor control long-term survivors 1 to 4 metastases.This secondary analysis a randomized phase 3 clinical trial included 48 institutions US Canada. Adult resected metastases but limited those metastasis...
Abstract Purpose: The RANO criteria have not been assessed using outcome data from prospective trials. We examined the radiologic of patients with recurrent glioblastoma randomized phase II trial (AVF3708g) to determine effect including T2/FLAIR evaluation as per on measurements objective response rates (ORRs) and progression-free survival (PFS) compared assessment based contrast enhancement (Macdonald criteria). Experimental Design: ORRs median PFS were determined those obtained Macdonald...
Src signaling is markedly upregulated in patients with invasive glioblastoma (GBM) after the administration of bevacizumab. The family kinase inhibitor dasatinib has been found to effectively block bevacizumab-induced glioma invasion preclinical models, which led hypothesis that combining bevacizumab could increase efficacy recurrent GBM.After completion phase 1 component, 2 trial (ClinicalTrials.gov identifier NCT00892177) randomized GBM 2:1 receive 100 mg oral twice daily (arm A) or...
Clinical immunotherapy approaches are lacking efficacy in the treatment of glioblastoma (GBM). In this study, we sought to reverse local and systemic GBM-induced immunosuppression using Helicobacter pylori neutrophil-activating protein (NAP), a potent TLR2 agonist, as an immunostimulatory transgene expressed oncolytic measles virus (MV) platform, retargeted allow viral entry through urokinase-type plasminogen activator receptor (uPAR). While single-agent murine anti-PD1 or repeat situ...
The prognosis for patients with glioblastoma is poor following standard therapy surgical resection, radiation, temozolomide, and tumor-treating fields.
Findings from the human epidermal growth factor receptor 2 (HER2) -positive National Surgical Adjuvant Breast and Bowel Project (NSABP) B31 trial suggested that MYC/HER2 coamplification (> 5.0 copies/nucleus) was associated with additional benefit adjuvant trastuzumab in patients early-stage breast cancer. To further explore this relationship, we investigated associations between MYC amplification disease-free survival (DFS) a similar HER2-positive cancer trial-North Central Cancer Treatment...
BACKGROUND Mitogen‐activated protein kinase (MAPK) activation and mammalian target of rapamycin (mTOR)‐dependent signaling are hallmarks glioblastoma. In the current study, authors conducted a phase 1/2 study sorafenib (an inhibitor Raf vascular endothelial growth factor receptor 2 [VEGFR‐2]) mTOR temsirolimus in patients with recurrent METHODS Patients glioblastoma who developed disease progression after surgery or radiotherapy plus temozolomide ≤2 prior chemotherapy regimens were eligible....
The optimal radiation dose for adult supratentorial low-grade glioma is unknown. aim of this study was to provide a final update on oncologic and cognitive outcomes high-dose versus low-dose glioma.Between 1986 1994, 203 patients with were randomized (1:1) 50.4 Gy in 28 fractions 64.8 36 after any degree resection.For all patients, median overall survival (OS) 8.4 years (95% CI: 7.2-10.8). Median progression-free (PFS) 5.2 4.3-6.6). follow-up 17.2 the 33 still alive. High-dose did not...
Aberrant coregulator expression that occurs during prostate cancer (PCa) progression correlates with poor prognosis and aggressive disease. This has been attributed to the ability regulate androgen receptor-mediated transcription. We have shown previously androgenic milieu regulates of coactivators p300 FHL2, severe consequences for PCa cell proliferation receptor transcriptional activity. To determine extent dependency genes, we designed a cDNA-mediated annealing, selection, extension,...
Abstract The androgen receptor (AR) is the principal target for treatment of non–organ-confined prostate cancer (PCa). Androgen deprivation therapies (ADT) directed against AR ligand–binding domain do not fully inhibit androgen-dependent signaling critical PCa progression. Thus, information that could direct development more effective ADTs desired. Systems and bioinformatics approaches suggest considerable variation exists in mechanisms by which regulates expression effector genes, pointing...
Object Second-generation antiepileptic drugs (AEDs) are increasingly used in the care of patients with glioma. There is little data on how this practice compares use traditional AEDs population. This noninferiority analysis seizure outcomes and side effects glioma treated phenytoin levetiracetam monotherapy. Methods The authors retrospectively reviewed records 500 consecutive who were clinical trials from 2001 to 2008 at 3 Mayo Clinic campuses. To be eligible for study, these had have least...