A5054111858- Music Therapy and Health
- Breast Cancer Treatment Studies
- Cancer Cells and Metastasis
- Maternal Mental Health During Pregnancy and Postpartum
- Cancer Genomics and Diagnostics
- Cancer Risks and Factors
- Cancer Treatment and Pharmacology
- HER2/EGFR in Cancer Research
- Maternal and Perinatal Health Interventions
- Endometriosis Research and Treatment
- Advanced Breast Cancer Therapies
- Metastasis and carcinoma case studies
- Cancer-related Molecular Pathways
- Infant Development and Preterm Care
- COVID-19 Impact on Reproduction
- Neuroscience and Music Perception
- Colorectal Cancer Treatments and Studies
- Cancer survivorship and care
- Shoulder Injury and Treatment
- Pain Management and Placebo Effect
- Uterine Myomas and Treatments
- Pediatric Pain Management Techniques
- Shoulder and Clavicle Injuries
- Family and Patient Care in Intensive Care Units
- Attachment and Relationship Dynamics
Helios Universitätsklinikum Wuppertal
2016-2023
University Hospital Augsburg
2020-2023
St. Josef Krankenhaus
2023
Witten/Herdecke University
2017-2022
Heinrich Heine University Düsseldorf
2010-2020
Düsseldorf University Hospital
2009-2019
Heidelberg University
2010-2019
Ludwig-Maximilians-Universität München
2008-2019
Luisenkrankenhaus
2009-2019
University Hospital Heidelberg
2019
Circulating tumor cells (CTCs) have been shown to predict reduced survival outcomes in metastatic breast cancer.CTCs were analyzed 2026 patients with early cancer before adjuvant chemotherapy and 1492 after using the CellSearch System. After immuno-magnetic enrichment for expressing epithelial-cell adhesion molecule, CTCs defined as nucleated cytokeratin lacking CD45. The followed a median of 35 months (range = 0-54). Kaplan-Meier analyses log-rank test used analyses. All statistical tests...
Significance The infrequent detection of circulating tumor cells (CTCs) has hindered their clinical implication and potential use in the sense a “liquid biopsy” for cancer diagnosis therapy. Hypothesizing that limited blood volume commonly used CTC analysis (1–10 mL) accounts variable rates, we leukapheresis to screen large volumes CTCs. This enabled more reliable CTCs at high frequency even nonmetastatic patients. Thus, diagnostic may facilitate routine as biomarkers personalized medicine....
The COVID-19 vaccination is probably the most important source to fight pandemic. However, recommendations and possibilities for pregnant breastfeeding women are inconsistent dynamically changing.
Stress and anxiety during pregnancy childbirth have negative consequences for both mother child. There are indications that music has a positive effect in this situation. The present study investigates the influence of caesarean on stress expectant mother. SAMBA is single-centre, controlled, randomized including 304 patients. Women intervention group heard via loudspeakers from one four self-selected genres. control had standard treatment without music. was performed regional Anesthesia. At...
Abstract Purpose Stress and impaired mother–infant bonding during pregnancy can lead to adverse effects for the expectant mother unborn child. The present study investigates whether a prenatal music singing intervention improve maternal well-being as well bonding. Methods A total of 172 pregnant women took part in this prospective, randomised, three-armed (music, or control group) study. Depressive symptoms, self-efficacy, were assessed with visual analogue scales questionnaires before phase...
Cohort trials have shown evidence that obesity and a low level of physical activity are not only associated with higher risk developing breast cancer, but also an increased for recurrence reduced survival in cancer patients. The SUCCESS C study is the first European trial to evaluate effect intensive lifestyle intervention program on disease-free women early examine predictive value selected biomarker candidates. A total 3,547 early-stage, Her2/neu-negative will be included. randomization...
Women undergoing elective caesarean section experience anxiety. However, course, extent and duration of anxiety have not been investigated yet. This study aimed to explore levels during the course day surgery by employing comparing subjective as well objective measures. By examining their correlation it is intended give methodological support for interventional studies.This a monocentric, prospectively planned in which 47 women with an indication primary took part. Anxiety were evaluated...
In recent years, the effect of music interventions and therapy has experienced increased attention in literature. It been shown that positive effects on cognitive physical performance, such as concentration endurance, well psychological parameters, anxiety relaxation. Studies within context medicine particular are increasingly indicating may be used an intervention for relief against anxiety, stress pain. Music is therefore seen actual practice a supplement to conventional pharmacological...
Postpartum depression is fairly common in new mothers and moreover associated with impaired bonding poor maternal well-being. The aim of the present study was to investigate impact a mother-infant singing intervention within first three months after birth on well-being, depressive symptoms bonding.120 women who were recruited at maternity ward University Clinic Düsseldorf took part this prospective, randomised-controlled study. Beside baseline measurement 1-3 days childbirth, symptoms,...
Abstract In order to better understand stress responses, neuroimaging studies have investigated the underlying neural correlates of stress. Amongst other brain regions, they highlight involvement prefrontal cortex. The aim present study was explore haemodynamic changes in cortex during Maastricht Acute Stress Test (MAST) using mobile functional Near-Infrared Spectroscopy (fNIRS), examining response an ecological environment. MAST includes a challenging mental arithmic task and physically...
Abstract Background: Recent trials have provided evidence that obesity and a low level of physical activity are not only associated with higher risk developing breast cancer, but also an increased for recurrence reduced survival in cancer patients (pts). The SUCCESS C study is the first randomized Phase III trial to evaluate effect intensive lifestyle intervention program, focusing on both healthy diet following adjuvant chemotherapy disease-free women early cancer. Methods: German...
Abstract Studies have shown that perioperative music interventions can reduce patients’ anxiety levels. However, in small operations like port catheter surgery evidence is sparse. The present single-blinded, randomised controlled two-armed study included 84 female patients undergoing placement who were randomly assigned to either listening during vs. no intervention. medical staff was blind group allocation. On the day of and stress levels evaluated using subjective (STAI questionnaire,...
Purpose The aim of the present study was to compare birth expectations and antenatal bonding women pregnant prior during COVID-19 pandemic.
One of the most feared complications during hysteroscopic surgery is haemodilution by absorption distension media. facet haemodilution, i.e. hyponatremia, can lead to respiratory distress, pulmonary oedema, as well cardiovascular collapse. Here we report swift recovery a 45 year, female, Caucasian patient with acute hyponatremia (74 mEq/L) and oedema employment rapid correctional strategies. The irrigation fluids, presented in this case, an inevitable side effect surgery. Utmost caution...
Evidence for the prognostic value of circulating tumor cells (CTCs) in early-stage breast cancer is swiftly increasing. An alternative approach identifying patients at risk recurrence based on detection mucin-1 (MUC1)-based marker CA27.29. Here we report association these two markers before and immediately after chemotherapy (CHT), as well 2 5 years follow-up.The SUCCESS trial compared fluorouracil, epirubicin cyclophosphamide followed by docetaxel vs. FEC plus gemcitabine, treatment with...
Abstract Background The COVID-19 pandemic has led to exceptional stress in pregnant women. aim of the present study was investigate associations maternal (pandemic-related and -unrelated), anxiety, relationship satisfaction experienced during with prenatal mother-infant attachment. Methods An online conducted evaluating pandemic-related stress, pregnancy-specific (unrelated pandemic), partnership satisfaction, maternal-fetal attachment German-speaking women second lockdown between January...
The SUCCESS-A trial is a prospective, multicenter, phase III clinical for high-risk primary breast cancer. It compares disease-free survival after randomization in patients treated with fluorouracil, epirubicin and cyclophosphamide followed by 3 cycles of docetaxel (FEC-D) that FEC gemcitabine (FEC-DG). After second were zoledronate 2 or 5 years. A total 251 centers took part the 3754 recruited over period 18 months which ended March 2007. In questionnaire-based survey we investigated impact...
Data from meta-analyses have shown taxane-containing therapies to be superior anthracycline-based treatments for high-risk breast cancer.The ADEBAR trial was a multicenter phase III in which patients with lymph node-positive cancer were prospectively randomized either sequential anthracycline-taxane or FEC120 therapy. Patients received 4× epirubicin (90 mg/m(2)) and cyclophosphamide (600 every 3 weeks (q3w), followed by docetaxel (100 q3w (EC-Doc arm), 6× (60 5-fluorouracil (500 on days 1 8...