A5044465546- Inflammatory Bowel Disease
- Microscopic Colitis
- Eosinophilic Esophagitis
- Helicobacter pylori-related gastroenterology studies
- Economic and Social Issues
- Autoimmune and Inflammatory Disorders
- Gastroesophageal reflux and treatments
- Gastrointestinal motility and disorders
- Cholesterol and Lipid Metabolism
- Immune Cell Function and Interaction
- Liver Diseases and Immunity
- Tuberculosis Research and Epidemiology
- Health, psychology, and well-being
- Stoma care and complications
- Long-Term Effects of COVID-19
- Lipoproteins and Cardiovascular Health
- Peripheral Neuropathies and Disorders
- Tryptophan and brain disorders
- Cancer Treatment and Pharmacology
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Palliative Care and End-of-Life Issues
- Genetic factors in colorectal cancer
- Systemic Lupus Erythematosus Research
- Healthcare cost, quality, practices
- Eosinophilic Disorders and Syndromes
University of Zurich
2019-2022
University Hospital of Zurich
2019-2022
Spital Limmattal
2021-2022
Università Campus Bio-Medico
2019
University of Fribourg
2008
The gene encoding for Epstein-Barr virus-induced G-protein-coupled receptor 2 (EBI2) is a risk inflammatory bowel disease (IBD). Together with its oxysterol ligand 7α,25-dihydroxycholesterol, EBI2 mediates migration and differentiation of immune cells. However, the role in colonic system remains insufficiently studied. We found increased mRNA expression oxysterol-synthesizing enzymes (CH25H, CYP7B1) inflamed colon patients ulcerative colitis mice acute or chronic dextran sulfate sodium (DSS)...
Abstract Background Abdominal pain is a frequent symptom in patients with inflammatory bowel disease (IBD) including Crohn’s (CD) and ulcerative colitis (UC). Pain can result from ongoing inflammation or functional disorders imitating irritable syndrome (IBS). Several single-nucleotide polymorphisms (SNPs) have been associated IBS. However, the impact of IBS genetics on clinical course IBD, especially levels remains unclear. Methods Data 857 UC 1206 CD Swiss IBD Cohort Study were analysed....
Single nucleotide polymorphism rs9557195 within the gene of G protein-coupled receptor Epstein-Barr virus-induced 2 (EBI2/GPR183) has been associated with increased risk for inflammatory bowel diseases (IBD). GPR183 mediates migration intestinal immune cells and promotes colitis in animal models. Here, we study surface expression associations IBD disease course.We recruited 27 patients (15 ulcerative [UC] 12 Crohn's [CD]) eight healthy volunteers (HV). was measured by FACS subtypes...
Little is known about the impact of ostomy formation in inflammatory bowel disease patients on course disease, psychological well-being, quality life and working capacity.
Abstract Background and Aims Extraintestinal manifestations are reported to occur in up 45% of inflammatory bowel disease (IBD) patients during the course disease. It is unknown whether colectomy reduces rate de novo extraintestinal (EIMs) or impacts on severity EIMs following a parallel versus independent from underlying IBD. Methods Using data Swiss Inflammatory Bowel Disease Cohort Study we aimed analyse ulcerative colitis (UC) Crohn’s (CD) undergoing cohort’s prospective follow‐up....
5-ASA remains the mainstay of therapy in mild-to-moderate ulcerative colitis (UC) enabling achievement remission between 50–75% all patients. Combination immunosuppressives (IS) has been found to be associated with a better outcome when compared monotherapy. However, concerning combination biologics, clinical practice is highly variable and evidence on potential benefit scarce. We aimed evaluate course UC patients being treated biologics vs. alone. analysed prospectively collected data from...
OBJECTIVES: We present a patient with bifacial weakness and paraesthesia subtype of Guillain-Barré syndrome (GBS), which occurred 1 month after SARS-CoV-2 infection. While GBS as complication infection has been described many times, only few cases post-COVID-19 are known to date. RESULTS: A 59-year-old man presented thoracoradicular pain, paraesthesias hands feet, well progressive bilateral facial palsy. Neurological examination revealed hyporeflexia his lower limbs hypoaesthesia feet....
The long-term tolerance to and effectiveness of heparin-induced extracorporeal LDL precipitation (HELP) in combination with lipid reducing drugs diet was tested six patient (5 males, 1 female; mean age 48 +/- 4 years). Follow-up period over 50 months, one 24 while man had a sudden cardiac death 57 weeks after starting treatment. study divided into three phases. In phase I (24 months) treatment consisted HELP conventional lipid-reducing drugs; II (12 lovastatin (80 mg daily) cholestyramine...
Summary Background Eosinophilic esophagitis is a chronic inflammatory gastrointestinal disease with high prevalence in younger, atopic males. In our clinical practice, we observed striking preponderance of patients having educational background. The purposes this study were first to assess the level education eosinophilic and second compare findings bowel disease, another immune-mediated condition tract, Swiss general population. Methods Using questionnaire, assessed adult who have attended...
Tumour necrosis factor (TNF)-inhibitors have markedly improved treatment of ulcerative colitis (UC), but loss response in the long-term remains a frequent problem. A novel anti-TNF agent, golimumab, has been introduced Switzerland for UC 2014. We aimed real-word data from 1536 patients Swiss IBD cohort study (SIBDC). treated with golimumab 2014 to 2018 were compared remaining SIBDC UC. also performed chart review subgroup assess golimumab. Among 90 (5.9% all SIBDCS UC) extensive disease (E3)...
Background: Management of venous thromboembolism (VTE) in patients with haematological malignancies (HM) and thrombocytopenia challenges clinicians because this scenario is encumbered several risks. Our panel, composed by elected members the Gruppo Italiano Malattie EMatologiche dell’Adulto (GIMEMA) Working Party on Thrombosis Haemostasis (WPHT). has recently published a consensus,reached RAND method, focused platelet cut-off for safely administering Low Molecular Weight Heparin (LMWH) adult...
Abstract Background Extraintestinal manifestations (EIM) are reported to occur in a highly variable frequency of between 6% and up 47% patient with IBD during the course disease may substantially contribute overall burden. Little is known on impact colectomy UC or CD patients EIM, neither regarding pre-existing vs. de novo EIM occurring after nor potential differences typically follow parallel independent activity underlying IBD. Methods Using data from Swiss Cohort Study (SIBDCS) we aimed...
Abstract Background Knowledge on the impact of stoma formation surgery course disease, psychological well-being, quality life (QoL) and working capacity in patients with IBD is scarce. Methods To investigate this, we analysed prospectively followed-up from Swiss inflammatory bowel disease cohort study (SIBDCS), comparing ulcerative colitis (UC) Crohn’s (CD) vs without surgery, for both temporary permanent formation. Results From a total of, 3825 SIBDCS patients, 352 were included our...
Ein 69-jähriger Patient stellt sich aufgrund von Unwohlsein und Herzrasens seit drei Tagen in der hausärztlichen Praxis vor. Ferner gibt er an, Monaten unter einer Belastungsdyspnoe ohne thorakalen Druck zu leiden.