A5029425739- Fatty Acid Research and Health
- Diet and metabolism studies
- Metabolism and Genetic Disorders
- Clinical Nutrition and Gastroenterology
- Atherosclerosis and Cardiovascular Diseases
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cardiovascular Function and Risk Factors
- Immune Cell Function and Interaction
- Acute Myocardial Infarction Research
- Eicosanoids and Hypertension Pharmacology
- Heart Failure Treatment and Management
- Adipokines, Inflammation, and Metabolic Diseases
- Diet, Metabolism, and Disease
- Cardiac Ischemia and Reperfusion
- Folate and B Vitamins Research
- Lipoproteins and Cardiovascular Health
- Cholesterol and Lipid Metabolism
- Cancer, Lipids, and Metabolism
- Peroxisome Proliferator-Activated Receptors
- S100 Proteins and Annexins
- Cytokine Signaling Pathways and Interactions
- HIV Research and Treatment
- Pulmonary Hypertension Research and Treatments
- Neuroscience of respiration and sleep
- Congenital Heart Disease Studies
University Children's Hospital Zurich
2016-2025
University of Zurich
2014-2024
Swiss Integrative Center for Human Health
2007-2023
Galveston College
2023
Société Française de Cardiologie
2023
Walter de Gruyter (Germany)
2023
St Vincent's Hospital Sydney
2023
Mirpur University of Science and Technology
2023
Azienda Ospedaliera di Padova
2023
University of Padua
2023
Oxidative stress and inflammation--two components of the natural host response to injury--constitute important etiologic factors in atherogenesis. The pro-inflammatory cytokine interleukin (IL)-1 significantly enhances atherosclerosis, however, molecular mechanisms IL-1 induction within artery wall remain poorly understood. Here we have identified oxidative stress-responsive transcription factor NF-E2-related 2 (Nrf2) as an essential positive regulator inflammasome activation IL-1-mediated...
Background— Acute myocardial infarction (AMI) is associated with inflammation. However, it remains unclear whether originates from the ruptured plaque or represents a systemic process. Methods and Results— In 42 patients AMI, balloon-based embolization protection device aspiration catheter (PercuSurge) were used during acute coronary interventions. Samples site of taken under distal balloon occlusion. Systemic samples aorta. Sera, plaques, thrombi analyzed for inflammatory markers...
In vitro studies suggest a role for c-Jun N-terminal kinases (JNKs) in proatherogenic cellular processes. We show that atherosclerosis-prone ApoE –/– mice simultaneously lacking JNK2 ( mice), but not JNK1 mice, developed less atherosclerosis than do mice. Pharmacological inhibition of JNK activity efficiently reduced plaque formation. Macrophages displayed suppressed foam cell formation caused by defective uptake and degradation modified lipoproteins showed increased amounts the...
Increased production of reactive oxygen species (ROS) and loss endothelial NO bioavailability are key features vascular disease in diabetes mellitus. The p66(Shc) adaptor protein controls cellular responses to oxidative stress. Mice lacking (p66(Shc-/-)) have increased resistance ROS prolonged life span. present work was designed investigate hyperglycemia-associated changes function a model insulin-dependent mellitus p66(Shc-/-) mouse. wild-type (WT) mice were injected with citrate buffer...
We investigated whether myeloid-related protein 8/14 complex (MRP8/14) expressed by infiltrating monocytes and granulocytes may represent a mediator early biomarker of acute coronary syndromes (ACS).Immunohistochemistry thrombi was done in 41 ACS patients. Subsequently, levels MRP8/14 were assessed systemically 75 patients with culprit lesions, stable artery disease (CAD), or normal arteries. In subset patients, measured at the site occlusion. Macrophages granulocytes, but not platelets...
Hypocretin-1 is involved in the regulation of sleep-wake cycle. The authors prospectively assessed CSF hypocretin-1 levels 44 consecutive patients with acute traumatic brain injury (TBI). Compared controls, were abnormally lower 95% moderate to severe TBI and 97% posttraumatic CT changes. deficiency after may reflect hypothalamic damage be linked frequent development disorders.
The clinical course of HIV-1 infection is highly variable among individuals, at least in part as a result genetic polymorphisms the host. Toll-like receptors (TLRs) have key role innate immunity and mutations genes encoding these been associated with increased or decreased susceptibility to infections.
ChemR23 is a G protein-coupled receptor that triggered by two ligands, the peptide chemerin and eicosapentaenoic acid-derived lipid mediator resolvin E1 (RvE1). Chemerin acts as chemoattractant for monocytes macrophages, whereas RvE1 promotes resolution of inflammation-inducing macrophage phagocytosis apoptotic neutrophils. Although ChemR23-mediated signaling plays role in mononuclear cell migration to inflamed tissue, well inflammation, its regulation different polarization states...
The fatty acid mixture of human milk is ideal for the newborn but little known about its composition in first few weeks lactation. Of special interest are levels long-chain PUFAs (LCPUFAs), since these essential newborn's development. Additionally, LCPUFAs arachidonic (AA), eicosapentaenoic (EPA) and docosahexaenoic (DHA) precursors lipid mediators which regulate inflammation.We determined 94 samples from 30 mothers over month lactation acids using GC-MS quantified HPLC-MS/MS.Over four...
Abstract Resolvin D1 (RvD1) was shown to be a potent anti-inflammatory and proresolution lipid mediator in several animal models of inflammation, but its mechanism action humans is not clear. We show that the RvD1 receptor GPR32 present on resting, proinflammatory M(LPS) alternatively activated primary human M(IL-4) macrophages, whereas TGF-β IL-6 reduce membrane expression. Accordingly, stimulation resting macrophages with 10 nM for 48 h maximally reduced secretion cytokines IL-1β IL-8;...
Abstract This meeting report presents a consensus on the biological aspects of lipid emulsions in parenteral nutrition, emphasizing unanimous support for integration emulsions, particularly those containing fish oil, owing to their many potential benefits beyond caloric provision. Lipid have evolved from simple energy sources complex formulations designed improve safety profiles and offer therapeutic benefits. The highlights critical role omega‐3 polyunsaturated fatty acids (PUFAs), notably...
Interindividual differences in CYP2D6 activity range from total absence of metabolism certain drugs to ultrafast and can produce adverse effects or lack therapeutic effect under standard therapy. Several mutations have been described the gene that abolish activity. However, four explain majority poor metabolizers. We describe single-tube assays detect these mutations.Three tetra-primer PCR were developed CYP2D6*3, *4, *6 alleles. In assays, locus is amplified directly, followed by...
Abstract Background Sphingoid bases are formed from the precursors L-serine and palmitoyl-CoA-a reaction which is catalyzed by serine-palmitoyltransferase (SPT). SPT metabolizes, besides palmitoyl-CoA also other acyl-CoAs but shows variability towards use of amino acid substrates. The enzyme able to metabolize alanine, results in formation an atypical deoxy-sphingoid base (DSB). This promiscuous activity greatly increased case sensory neuropathy HSAN1, pathologically elevated DSB levels have...
Background: Plasma concentrations of B-type natriuretic peptide (BNP) and N-terminal proBNP (NT-proBNP) are diagnostic prognostic biomarkers heart failure also increased in patients with chronic kidney disease (CKD). We examined the relevance BNP NT-proBNP as predictors CKD progression.
Abstract Background: Neuraxial blockade is used as primary anesthetic technique in one third of surgical procedures. The authors tested whether bisoprolol would protect patients at risk for cardiovascular complications undergoing surgery with spinal block. Methods: performed a double-blinded, placebo-controlled, multicenter trial to compare the effect that placebo on 1-yr composite outcome including mortality, nonfatal myocardial infarction, unstable angina, congestive heart failure, and...
Background: Impaired baseline kidney function is a well-defined risk factor for progression of chronic disease (CKD). We evaluated measured glomerular filtration rate (GFR) and the serum markers creatinine, cystatin C, β-trace protein (BTP) diagnostic accuracy in defining stage impairment as predictors CKD progression.
Objectives: The level of pancreatic stone protein/regenerating protein (PSP/reg), a secretory produced in the pancreas, increases dramatically during disease. However, after stress (e.g., anesthesia), PSP/reg levels are increased transiently animals without injury. Therefore, we aimed to determine whether is an acute-phase nonpancreatic trauma. Patients: Eighty-three polytraumatic patients damage. Measurements and Main Results: We compared serum from damage with those healthy controls (n =...
Dyslipidemia is common in women with polycystic ovary syndrome (PCOS) but its prevalence different PCOS phenotypes still largely unknown.We measured plasma lipids and lipoproteins 35 anovulatory (age: 25 +/- 6 years, BMI: 28 kg/m(2)), 15 ovulatory 30 3 kg/m(2)) 27 healthy (controls) age- BMI-matched PCOS. was diagnosed by the presence of clinical or biologic hyperandrogenism associated chronic anovulation and/or ovaries at ultrasound. In normal menses indicated low serum progesterone levels...
Oxidative stress and low-grade systemic inflammation may contribute to the pathogenesis of obesity-induced comorbidities, including nonalcoholic fatty liver disease. Increasing intake dietary antioxidants might be beneficial, but there are few data in obese children. To examine effect antioxidant supplementation on biomarkers oxidative stress, inflammation, function, we randomly assigned overweight or children adolescents (n = 44; mean ± SD age: 12.7 1.5 y) participating a lifestyle...
Cytochrome P450-dependent monooxygenase 2D6 (CYP2D6) activity can be estimated by investigating the metabolism of model drugs or genotyping most common CYP2D6 alleles. For Caucasians, allele frequencies are well investigated, and single-step assays available for genotyping, whereas analysis in mainland Chinese is limited.Two tetra-primer one allele-specific amplification assay were developed to easily genotype alleles *8, *10, *14 previously detected Asians. Applying these combination with...