A5076416009- Pancreatic function and diabetes
- Diabetes Management and Research
- Diabetes and associated disorders
- Diabetes Treatment and Management
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Metabolism, Diabetes, and Cancer
- Diet, Metabolism, and Disease
- Lipoproteins and Cardiovascular Health
- Liver Disease Diagnosis and Treatment
- Diet and metabolism studies
- Cancer, Lipids, and Metabolism
- Neuroendocrine Tumor Research Advances
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Pharmacology and Obesity Treatment
- Adipokines, Inflammation, and Metabolic Diseases
- Atherosclerosis and Cardiovascular Diseases
- Gestational Diabetes Research and Management
- Health Systems, Economic Evaluations, Quality of Life
- Cannabis and Cannabinoid Research
- Renal Transplantation Outcomes and Treatments
- Artificial Intelligence in Healthcare and Education
- Medical Practices and Rehabilitation
- Obesity, Physical Activity, Diet
- Adrenal Hormones and Disorders
- Peroxisome Proliferator-Activated Receptors
University Hospital of Zurich
2013-2023
University of Zurich
2006-2023
Universitätsklinik für Diabetologie, Endokrinologie, Ernährungsmedizin & Metabolismus
2015-2020
Christophorus Kliniken
2018
ETH Zurich
1996-2015
University of St. Gallen
2001-2015
Development Fund
2015
Center for Pediatric Endocrinology Zurich
2007-2012
Swiss Integrative Center for Human Health
2010
University of Palermo
2008
In type 2 diabetes, chronic hyperglycemia is suggested to be detrimental pancreatic β cells, causing impaired insulin secretion. IL-1β a proinflammatory cytokine acting during the autoimmune process of 1 diabetes. inhibits cell function and promotes Fas-triggered apoptosis in part by activating transcription factor NF-κB. Recently, we have shown that increased glucose concentrations also induce Fas expression human islets. The aim present study was test hypothesis may mediate deleterious...
Glucotoxicity and lipotoxicity contribute to the impaired β-cell function observed in type 2 diabetes. Here we examine effect of saturated unsaturated fatty acids at different glucose concentrations on proliferation apoptosis. Adult rat pancreatic islets were cultured onto plates coated with extracellular matrix derived from bovine corneal endothelial cells. Exposure acid (0.5 mmol/l palmitic acid) medium containing 5.5, 11.1, or 33.3 for 4 days resulted a five- ninefold increase DNA...
Glucotoxicity and lipotoxicity contribute to the impaired β-cell function observed in type 2 diabetes. Here we examine effect of saturated monounsaturated fatty acids at different glucose concentrations on human turnover secretory function. Exposure cultured islets acid and/or an elevated concentration for 4 days increased DNA fragmentation decreased proliferation. In contrast, palmitoleic or oleic did not affect induced Moreover, each prevented deleterious effects both palmitic high...
We have developed an Internet-based, interactive computer model to determine the long-term health outcomes and economic consequences of implementing different treatment policies or interventions in type 1 2 diabetes mellitus. The projects for populations, taking into account baseline cohort characteristics past history complications, current future management concomitant medications, screening strategies changes physiological parameters over time. development life expectancy,...
•It is debated whether fructose drives the metabolic syndrome or non-alcoholic fatty liver disease.•Fructose in a liquid form, within sugar-sweetened beverages, may impact metabolism.•Herein, consumption of beverages containing sucrose increased hepatic lipogenesis.•Increased lipogenic activity promote long-term perturbations. Background & aimsExcessive intake associated with de novo lipogenesis, blood triglycerides, and insulin resistance. We aimed to determine elicits specific effects on...
In autoimmune type 1 diabetes, Fas–to–Fas-ligand (FasL) interaction may represent one of the essential pro-apoptotic pathways leading to a loss pancreatic β-cells. advanced stages 2 decline in β-cell mass is also observed, but its mechanism not known. Human islets normally express FasL Fas receptor. We observed upregulation β-cells diabetic patients relative nondiabetic control subjects. vitro exposure from organ donors high glucose levels induced expression, caspase-8 and -3 activation,...
In type 2 diabetes, chronic hyperglycemia is suggested to be detrimental pancreatic beta cells, causing impaired insulin secretion. IL-1beta a proinflammatory cytokine acting during the autoimmune process of 1 diabetes. inhibits cell function and promotes Fas-triggered apoptosis in part by activating transcription factor NF-kappaB. Recently, we have shown that increased glucose concentrations also induce Fas expression human islets. The aim present study was test hypothesis may mediate...
Many factors influence the outcome of islet transplantation. As islets in early posttransplant setting are supplied with oxygen by diffusion only and a hypoxic state portal system, we tested whether small human superior to large both vitro vivo. We assessed insulin secretion quantified cell death during conditions simulating intraportal transplant environment. In clinical setting, analyzed transplanted size on production patients type 1 diabetes. Our results provide evidence that regard show...
Serial plasma samples from human volunteers obtained after intravenous administration of Escherichia coli endotoxin were analyzed for the presence circulating soluble tumor necrosis factor receptors (sTNFR). A four- to fivefold increase type (p75) and B (p55) sTNFR was observed 3 h challenge. Pretreatment with ibuprofen before injection resulted in a slight (3.87 +/- 0.2 vs. 3.27 0.3 ng/ml) temporal shift sTNFR-A release concurrent marked augmentation TNF levels (603 118 338 56 pg/ml) as...
Aim of the present Consensus Statement is to provide a comprehensive and up to-date document on pathophysiology, atherogenicity clinical significance low density liproproteins (LDL) subclasses. We sub-divided our statement in 2 sections. section I discusses measurement issues, while II focused effects drug lifestyle modifications. Suggestions for future research field are highlighted at end II. Each includes Conclusions.
Several studies support the concept of a diabetic cardiomyopathy in absence discernible coronary artery disease, although its mechanism remains poorly understood. We investigated role glucose and palmitic acid on cardiomyocyte apoptosis organization contractile apparatus. Exposure adult rat cardiomyocytes for 18 h to (0.25 0.5 mmol/l) resulted significant increase apoptotic cells, whereas increasing concentration 33.3 mmol/l up 8 days had no influence rate. However, both elevated alone or...
Adverse effects of hypercaloric, high-fructose diets on insulin sensitivity and lipids in human subjects have been shown repeatedly. The implications fructose amounts close to usual daily consumption, however, not well studied. This study assessed the effect moderate sucrose compared with glucose lipid metabolism.Nine healthy, normal-weight male volunteers (aged 21-25 years) were studied this double-blind, randomized, cross-over trial. All consumed four different sweetened beverages (600...
Although retinol-binding protein (RBP)-4 concentrations are elevated in animal models of obesity and insulin resistance (IR), the link between RBP4 IR humans is less clear. There few published data on levels overweight children, most previous studies did not control for vitamin A (VA) status and/or subclinical inflammation.The objective study was to measure serum RBP4, retinol (SR), RBP4-to-SR molar ratio, dietary VA intakes normal-weight children investigate relationship these variables IR,...
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Machines that can learn and correct themselves already perform better than doctors at some tasks, says <b>Jörg Goldhahn</b>, but <b>Vanessa Rampton</b> <b>Giatgen A Spinas</b> maintain machines will never be able to replicate the inter-relational quality of therapeutic nature doctor-patient relationship
OBJECTIVE To study the impact of physical activity on glycemic control and plasma lipids [HDL cholesterol (HDL-C), HDL-C subfractions, triglycerides, lipoprotein(a)], blood pressure, weight, abdominal fat to determine necessary short-term adaptations in diabetes management during intensive endurance training patients with IDDM. RESEARCH DESIGN AND METHODS Well-controlled subjects IDDM (n = 20; HbA1c 7.6%) engaged a regular exercise program over period 3 months involving sports such as...
Increasing evidence indicates that a progressive decrease in the functional β-cell mass is hallmark of both type 1 and 2 diabetes. The underlying causes, apoptosis impaired secretory function, seem to be partly mediated by macrophage production interleukin (IL)-1β and/or high-glucose-induced IL-1β. Treatment diabetic patients with potassium channel opener diazoxide partially restores insulin secretion. Therefore, we studied effect novel NN414, selective for SUR1/Kir6.2, on glucose-...