A5086295953- Adipokines, Inflammation, and Metabolic Diseases
- Adipose Tissue and Metabolism
- Diet and metabolism studies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Regulation of Appetite and Obesity
- Pharmacology and Obesity Treatment
- Diabetes Treatment and Management
- Metabolism, Diabetes, and Cancer
- Obesity and Health Practices
- Cardiovascular Disease and Adiposity
- Obesity, Physical Activity, Diet
- Birth, Development, and Health
- Liver Disease Diagnosis and Treatment
- Diabetes Management and Research
- Bariatric Surgery and Outcomes
- Diabetes and associated disorders
- Pancreatic function and diabetes
- Hormonal Regulation and Hypertension
- Peroxisome Proliferator-Activated Receptors
- Hormonal and reproductive studies
- Diet, Metabolism, and Disease
- Lipoproteins and Cardiovascular Health
- Gestational Diabetes Research and Management
- Diabetes Management and Education
- Lipid metabolism and disorders
National Council Of Educational Research And Training
2025
University of Colorado Anschutz Medical Campus
2025
Sunrise University
2024
Mangalayatan University
2024
Mahatma Gandhi Central University
2024
Patliputra University
2024
Central University of South Bihar
2024
Banasthali University
2022-2024
National Research Centre on Equines
2022-2024
University of Warwick
2012-2023
Type 2 diabetes (T2DM) is associated with chronic low-grade inflammation. Adipose tissue (AT) may represent an important site of 3T3-L1 studies have demonstrated that lipopolysaccharide (LPS) activates toll-like receptors (TLRs) to cause For this study, we 1) examined activation TLRs and adipocytokines by LPS in human abdominal subcutaneous (AbdSc) adipocytes, 2) blockade NF-κB AbdSc 3) the innate immune pathway AT from lean, obese, T2DM subjects, 4) association circulating subjects. The...
Abstract Introduction Inflammation contributes to cardiovascular disease and is exacerbated with increased adiposity, particularly omental adiposity; however, the role of epicardial fat poorly understood. Methods For these studies expression inflammatory markers was assessed in biopsies from coronary artery bypass grafting (CABG) patients using quantitative RT-PCR. Further, effects chronic medications, including statins, as well peri-operative glucose, insulin potassium infusion, on gene...
For a given body mass index (BMI), mortality is higher in patients with central compared to generalized obesity. Glucocorticoids play an important role determining fat distribution, but circulating cortisol concentrations are reported be normal obese patients. Our recent studies show enhanced conversion of inactive cortisone (E) active (F) through the expression 11β-hydroxysteroid dehydrogenase type 1 (11βHSD1) cultured omental adipose stromal cells; autocrine production F may crucial factor...
Abstract Human serum paraoxonase is physically associated with HDL and has been implicated in the detoxification of organophosphates possibly prevention LDL lipid peroxidation. We investigated activity concentration 78 patients type 1 diabetes mellitus, 92 2 diabetes, 82 nondiabetic control subjects. Paraoxonase was generally lower diabetics than This decrease unrelated to differences phenotype distribution or its concentration. Rather, difference explained by specific activity, which...
Emerging data indicate that gut-derived endotoxin may contribute to low-grade systemic inflammation in insulin resistant states. This study aimed examine the importance of serum and inflammatory markers non-alcoholic fatty liver disease (NAFLD) patients, with without type 2 diabetes mellitus (T2DM), explore effect treatment a lipase inhibitor, Orlistat, on their status.Fasted from 155 patients biopsy proven NAFLD 23 control subjects were analysed for endotoxin, soluble CD14 (sCD14), tumour...
The prevalence of peripheral neuropathy, vascular disease, and foot ulceration in Type 2 diabetic patients the community were determined a community‐based study. Eight hundred eleven subjects (404 male, 407 female, mean age 65.4 (range 34–90) years, diabetes duration 7.4 (0–50) years) from 37 general practices three UK cities studied. Neuropathy was diagnosed clinically using modified neuropathy disability scores which ascertained structured interviews clinical examinations by one observer...
Resistin, a novel signalling molecule isolated in mice has been suggested to be the putative hormone thought link obesity with type 2 diabetes. The aim of this study was examine resistin protein expression human adipose tissue depots and secretion cells, characterize tissue. Both mRNA were analysed from (n = 5 samples: abdominal subcutaneous (Sc) n 19, omental (Om) 10, thigh 9, breast 7). Resistin levels similar both Sc Om depots, fat increased compared (p < 0.001) 0.001). These findings...
Abstract Resistin, an adipocyte secreted factor, has been suggested to link obesity with type 2 diabetes in rodent models, but its relevance human remains uncertain. Although previous studies have a role for this adipocytokine as pathogenic functional effects, regulation by insulin, and alteration of serum resistin concentration status remain be elucidated. Therefore, the aims study were analyze concentrations diabetic subjects; determine vitro effects insulin rosiglitazone (RSG) on...
Glucocorticoids play an important role in determining adipose tissue distribution and function, with glucocorticoid excess states such as Cushing's syndrome resulting central obesity. We have investigated the functional significance of local generation cortisol within from inactive cortisone through activity NADP(H)-dependent enzyme, 11beta-hydroxysteroid dehydrogenase type 1 (11betaHSD1). In primary cultures paired omental (om) sc human stromal cells (ASC; n = 34), 11betaHSD1 oxo-reductase...
<b>Objective: </b> To develop a grading scale to predict the risk of intracerebral hemorrhage (ICH) and prognosis after treatment with IV tissue-plasminogen activator (t-PA) in patients ischemic stroke. <b>Methods: We constructed five-point based on NIH Stroke Scale score, extent hypodensity CT scan, serum glucose at baseline, history diabetes thrombolysis (HAT score). evaluated predictive ability this scale, using c-statistics, two independent cohorts: t-PA treated group National Institute...
To evaluate the changes in circulating endotoxin after a high-saturated fat meal to determine whether these effects depend on metabolic disease state.Subjects (n = 54) were given high-fat (75 g fat, 5 carbohydrate, 6 protein) an overnight fast (nonobese control [NOC]: age 39.9 ± 11.8 years [mean SD], BMI 24.9 3.2 kg/m(2), n 9; obese: 43.8 9.5 years, 33.3 2.5 15; impaired glucose tolerance [IGT]: 41.7 11.3 32.0 4.5 12; type 2 diabetic: 45.4 10.1 30.3 18). Blood was collected before (0 h) and...
The adipokine leptin has critical importance in central appetite regulation. In contrast to some suggestion of adiponectin influencing energy homeostasis rodents, there is no evidence for or resistin entering the human blood-brain barrier.The objective was establish presence cerebrospinal fluid (CSF) and compare their distribution with leptin. Furthermore, we wished examine expression receptors 1 2 (AdipR1, AdipR2) hypothalamus.For this purpose, serum CSF samples were collected from 20 men...