A5064447648- Pancreatic function and diabetes
- Diabetes and associated disorders
- Diabetes Management and Research
- Diabetes Treatment and Management
- Diet and metabolism studies
- Cardiac, Anesthesia and Surgical Outcomes
- Diet, Metabolism, and Disease
- Hormonal and reproductive studies
- Adipose Tissue and Metabolism
- Metabolism, Diabetes, and Cancer
- Sperm and Testicular Function
- Sexual Differentiation and Disorders
- Advanced Glycation End Products research
- Endoplasmic Reticulum Stress and Disease
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Cannabis and Cannabinoid Research
- Congenital heart defects research
- Pluripotent Stem Cells Research
- Male Breast Health Studies
- Redox biology and oxidative stress
- Urinary Bladder and Prostate Research
- Enhanced Recovery After Surgery
- Xenotransplantation and immune response
- Sexual function and dysfunction studies
- COVID-19 Impact on Reproduction
Justus-Liebig-Universität Gießen
2015-2024
Universidade Federal do Rio Grande do Sul
2024
Universitätsklinikum Gießen und Marburg
2006-2023
Institut de Virologie
2021
University of Birmingham
2020
Third Way
2011-2018
Weatherford College
2009
Giessen School of Theology
2006
Statistisches Bundesamt
2002
Western University
1997
Exendin-4 purified from Heloderma suspectum venom shows structural relationship to the important incretin hormone glucagon-like peptide 1-(7-36)-amide (GLP-1). We demonstrate that exendin-4 and truncated exendin-(9-39)-amide specifically interact with GLP-1 receptor on insulinoma-derived cells lung membranes. displaced 125I-GLP-1, unlabeled 125I-exendin-4 binding site at rat RINm5F cells. had, like GLP-1, a pronounced effect intracellular cAMP generation, which was reduced by...
The pattern recognition receptor, RAGE (receptor for advanced glycation endproducts), propagates cellular dysfunction in several inflammatory disorders and diabetes. Here we show that functions as an endothelial adhesion receptor promoting leukocyte recruitment. In animal model of thioglycollate-induced acute peritonitis, recruitment was significantly impaired RAGE-deficient mice opposed to wild-type mice. diabetic observed enhanced the inflamed peritoneum compared with nondiabetic mice;...
Background. Blood flow is impaired in islet transplants, but there conflicting evidence on improving the outcome by promoting vascularization. We previously reported that endothelial cells (EC) possess significant angiogenic capacity. Methods. To further address this issue, we studied human islets culture under hypoxic conditions. Moreover, used a transgene mouse model with vascular growth factor (VEGF) production β-cells control of rat insulin promoter (RIP) to stimulate EC proliferation....
To evaluate the ability of ladarixin (LDX, 400 mg twice-daily for three cycles 14 days on/14 off), an inhibitor CXCR1/2 chemokine receptors, to maintain C-peptide production in adult patients with newly diagnosed type 1 diabetes.A double-blind, randomized (2:1), placebo-controlled study was conducted 45 males and 31 females (aged 18-46 years) within 100 first insulin administration. The primary endpoint area under curve (AUC) response a 2-hour mixed meal tolerance test (AUC[0-120 min] ) at...
Transplantation of pancreatic islets reconstitutes glucose homeostasis in diabetes mellitus. Before transplantation, are disrupted from the surrounding blood vessels by isolation procedure, with grafted tissue being subject to ischemic damage. The survival transplanted is assumed depend on effective revascularization. Perfusion studies suggest that newly formed microvessels supplying graft nutrients exclusively rebuilt host. It generally not known whether isolated contain endothelial cells...
The binding of the Ca 2+ ‐channel blocker d‐ cis ‐[ 3 H]diltiazem to guinea pig skeletal muscle microsomes is temperature‐dependent. At 2°C K D 39 nM and B max 11 pmol/mg protein. fully reversible ( −1 = 0.02 min ). sites discriminate between diastereoisomers 1‐ ‐diltiazem, recognize verapamil, gallopamil tiapamil, are sensitive La 3+ ‐inhibition. 30°C 37 2.9 D‐ ‐diltiazem‐labelling regulated by 1,4‐dihydropyridine blockers a novel activator in temperature‐dependent manner. an enhancement...
OBJECTIVE To evaluate safety and efficacy of DiaPep277 in preserving β-cell function type 1 diabetic patients. RESEARCH DESIGN AND METHODS DIA-AID is a multinational, phase 3, balanced-randomized, double-blind, placebo-controlled, parallel-group clinical study. Newly diagnosed patients (N = 457, aged 16–45 years) were randomized to subcutaneous injections or placebo quarterly for 2 years. The primary end point was the change from baseline area under glucagon-stimulated C-peptide curve....
Summary Given the increasing prevalence of metabolic syndrome (MetS) in males reproductive age, objective this prospective case–controlled study was to investigate impact subacute systemic inflammation associated with MetS on seminal cytokines and standard sperm parameters comparison healthy men. Between 2011 2014, we recruited 27 patients out 41 obese screened from an internal outpatient clinic. Twenty‐seven age‐matched controls were enrolled 54 men requesting vasectomy a urological A...
Abstract Diabetes-induced hyperglycemia has previously been shown to impact on male sub-/infertility, however, still little is known about the underlying mechanisms. In present study we have addressed three major biochemical pathways implicated in pathogenesis of induced organ damage (the advanced glycation end product (AGE) formation pathway, diacylglycerol-protein kinase C pathway (PKC), and polyol pathway) both testis epididymis Ins2 Akita mouse model Type 1 diabetes (T1DM). Hyperglycemia...
Adult-onset insulin dependent diabetes mellitus (IDDM) is associated with significant residual secretion. The process leading to the ultimate destruction of B cells may be influenced, among other factors, by quality and amount ingested protein. Using a standardized food questionnaire, we matched 13 individuals normal protein (NP; 0.74 +/- 0.08 g/kg.day) high (HP; 1.87 0.26 intake from sample 117 newly diagnosed IDDM patients according sex, age, body mass index, energy intake. Nondiabetic...
Oxidative stress produced during pancreatic islet isolation leads to significant β-cell damage. Homeostatic cytokines secreted subsequently transplantation damage β-cells by generating oxygen free radicals. In this study, exendin-4, a glucagon-like peptide-1 analog improved outcome increasing the survival of diabetic recipient mice from 58% 100%. We hypothesized that beneficial effect was due ability exendin-4 reduce oxidative stress. Further experiments showed it significantly reduced...