A5034341324- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- Nanoparticle-Based Drug Delivery
- Advanced Cellulose Research Studies
- Virus-based gene therapy research
- Advanced Drug Delivery Systems
- Polysaccharides and Plant Cell Walls
- biodegradable polymer synthesis and properties
- DNA and Nucleic Acid Chemistry
- Polymer Surface Interaction Studies
- Dendrimers and Hyperbranched Polymers
- Biosimilars and Bioanalytical Methods
- Advanced Polymer Synthesis and Characterization
- Additive Manufacturing and 3D Printing Technologies
- Graphene and Nanomaterials Applications
- Characterization and Applications of Magnetic Nanoparticles
- Drug Solubulity and Delivery Systems
- Wound Healing and Treatments
- Cell Adhesion Molecules Research
- Nanoparticles: synthesis and applications
- Blood properties and coagulation
- 3D Printing in Biomedical Research
- Pharmaceutical studies and practices
- Antimicrobial agents and applications
- Viral Infectious Diseases and Gene Expression in Insects
Friedrich Schiller University Jena
2015-2025
Friedrich-Alexander-Universität Erlangen-Nürnberg
2020-2025
Pharmaceutical Biotechnology (Czechia)
2021
University of Mannheim
2020
Schott (Germany)
2009-2019
GTx (United States)
2017
Antisense Therapeutics (Australia)
2008
Philipps University of Marburg
1998-2007
Texas Tech University Health Sciences Center
2004-2007
Texas Tech University
2004-2007
For two series of polyethylenimine-graft-poly(ethylene glycol) (PEI-g-PEG) block copolymers, the influence copolymer structure on DNA complexation was investigated and physicochemical properties these complexes were compared with results blood compatibility, cytotoxicity, transfection activity assays. In first series, PEI (25 kDa) grafted to different degrees substitution PEG (5 in second molecular weight (MW) varied (550 Da 20 kDa). Using atomic force microscopy, we found that strongly...
Limitations of PEG in drug delivery have been reported from clinical trials. PEtOx (0.4-40 kDa) as alternative is synthesized by a living, microwave-assisted polymerization, and directly compared to similar molar mass regarding cytotoxicity hemocompatibility. In short-term treatments, both types polymers are well tolerated even at high concentrations. Moderate concentration dependent cytotoxic effects occurred only after long-term incubation concentrations higher than therapeutic doses....
Two series of block copolymers were prepared by grafting linear poly(ethylene glycol) (PEG) onto branched polyethylenimine (PEI). In the first series, PEI (25 000) was grafted with varied numbers PEG blocks (5000). The second composed all containing an equal amount (50%) and (50%), but different molecular weights (MW: 550−20 000). a two-step synthesis, both activation monomethyl-PEGs coupling reactions PEGs performed hexamethylene diisocyanate (HMDI), leading to water-soluble hydrolytically...
Abstract Advances in biotechnology, proteomics, and genomics, as well the deeper understanding of molecular cellular bases pathophysiological states, have allowed development novel drugs such proteins, peptides, nucleic acids therapeutic strategies future. Their application, however, requires sophisticated drug delivery systems which can be used to alter pharmacokinetics release characteristics drugs, increase tissue specificity biocompatibility. In this context, polymers provide most...
Abstract Im stetig wachsenden Feld der Polymer‐basierten Wirkstoff‐Transport‐Systeme gilt Poly(ethylenglycol) (PEG) als Goldstandard für Stealth‐Polymere. Welche Eigenschaften PEG aufweist, die diese herausragende Stellung rechtfertigen, soll in diesem Aufsatz diskutiert werden. Die ersten PEGylierten Produkte erschienen bereits vor 20 Jahren auf dem Markt. Seither konnten viele Erkenntnisse klinischen Untersuchungen gewonnen werden, allerdings wurden dabei nicht nur Vorteile festgestellt,...
Abstract The synthesis of linear polyethyleneimine (LPEI) by acidic hydrolysis poly(2‐ethyl‐2‐oxazoline) is studied and optimized to reach the highest degree within shortest time range using a microwave synthesizer. In addition, purification procedure significantly improved; fast batch processing combined with an excellent control actual heating represents well‐suited alternative conventional on way “pharmagrade” PEI. developed protocol for preparation methyl proton‐initiated LPEIs shows...