Miguel Gama

ORCID: 0000-0002-5655-0015
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Research Areas
  • Advanced Cellulose Research Studies
  • Biofuel production and bioconversion
  • Electrospun Nanofibers in Biomedical Applications
  • Enzyme Production and Characterization
  • Polysaccharides and Plant Cell Walls
  • Nanoparticle-Based Drug Delivery
  • biodegradable polymer synthesis and properties
  • Nanocomposite Films for Food Packaging
  • Antimicrobial Peptides and Activities
  • Hydrogels: synthesis, properties, applications
  • Advanced Drug Delivery Systems
  • Polysaccharides Composition and Applications
  • Bone Tissue Engineering Materials
  • 3D Printing in Biomedical Research
  • Tissue Engineering and Regenerative Medicine
  • RNA Interference and Gene Delivery
  • Enzyme Catalysis and Immobilization
  • Graphene and Nanomaterials Applications
  • Polymer Surface Interaction Studies
  • Nanoparticles: synthesis and applications
  • Lignin and Wood Chemistry
  • Material Properties and Processing
  • Food composition and properties
  • Wound Healing and Treatments
  • Proteins in Food Systems

University of Minho
2016-2025

Instituto Politécnico de Lisboa
2023

Universidade Federal de Santa Maria
2020

Instituto Biológico
2020

Clinical Academic Center of Braga
2020

Institute for Biotechnology and Bioengineering
2010-2019

Jaguar Land Rover (United Kingdom)
2014-2016

University of Sheffield
2005-2010

Centre de Recherche en Automatique de Nancy
2006

Centre National de la Recherche Scientifique
2006

Bacterial cellulose (BC) is a polymer with interesting physical properties owing to the regular and uniform structure of its nanofibers, which are formed by amorphous (disordered) crystalline (ordered) regions. Through hydrolysis strong acids, it possible transform BC into stable suspension nanocrystals, adding new functionality material. The aim this work was evaluate effects inorganic acids on production nanocrystals (BCNCs). Acid performed using different H2SO4 concentrations reaction...

10.1016/j.carbpol.2016.08.090 article EN publisher-specific-oa Carbohydrate Polymers 2016-09-03

The fabrication of ultrathin films that are electrically conductive and mechanically strong for electromagnetic interference (EMI) shielding applications is challenging. Herein, ultrathin, strong, highly flexible Ti3C2Tx MXene/bacterial cellulose (BC) composite fabricated by a scalable in situ biosynthesis method. MXene nanosheets uniformly dispersed the three-dimensional BC network to form entangled structure endows MXene/BC with excellent mechanical properties (tensile strength 297.5 MPa...

10.1021/acsnano.0c10666 article EN ACS Nano 2021-05-06

Hydrogel nanoparticles—also referred to as polymeric nanogels or macromolecular micelles—are emerging promising drug carriers for therapeutic applications. These nanostructures hold versatility and properties suitable the delivery of bioactive molecules, namely biopharmaceuticals. This article reviews latest developments in use self-assembled applications, including small molecular weight drugs, proteins, peptides, oligosaccharides, vaccines nucleic acids. The materials techniques used...

10.3390/ma3021420 article EN Materials 2010-02-24

This work reports on the influence of polarization and morphology electroactive poly(vinylidene fluoride), PVDF, adhesion myoblast cells. Non-poled, "poled+" "poled−" β-PVDF films were prepared by solvent casting followed corona poling. Furthermore, random aligned electrospun fiber mats also prepared. It is demonstrated that negatively charged surfaces improve cell proliferation directional growth cells can be achieved culturing fibers. Therefore, potential application materials for muscle...

10.1039/c3ra43499k article EN RSC Advances 2013-01-01

Abstract Background Cellulose Binding Domains (CBD) were conjugated with fluorescein isothiocyanate (FITC). The surface concentration of the adsorbed on cellulose fibres was determined by fluorescence image analysis. Results For a CBD-FITC 60 mg/L, coating fraction 78% and 110% estimated for Portucel Whatman fibres, respectively. saturating CBD concentration, using CF11 25.2 × 10 -13 mol/mm 2 estimated, equivalent to 4 protein monolayers. This result does not imply existence several layers....

10.1186/1472-6750-8-1 article EN cc-by BMC Biotechnology 2008-01-09

Abstract The bacterial cellulose (BC) secreted by Gluconacetobacter xylinus is a network of pure nanofibres which has high crystallinity, wettability and mechanical strength. These characteristics make BC an excellent material for tissue-engineering constructs, noteworthy artificial vascular grafts. In this work, the in vivo biocompatibility membranes produced two G. strains was analyzed through histological analysis long-term subcutaneous implants mice. caused mild benign inflammatory...

10.1163/092050611x581516 article EN Journal of Biomaterials Science Polymer Edition 2012-05-08

This work reports on the influence of polarization electroactive poly(vinylidene fluoride), PVDF, biological response cells cultivated under static and dynamic conditions. Non-poled "poled +" β-PVDF with without a titanium layer were thus prepared. A thin was deposited PVDF films in order to obtain more homogeneous surface charge. The MC3T3-E1 osteoblast cell culture exhibited different responses presence films. positively charged promote higher adhesion proliferation, which is conditions...

10.1039/c2ra21841k article EN RSC Advances 2012-01-01

Among the strategies to improve a material's hemocompatibility, pre-coating with tripeptide Arg-Gly-Asp (RGD) is used favor endothelialization thus lowering thrombogenicity. The blood compatibility of native and RGD-modified bacterial cellulose (BC) was studied in this work for first time. plasma recalcification time whole clotting results demonstrate hemocompatibility BC. A significant amount protein adsorb BC fibres, however, according analysis by intrinsic tryptophan fluorescence...

10.1002/jbm.a.33148 article EN Journal of Biomedical Materials Research Part A 2011-06-16
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