A5033182136- Thyroid Cancer Diagnosis and Treatment
- Hormonal and reproductive studies
- Vitamin D Research Studies
- Thyroid Disorders and Treatments
- Thyroid and Parathyroid Surgery
- Parathyroid Disorders and Treatments
- Diabetes and associated disorders
- Estrogen and related hormone effects
- Sexual Differentiation and Disorders
- Bone health and osteoporosis research
- Bone health and treatments
- Neuroendocrine Tumor Research Advances
- Genetic Syndromes and Imprinting
- Digestive system and related health
- Stress Responses and Cortisol
- Prostate Cancer Treatment and Research
- Medical and Biological Sciences
- Global Cancer Incidence and Screening
- Medical Imaging and Pathology Studies
- Vitamin C and Antioxidants Research
- Adrenal Hormones and Disorders
- Renal cell carcinoma treatment
- Congenital heart defects research
- Growth Hormone and Insulin-like Growth Factors
- T-cell and B-cell Immunology
KU Leuven
2016-2025
Universitair Ziekenhuis Leuven
2000-2018
AZ Sint-Jan
2012
Institute of Experimental Endocrinology of the Slovak Academy of Sciences
2006
Background: Low serum 25-hydroxyvitamin D (25-[OH]D) levels have been associated with lower FEV1, impaired immunologic control, and increased airway inflammation. Because many patients chronic obstructive pulmonary disease (COPD) vitamin deficiency, effects of supplementation may extend beyond preventing osteoporosis. Objective: To explore whether high doses could reduce the incidence COPD exacerbations. Design: Randomized, single-center, double-blind, placebo-controlled trial....
This European expert consensus statement provides recommendations for the diagnosis and management of primary hyperparathyroidism (PHPT), chronic hypoparathyroidism in adults (HypoPT), parathyroid disorders relation to pregnancy lactation. Specified areas interest unmet needs identified by experts at second ESE Educational Program Parathyroid Disorders (PARAT) 2019, were discussed during two virtual workshops 2021, subsequently developed working groups with specified areas. PHPT is a common...
Immune checkpoint inhibitors (ICI) have revolutionized cancer treatment but are associated with significant autoimmune endocrinopathies that pose both diagnostic and challenges. The aim of this guideline is to provide clinicians the best possible evidence-based recommendations for follow-up patients ICI-induced endocrine side-effects based on Grading Recommendations Assessment, Development, Evaluation system. As these drugs been used a relatively short time, large systematic investigations...
SUMMARY Receptors for 1,25(OH)2vitaminD3 are found in most immune cells and important immunological effects have been described vitro, reflected by its capacity to prevent autoimmunity prolong graft survival. The aim of this study was examine the presence nature enzyme responsible final activation molecule, 1-α-hydroxylase, murine macrophages analyse regulation possible role system. Peritoneal from C57Bl/6 mice were incubated with lipopolysaccharide (LPS; 100 μg/ml), interferon-gamma (IFN-γ;...
Sunitinib is approved for the treatment of metastatic renal cell carcinoma (RCC) and imatinib-resistant or -intolerant gastrointestinal stromal tumours (GIST). Several studies have identified unexpected rates thyroid dysfunction with sunitinib treatment. We performed a prospective observational study aim more accurately defining incidence severity hypothyroidism in RCC GIST patients receiving sunitinib. Thyroid function was assessed at baseline on days 1 28 each cycle. antibodies were during...
During aging, total testosterone (TT) declines and SHBG increases, resulting in a greater decrease calculated free T (cFT). Currently, guidelines suggest using TT to diagnose androgen deficiency reserve cFT only for men with borderline TT.Our objective was investigate if either low or is more strongly associated androgen-related clinical endpoints.A of 3334 community-dwelling men, aged 40-79 years, were included this study. Differences variables between the referent group both normal (≥10.5...
Abstract Sex hormone-binding globulin (SHBG) is the high-affinity binding protein for androgens and estrogens. According to free hormone hypothesis, SHBG modulates bioactivity of sex steroids by limiting their diffusion into target tissues. Still, in vivo physiological role circulating remains unclear, especially since mice rats lack post-natally. To test hypothesis , we examined total steroid concentrations on organs expressing a human transgene. increased androgen estrogen via...
Low testosterone (T) has been associated with incident metabolic syndrome (MetS), but it remains unclear if this association is independent of sex hormone binding globulin (SHBG). Estradiol (E2) may also be MetS, few studies have investigated this.To study the between baseline steroids and development MetS to investigate influence SHBG, body mass index (BMI) insulin resistance on risk.Three thousand three hundred sixty nine community-dwelling men aged 40-79 years were recruited for...
Androgen deficiency is associated with obesity, metabolic syndrome, and type 2 diabetes mellitus in men, but the mechanisms behind these associations remain unclear. In this study, we investigated combined effects of androgen high-fat diet (HFD) on body composition glucose homeostasis C57BL/6J male mice. Two models were used: orchidectomy (ORX) receptor knockout Both displayed higher adiposity serum leptin levels upon HFD, whereas no differences seen a regular diet. Fat accumulation HFD ORX...
Abstract Objectives To compare clinical laboratory workflows for the assessment of androgens in men, focusing on total testosterone (T), sex hormone-binding globulin (SHBG) and free T, laboratories throughout Europe. Methods An internet-based survey that included questions related to pre-analytical, analytical post-analytical phases androgen measurements was distributed between December 2022 2023 by laboratory/chemistry endocrine societies. A 124 unique records from 27 European countries...
Prevention of type 1 diabetes in NOD mice by 1,25-dihydroxyvitamin D3 [1alpha,25(OH)2D3] is accompanied a T-helper (Th) 1/Th2 cytokine shift the pancreas. The aim this study was to investigate whether immune also occurs outside pancreas and it limited autoantigen-specific responses. treated with 1alpha,25(OH)2D3 (5 microg/kg every 2 days) or control vehicle were immunized GAD65 (p524-543) ovalbumin (OVA) rear footpads. First, we examined T-cell proliferation production (via enzyme-linked...
Abstract Immune cells carry receptors for 1,25-dihydroxyvitamin D3 [1,25(OH)2D3; vitamin D receptor (VDR)] and individuals with severe deficiency have immune abnormalities. The aim of this study was to investigate the role in system by studying VDR-knockout (VDR-KO) mice. VDR-KO mice had same metabolic phenotype as rachitic animals hypocalcemia. Leukocytosis, lymphocyte subset composition different organs, splenocyte proliferation several stimuli were normal, except a lower response anti-CD3...
Abstract BACKGROUND The IFCC Committee for Standardization of Thyroid Function Tests developed a global harmonization approach thyroid-stimulating hormone measurements. It is based on multiassay method comparison study with clinical serum samples and target setting robust factor analysis method. Here we describe the Phase IV reference interval (RI) studies conducted objective to recalibrate participating assays demonstrate proof-of-concept. METHODS Fourteen manufacturers measured RI panel; 4...
The prevalence and clinical relevance of thyroid stimulating hormone (TSH) receptor (TSHR) blocking antibodies (TBAb) in patients with autoimmune disease (AITD) was investigated. Serum TBAb were measured a reporter gene bioassay using Chinese hamster ovary cells. Blocking activity defined as percentage inhibition luciferase expression relative to induction bovine TSH alone (cut-off 40% inhibition). All samples for TSHR stimulatory antibody (TSAb) binding inhibiting immunoglobulins (TBII). A...
The measurement of TSH receptor (TSHR) antibodies is warranted for diagnosis Graves' disease (GD).The performance, detection sensitivity, and specificity 6 TSHR immunoassays were compared.Two bioassays 4 binding assays (Kronus, Immulite, Kryptor, Dynex) compared in a dilution study performed patients with autoimmune thyroid disease. Both to 2 using stimulatory (M22) blocking (K1-70) monoclonal antibody (MAb) mixtures.Thirty samples from (TSAb)-positive/blocking (TBAb)-negative GD diluted...
Pseudohypoparathyroidism (PHP) is caused by (epi)genetic defects in the imprinted GNAS cluster. Current classification of PHP patients hampered clinical and molecular diagnostic overlaps. The European Consortium for study designed a genome-wide methylation to improve diagnosis. HumanMethylation 450K BeadChip was used analyze 24 with parathyroid hormone resistance 20 age- gender-matched controls. Patients were previously diagnosed GNAS-specific differentially methylated regions (DMRs) include...
Abstract Low testosterone (T) in men, especially its free fraction, has been associated with loss of energy. In accordance, orchidectomy (ORX) rodents results decreased physical activity. Still, the mechanisms through which T stimulates activity remain mostly obscure. Here, we studied voluntary wheel running behavior three different mouse models androgen deficiency: ORX, receptor (AR) knock-out (ARKO) and sex hormone binding globulin (SHBG)-transgenic mice, a novel model “low T”. Our clearly...