A5015947439- Thyroid Disorders and Treatments
- Growth Hormone and Insulin-like Growth Factors
- Regulation of Appetite and Obesity
- Pituitary Gland Disorders and Treatments
- Thyroid Cancer Diagnosis and Treatment
- Biochemical Analysis and Sensing Techniques
- Neuroendocrine Tumor Research Advances
- Adipokines, Inflammation, and Metabolic Diseases
- Childhood Cancer Survivors' Quality of Life
- Hormonal and reproductive studies
- Adipose Tissue and Metabolism
- Electrolyte and hormonal disorders
- Diet and metabolism studies
- Adrenal Hormones and Disorders
- Cancer, Hypoxia, and Metabolism
- Neuroblastoma Research and Treatments
- Stress Responses and Cortisol
- Wnt/β-catenin signaling in development and cancer
- Ovarian function and disorders
- Adrenal and Paraganglionic Tumors
- Hormonal Regulation and Hypertension
- Metabolism, Diabetes, and Cancer
- Liver Disease Diagnosis and Treatment
- Hypothalamic control of reproductive hormones
- Sexual Differentiation and Disorders
University of Lübeck
2014-2024
University of Manchester
2007-2022
The Christie Hospital
2007-2021
Manchester Academic Health Science Centre
2010-2021
The Christie NHS Foundation Trust
2010-2021
University Hospital Schleswig-Holstein
2010-2020
Medizinische Hochschule Hannover
2000-2015
Universitäres Kinderwunschzentrum Lübeck
2014
Endocrinology Research Center
2012
In-Q-Tel
2011
Subclinical hypothyroidism (SCH) should be considered in two categories according to the elevation serum thyroid-stimulating hormone (TSH) level: mildly increased TSH levels (4.0-10.0 mU/l) and more severely value (>10 mU/l). An initially raised TSH, with FT4 within reference range, investigated a repeat measurement of both FT4, along thyroid peroxidase antibodies, preferably after 2- 3-month interval. Even absence symptoms, replacement therapy L-thyroxine is recommended for younger patients...
Objectives: To evaluate metabolic abnormalities, beta-cell function, lipid profile and vascular risk factors in HIV patients on protease inhibitors (PI). Design: Prospective cross-sectional study. Methods: Thirty-eight HIV-1-infected receiving at least one PI were compared with 17 PI-naive an oral glucose tolerance test (OGTT). Serum glucose, insulin, proinsulin, C-peptide determined. The fasting pattern was analysed using electrophoresis the assessment of apolipoproteins including...
Growth-differentiation factor-15 (GDF-15) is a member of the transforming growth factor-beta cytokine superfamily that induced in heart after ischemia-and-reperfusion injury. Circulating levels GDF-15 may provide prognostic information patients with non-ST-elevation acute coronary syndrome.Blood samples were obtained on admission from 2081 chest pain and either ST-segment depression or troponin elevation who included Global Utilization Strategies to Open Occluded Arteries (GUSTO)-IV...
The indirect water-deprivation test is the current reference standard for diagnosis of diabetes insipidus. However, it technically cumbersome to administer, and results are often inaccurate. study compared with direct detection plasma copeptin, a precursor-derived surrogate arginine vasopressin.
Central hypothyroidism (CeH) is a rare form of characterized by insufficient thyroid stimulation due to disturbed pituitary and/or hypothalamic functioning. Due its origin and the whole clinical context, CeH represents challenging condition in practice as it suboptimal accuracy biochemical parameters for diagnosis management. Since no expert consensus or guidance this currently available, task force experts received commitment from European Thyroid Association (ETA) prepare document based on...
<i>Background:</i> Analysis of insulin-like growth factor I in serum (S-IGF-I) is an integral component the diagnosis GH-related disorders and going to be interest follow-up many disorders. The objective present study was develop cross-sectional reference values for S-IGF-I measured by automated chemiluminescence immunoassay (Nichols Advantage<sup>®</sup>). <i>Methods:</i> included samples from 3,961 healthy subjects (2,201 males, 1,760 females) aged 1...
The circadian and pulsatile TSH secretion profiles were investigated in 5 females at the time of menstruation 21 healthy males by sampling blood every 10 min for 24 h. Computer-assisted analysis, i.e. Cluster Desade programs, revealed means 9.9 ± 1.7 (Cluster) 11.4 3.9 (Desade) pulses/24 More than 50% pulses detected between 2000–0400 Male female subjects showed no significant difference basal mean or response to TRH (200 μg). Repetition analysis 4 after 1, 2, 6 months (2 subjects) a...
Growth-differentiation factor 15 (GDF15) is a member of the transforming growth beta (TGF-beta) cytokine superfamily. There has been increasing interest in using circulating GDF15 as biomarker patients, for example those with cardiovascular disease.We developed an IRMA that uses polyclonal, affinity chromatography-purified goat antihuman IgG antibody, assessed preanalytic characteristics GDF15, and determined concentrations 429 apparently healthy elderly individuals 153 patients chronic...
Insulin resistance is a hallmark of type 2 diabetes, and many insights into the functions insulin have been gained through study mice lacking IR. To gain better understanding role action in brain versus peripheral tissues, we created mouse models with inducible IR inactivation, 1 all tissues including (IRDeltawb), restricted to (IRDeltaper). While downregulation expression resulted severe hyperinsulinemia both models, hyperglycemia was more pronounced IRDeltawb mice. Both strains displayed...
The age-dependent decline of the gonadal and somatotopic axis has been causally linked to frailty in elderly by their effects on muscle mass bone mineral density. However, for healthy men data serum oestrogens androgens, as well IGF-1, a common outcome measure covering whole adult age range are scarce. We therefore studied healthy, nonobese male subjects between 20 80 years asses morning concentrations total (T), free (FT), bioavailable testosterone (bT), oestradiol (E2), (bE2), oestrone...
<h3>BACKGROUND</h3> Leptin is an important regulator of food intake and energy expenditure. Initially it was thought to be expressed exclusively in secreted by adipocytes. Recently, leptin expression also noted other tissues, including rat gastric mucosa. Information on receptor the human stomach lacking. <h3>AIM</h3> To investigate its corresponding receptors epithelial cells. <h3>METHODS</h3> Fundic antral mucosal biopsies, primary cultures cells, cancer cell line AGS were screened for...
Ageing is associated with progressive endothelial dysfunction in normal humans. Flow-mediated dilation (FMD) of the brachial artery impaired elderly individuals cardiovascular disease and vascular nitric oxide (NO) bioavailability reduced. We investigated whether oral L-arginine, substrate for NO synthesis, can improve FMD healthy very old people. In a prospective, double-blind, randomized crossover trial, 12 subjects (age 73.8 6 2.7 years) took L-arginine (8 g p.o. two times daily) or...
The syndrome of polycystic ovaries (PCOS) is a known risk factor for type 2 diabetes. It not known, however, whether the increase in diabetes related to endocrine abnormalities associated with PCOS such as hyperandrogenemia, or it consequence anthropometric metabolic alterations frequently observed women.Since markers inflammation are supposed predict diabetes, interleukin-6 (IL-6) and C-reactive protein (CRP) combination parameters obesity, insulin resistance hyperandrogenism were...
RIA-based sex hormone measurements offer only limited precision and specificity in the low concentration range of women. Therefore, we aimed to establish age-specific reference ranges for serum concentrations women using mass spectrometry quantile regression. Data from 985 aged 20–80 yr, recruited prospective Study Health Pomerania, were included analyses. Quantile regressions models performed calculate 2.5th 97.5th percentiles Serum total testosterone (TT) androstenedione (AD) measured by...
The inhibitory action of thyroid hormones (TH) and glucocorticoids on circadian pulsatile TSH secretion was investigated in groups five normal men by sampling blood every 10 min for 24 h (start, 1750 h). Serum measured a sensitive immunoradiometric assay. Continuous infusion 50 micrograms T3 or 250 T4 8 (1900-0300 h) significantly suppressed serum levels (T3, P less than 0.025; T4, 0.05; paired t test). Administration 3 g sodium ipodate 7 before TH did not alter the response to T3, but...
Polycystic ovary syndrome (PCOS) is a heterogeneous disease with many different aspects, including hyperandrogenism and metabolic disturbances. Clinical phenotypes show patterns of steroid hormones that have been investigated to some extent.This study intended determine the role testosterone (TT) dihydrotestosterone (DHT) ratio (TT/DHT ratio) in PCOS patients further assess correlation this hormonal, anthropometric, parameters.Serum samples 275 premenopausal fulfilling Rotterdam criteria 35...
Highlights•Thyroid hormone induces browning independent of sympathetic nervous system through TRβ•Despite high UCP1, the beige fat lacks adrenergic input and is inactive•Thyroid hormone's metabolic thermogenic effects are maintained in UCP1 knockout mice•Thyroid hyperthermia elevates body temperature setpointSummaryRegulation critically depends on thyroid (TH). Recent studies revealed that TH white adipose tissue, possibly contributing to observed hyperthyroid patients potentially providing...