A5025435200- Sarcoma Diagnosis and Treatment
- Vascular Tumors and Angiosarcomas
- CAR-T cell therapy research
- Cardiac tumors and thrombi
- Colorectal and Anal Carcinomas
- Management of metastatic bone disease
- Neuroblastoma Research and Treatments
- Hematological disorders and diagnostics
- Testicular diseases and treatments
- Surgical site infection prevention
- Pediatric Hepatobiliary Diseases and Treatments
- Nanoplatforms for cancer theranostics
- Traumatic Brain Injury and Neurovascular Disturbances
- Inflammatory Biomarkers in Disease Prognosis
- Ultrasound and Hyperthermia Applications
- Cancer Immunotherapy and Biomarkers
- Reconstructive Surgery and Microvascular Techniques
- Soft tissue tumor case studies
- Nutrition and Health in Aging
- Photodynamic Therapy Research Studies
- Electrospun Nanofibers in Biomedical Applications
- Head and Neck Cancer Studies
- Renal and related cancers
- Advanced Cellulose Research Studies
- Intestinal Malrotation and Obstruction Disorders
Deutschen Konsortium für Translationale Krebsforschung
2025
LMU Klinikum
2023-2025
Ludwig-Maximilians-Universität München
2021-2025
German Cancer Research Center
2025
Massachusetts General Hospital
2024
Harvard University
2024
Paracelsus Medizinische Privatuniversität
2020
Foundation for laboratory medicine
2003
University of Geneva
2003
Background: The prognosis of patients with advanced soft tissue sarcoma (STS) remains dismal. Trofosfamide (TRO) has been proposed as a well-tolerated oral maintenance therapy. This retrospective analysis aims to determine the value this Methods: Fifty-nine STS who received TRO therapy between 2016 and 2022 were reviewed analysed regarding clinical parameters outcomes. Results: median age was 48 years; most common histological subtype synovial (n = 22, 37%), 71% 42) presented metastatic...
Local ablative therapies (LAT) are increasingly used in patients with metastatic soft tissue sarcoma (STS), yet evidence-based standards lacking. This study aimed to assess the impact of LAT on survival STS and identify prognostic factors.
Abstract Lymph node metastasis (LNM) occurs in less than 5% of soft tissue sarcoma (STS) patients and indicates an aggressive course disease. Suspicious lymph nodes (LN) staging imaging are a frequent topic discussion multidisciplinary tumor boards. Predictive markers needed to facilitate stratification improve treatment STS patients. In this study, 56 with radiologically suspicious subsequently histologically examined LN were reviewed. Patients benign (n = 26) metastatic 30) analyzed regard...
The aim of this retrospective study is to evaluate for the first time impact a nanocellulose-based wound dressing in treatment pediatric patients with both partial- and deep-thickness burns. Usability effectiveness were defined based on parameters such as frequency changes under narcosis, duration hospital stay, onset complications, need additional treatments, follow up scar formation assessment. Fifty-six children who sustained burns year 2018 treated included trial. mean stay was 6.7 days....
ABSTRACT Background Dacarbazine is currently considered the better combination partner for doxorubicin compared to ifosfamide treatment of leiomyosarcoma (LMS). Regional hyperthermia (RHT) combined with neoadjuvant chemotherapy has been shown improve survival in patients locally advanced high‐risk STS. We sought evaluate role and dacarbazine (AD) versus (AI) RHT LMS. Methods Patients high‐grade LMS, including limited metastases, eligible first‐line either AI + or AD between 2014 2022 were...
Abstract Background The current understanding of the prognostic value routine pre-treatment laboratory parameters in patients with high-risk soft tissue sarcoma (HR-STS) is limited. We sought to analyze several inflammatory biomarkers a large cohort HR-STS undergoing neoadjuvant therapy followed by curative surgical resection. Methods 123 locally advanced undifferentiated pleomorphic (UPS), liposarcoma (LPS), leiomyosarcoma (LMS), and synovial (SS) who underwent preoperative chemotherapy...
Abstract Background The prognostic and predictive value of obesity sarcopenia remains poorly defined in patients with high-risk soft tissue sarcoma (HR-STS). We sought to correlate clinical outcomes CT-based body composition parameters HR-STS undergoing a multimodal preoperative therapy. impact radiologic histopathologic response treatment was correlated individual fat muscle distribution. Methods Patients locally advanced non-abdominal chemotherapy + regional hyperthermia (RHT) +/-...
Abstract We report a long-lasting response to the immune checkpoint inhibitor nivolumab in combination with regional hyperthermia (RHT) patient recurrent metastatic Head and Neck Squamous Cell Carcinoma (HNSCC) negative programmed death ligand 1 (PD-L1) expression. Treatment was well tolerated no local side effects. Tumor-related symptoms orbital masticator area gradually decreased under treatment RHT. Over course of treatment, magnetic resonance imaging (MRI) showed tumor control heated...
Abstract Purpose Epithelioid hemangioendothelioma (EHE) represents an ultra-rare, translocated vascular sarcoma with a heterogeneous course of disease. The optimal systemic treatment for patients advanced EHE remains unclear. We sought to evaluate the value pazopanib (PAZ) as first-line in metastatic EHE. Methods Thirteen and PAZ at our institution between 2012 und 2023 were reviewed analyzed regard clinical outcomes. Results At median follow-up 51.4 months, progression-free survival (PFS)...
The unfailing detection of micrometastases during surgery patients suffering from ovarian cancer is mandatory for the optimal management this disease. Thus, present study aimed at determining feasibility detecting in an model using intraperitoneal administration photosensitiser precursor hexaminolaevulinate (HAL). For purpose, HAL was applied intraperitoneally different concentrations (4–12 mM) to immunocompetent Fischer 344 rats bearing a syngeneic epithelial carcinoma. tumours were...
Due to poor outcomes and limited treatment options, patients with advanced bone soft tissue sarcomas (BS/STS) may undergo comprehensive molecular profiling of tumor samples identify possible therapeutic targets. The aim this study was determine the impact routine in setting a dedicated precision oncology program BS/STS German large-volume sarcoma center.92 who received genomic (CGP) were subsequently discussed our board (MTB) between 2016 2022 included. Patient records retrospectively...
(1) Background: Unruptured Intracranial Aneurysms (UIAs) are common blood vessel malformations, occurring in up to 3 % of healthy adults. Magnetic Resonance Angiography (MRA) is frequently used for the screening UIAs due its high resolution vascular anatomy. However, T2-Weighted Imaging (T2WI) a standard sequence utilized majority outpatient head scans. By employing such as T2WI, there possible shift towards early detection through opportunistic screening. Here, we assess Deep Learning...
Molecular predictors of response to chemotherapy and survival have not been put into clinical practice in high-risk soft tissue sarcomas (HR-STS) by now. The expression TOP2A SIRT1 has implications for the mechanism action doxorubicin, which is backbone HR-STS. Pre-treatment samples 167 patients with HR-STS were collected. Protein levels evaluated microarrays immunohistochemistry correlated clinicopathological parameters, including overall (OS). was seen 47% 60% HR-STS, respectively....
Surgical site infections (SSI) are one of the most common complications after extensive sarcoma resections and represent a daily challenge. SSI occur in up to 50% cases particularly peripelvic area. One possible approach reduce infection rate is perioperative antibiotic prophylaxis. The aim this study therefore was investigate influence prophylaxis on location-specific with ampicillin/sulbactam.
(1) Background: The expression of T cell immunoglobulin and mucin domain-containing protein 3 (TIM-3), an immune checkpoint receptor on cells, has been associated with dismal outcomes advanced tumor stages in various solid tumors. blockade TIM-3 is currently under examination several clinical trials. This study examines high-risk soft tissue sarcomas (HR-STS). (2) Methods: Tumor level was analyzed pre-treatment biopsies patients HR-STS. correlated clinicopathological parameters including...
Background: Local ablative therapies (LAT) are increasingly used in patients with metastatic soft tissue sarcoma (STS), yet evidence-based standards lacking. This study aimed to assess the impact of LAT on survival STS and identify prognostic factors.Methods: In this retrospective multicenter study, 246 disease who underwent tumor board recommendation between 2017 2021 were analyzed. A mixed effects model was applied evaluate multiple events per patient.Results: Median overall (OS) after...
<title>Abstract</title> <bold>Background: </bold>Surgical site infections (SSI) are one of the most common complications after extensive sarcoma resections and represent a daily challenge. SSI occur in up to 50% cases particularly peripelvic area. One possible approach reduce infection rate is perioperative antibiotic prophylaxis. The aim this study therefore was investigate influence prophylaxis on location-specific with ampicillin/sulbactam. <bold>Methods patients: </bold>This monocentric...
Was ist neu? Lokalisierte Stadien Die kurative Resektion +/– prä- oder postoperative Strahlentherapie die Therapiebasis im lokalisierten Stadium. Bei hohem Rezidivrisiko eine neoadjuvante anthrazyklinbasierte Kombinationstherapie, ggf. in Kombination mit regionaler Hyperthermie, zu erwägen. Metastasiertes Stadium Anthrazykline gelten auch metastasierten weiterhin als Standard für Erstlinientherapie. Anthrazyklinbasierte Kombinationen können je nach Subtyp und Remissionsdruck Betracht gezogen...
Abstract Introduction: Lymph node metastasis (LNM) occurs in less than 5% of soft tissue sarcoma (STS) patients and indicates an aggressive course disease. Suspicious lymph nodes staging imaging are a frequent matter discussion multidisciplinary tumor boards. Predictive markers needed to enable stratification improve treatment STS patients. Materials Methods In this study, 56 with radiologically suspicious subsequently histologically examined (LN) were reviewed. Patients benign (n = 26)...