A5063988665- Colorectal Cancer Surgical Treatments
- Hernia repair and management
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Treatments and Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Pelvic and Acetabular Injuries
- Appendicitis Diagnosis and Management
- Extracellular vesicles in disease
- Colorectal Cancer Screening and Detection
- RNA modifications and cancer
- Cancer-related gene regulation
- COVID-19 and healthcare impacts
- Colorectal and Anal Carcinomas
- Pancreatic and Hepatic Oncology Research
- Cancer-related molecular mechanisms research
- Intraperitoneal and Appendiceal Malignancies
- Genetic factors in colorectal cancer
- Adrenal and Paraganglionic Tumors
- Abdominal Surgery and Complications
- Ubiquitin and proteasome pathways
- Pituitary Gland Disorders and Treatments
- Diverticular Disease and Complications
- Congenital Diaphragmatic Hernia Studies
- Stoma care and complications
- Intestinal and Peritoneal Adhesions
Universitätsklinikum Würzburg
2016-2025
University Hospital Frankfurt
2024-2025
University of Würzburg
2016-2025
Comprehensive Cancer Center Mainfranken
2018-2025
Goethe University Frankfurt
2023-2025
Weatherford College
2023-2025
Disco (Germany)
2025
Universitäts-Kinderklinik Würzburg
2014-2024
Helmholtz Zentrum München
2023
Technion – Israel Institute of Technology
2023
In 2014, the International Endohernia Society (IEHS) published first international "Guidelines for laparoscopic treatment of ventral and incisional abdominal wall hernias." Guidelines reflect currently best available evidence in diagnostics therapy give recommendations to help surgeons standardize their techniques improve results. However, science is a dynamic field which continuously developing. Therefore, guidelines require regular updates keep pace with evolving literature.For development...
In 2014 the International Endohernia Society (IEHS) published first international "Guidelines for laparoscopic treatment of ventral and incisional abdominal wall hernias". Guidelines reflect currently best available evidence in diagnostics therapy give recommendations to help surgeons standardize their techniques improve results. However, science is a dynamic field which continuously developing. Therefore, guidelines require regular updates keep pace with evolving literature. For development...
Deregulated expression of MYC is a driver colorectal carcinogenesis, suggesting that inhibiting may have significant therapeutic value. The PI3K and mTOR pathways control turnover translation, respectively, providing rationale to target both inhibit MYC. Surprisingly, inhibition does not promote in colon carcinoma cells, but enhances because it promotes FOXO-dependent growth factor receptors MAPK-dependent transcription Inhibition fails translation MYC, levels 4EBPs are insufficient fully...
Abstract Deregulated expression of MYC is a driver colorectal carcinogenesis, necessitating novel strategies to inhibit function. The ubiquitin ligase HUWE 1 ( HECTH 9, ARF ‐ BP 1, MULE ) associates with both and the ‐associated protein MIZ 1. We show here that required for growth cancer cells in culture orthotopic xenograft models. Using high‐throughput screening, we identify small molecule inhibitors which ‐dependent transactivation cells, but not stem normal colon epithelial cells....
The in-hospital mortality after visceral surgery in Germany is unknown.In this retrospective, descriptive analysis, nationwide hospital billing data based on diagnosis-related groups (DRG) over the period 2009-2015 were studied to determine mortality, complications and their management, deaths documented severe (failure rescue, FTR) Germany. Organ-system subgroups defined subdivided into frequent operations (inguinal hernia repair, appendectomy, thyroid operations, cholecystec- tomy),...
Objective The epithelial layer of the GI tract is equipped with innate immune receptors to sense invading pathogens. Dysregulation in signalling pathways associated severe inflammatory diseases, but responsiveness cells bacterial stimulation remains unclear. Design We generated 42 lines human and murine organoids from gastric intestinal segments both adult fetal tissues. Genome-wide RNA-seq provides an expression atlas epithelium. response was assessed using several functional assays...
Acute appendicitis is one of the most common reasons for emergency medical consultation. While simple can be treated with antibiotics or surgery, complex including gangrene, abscess, and perforation requires appendectomy. During COVID-19 pandemic in early 2020, an overall drop room consultations was observed. We therefore aimed to investigate incidence treatment strategies acute during that period. Data insurance holders ICD code "acute appendicitis" OPS procedure appendectomy a major health...
Surgical site infections frequently occur after open abdominal surgery. Intraoperative wound irrigation as a preventive measure is common practice worldwide, although evidence supporting this lacking.
Abstract Purpose The management of soft tissue sarcoma (STS) at reference centers with specialized multidisciplinary tumor boards (MTB) improves patient survival. German Cancer Society (DKG) certifies in German-speaking countries, promoting high standards care. This study investigated the variability treatment recommendations for localized STS across different tertiary centers. Methods In this cross-sectional case-based survey study, 5 anonymized cases imaging data were presented to MTBs 21...
The transcriptional regulator BRD4 has been shown to be important for the expression of several oncogenes including MYC. Inhibiting broad antiproliferative activity in different cancer cell types. small molecule JQ1 blocks interaction with acetylated histones leading modulation. Depleting via engineered bifunctional molecules named PROTACs (proteolysis targeting chimeras) represents next-generation approach JQ1-mediated inhibition. trigger proteasomale degradation by recruiting E3 ligases....
BackgroundThe German Cancer Society ("Deutsche Krebsgesellschaft"; DKG) certifies on a volunteer base colorectal cancer centers based on, among other things, minimum operative amounts (at least 30 oncological colon resections and 20 rectal per year). In this work, nationwide hospital mortality death after documented complications ('Failure to Rescue' = FtR) were evaluated depending the fulfillment of amounts.MethodsThis is retrospective analysis billing data (DRG data, 2012–2017)....
Abstract Background The impact of hospital volume after rectal cancer surgery is seldom investigated. This study aimed to analyse the annual cases per on postoperative mortality and failure rescue. Methods All patients diagnosed with who had a resection procedure code from 2012 2015 were identified nationwide administrative data. Hospitals grouped into five quintiles according caseload. absolute number patients, deaths rescue (defined as in-hospital documented complication) for severe...
Abstract Dysregulation of extracellular signal-regulated kinases (ERK1/2) is linked to several diseases including heart failure, genetic syndromes and cancer. Inhibition ERK1/2, however, can cause severe cardiac side-effects, precluding its wide therapeutic application. ERK T188 -autophosphorylation was identified pathological hypertrophy. Here we report that interference with ERK-dimerization, a prerequisite for -phosphorylation, minimizes hypertrophy without inducing adverse effects: an...
Despite a long-known association between annual hospital volume and outcome, little progress has been made in shifting high-risk surgery to safer hospitals. This study investigates whether the risk-standardized mortality rate (RSMR) could serve as stronger proxy for surgical quality than volume.We included all patients who underwent complex oncologic surgeries Germany 2010 2018 any of five major cancer types, splitting data into training (2010-2015) validation sets (2016-2018). For each...
Abstract The human gastric epithelium forms highly organized gland structures with different subtypes of cells. carcinogenic bacterium Helicobacter pylori can attach to cells and subsequently translocate its virulence factor CagA, but the possible host cell tropism H. is currently unknown. Here, we report that preferentially attaches differentiated in pit region units. Single-cell RNA-seq shows organoid-derived monolayers recapitulate region, while organoids capture Using these models, show...
Colonic cancer is the most common of gastrointestinal tract. The aim this study was to determine mortality rates following colonic resection and effect hospital caseload on in-hospital in Germany. Patients admitted with a diagnosis undergoing from 2012 2015 were identified nationwide registry using procedure codes. outcome measure mortality. Hospitals ranked according their for resection, patients categorized into five subgroups basis volume. Some 129 196 resections reviewed. overall...