A5059056244- Hepatocellular Carcinoma Treatment and Prognosis
- Pancreatic and Hepatic Oncology Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Mechanisms and Therapy
- Galectins and Cancer Biology
- Signaling Pathways in Disease
- Cancer Immunotherapy and Biomarkers
- Renal cell carcinoma treatment
- Pancreatitis Pathology and Treatment
- Liver Disease and Transplantation
- Gallbladder and Bile Duct Disorders
- Neuropeptides and Animal Physiology
- Plant Virus Research Studies
- Liver physiology and pathology
- CAR-T cell therapy research
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Polyomavirus and related diseases
- Metabolomics and Mass Spectrometry Studies
- Colorectal Cancer Treatments and Studies
- Wnt/β-catenin signaling in development and cancer
- Cancer Risks and Factors
- Milk Quality and Mastitis in Dairy Cows
- Advanced Welding Techniques Analysis
- Gastric Cancer Management and Outcomes
- Receptor Mechanisms and Signaling
Heidelberg University
2019-2025
University Hospital Heidelberg
2019-2025
University Medical Centre Mannheim
2019-2025
University Hospital Ulm
2024-2025
Brigham and Women's Hospital
2022-2024
Harvard University
2022-2024
Heidelberg University
2024
RWTH Aachen University
2023
Medizinische Fakultät Mannheim
2022
Philipps University of Marburg
2018-2020
Surgical site infections frequently occur after open abdominal surgery. Intraoperative wound irrigation as a preventive measure is common practice worldwide, although evidence supporting this lacking.
Merkel cell carcinoma (MCC) is a rare and aggressive skin cancer. Inhibitors targeting the programmed death 1 (PD-1) immune checkpoint have improved MCC patient outcomes by boosting antitumor T immunity. Here, we identify PD-1 as growth-promoting receptor intrinsic to cells. In human lines clinical tumors, RT-PCR–based sequencing, immunoblotting, flow cytometry, immunofluorescence analyses demonstrated gene protein expression MCC–PD-1 ligation enhanced, its inhibition or silencing...
Programmed cell death 1 (PD-1) is a premier cancer drug target for immune checkpoint blockade (ICB). Because PD-1 receptor inhibition activates tumor-specific T-cell immunity, research has predominantly focused on T-cell-PD-1 expression and its immunobiology. In contrast, cell-intrinsic functional regulation not well understood. Here, we demonstrate induction of in melanoma cells via type I interferon (IFNAR) signaling reversal ICB efficacy through IFNAR pathway inhibition. Treatment with...
WNT1-inducible signalling pathway protein 1 (WISP1) promotes progression of several tumor entities often correlating with worse prognosis. Here its expression regulation and role in the chronic liver diseases (CLD) was investigated. WISP1 analyzed human HCC datasets, biopsies serum samples an patient tissue microarray (TMA) including correlation to clinicopathological parameters. Spatial distribution determined using RNAscope analysis. Regulation investigated cytokine-stimulated primary...
Analyses of metabolic compounds inside cells or tissues provide high information content since they represent the endpoint biological flow and are a snapshot integration many regulatory processes. However, quantification abundance metabolites requires their careful extraction. We present comprehensive study comparing ten extraction protocols in four human sample types (liver tissue, bone marrow, HL60, HEK cells) aiming to detect quantify up 630 different chemical classes. show that...
T-cell immunoglobulin mucin family member 3 (Tim-3) is an immune checkpoint receptor that dampens effector functions and causes terminal exhaustion of cytotoxic T cells. Tim-3 inhibitors are under investigation in immuno-oncology (IO) trials, because blockade T-cell-Tim-3 enhances antitumor immunity. Here, we identify additional role for as a growth-suppressive intrinsic to melanoma Inhibition cell-Tim-3 promoted tumor growth both immunocompetent immunocompromised mice, while...
Objective: To compare perioperative outcomes in patients undergoing minimally invasive liver surgery (MILR) with or without central venous pressure (CVP) reduction (≤5 mmHg). Background: Reduction CVP during parenchymal transection is widely accepted open hepatectomy to reduce intraoperative blood loss, as a major predictor of postoperative outcomes. However, the effect on loss MILR remains unclear. Methods: Randomized controlled, double-blinded trial. Patients elective between August 2020...
Laparoscopic liver resection (LLR) for lesions in the posterosuperior segments (PSS) is challenging. Identifying and minimizing risk factors postoperative morbidity mortality crucial. This retrospective cohort study shares initial experiences with LLR of PSS (VII, VIII, IVa) wants to identify clinically relevant complications (Clavien-Dindo grade ≥ III) these patients. We reviewed our prospective database all patients who underwent at least one lesion (April 2018-October 2022). Uni-...
Abstract Background Resection of centrally located liver lesions remains a technically demanding procedure. To date, there are limited data on the effectiveness and safety minimally invasive mesohepatectomy for benign malignant lesions. It was therefore objective this study to evaluate perioperative outcomes tumors at tertiary care hospital. Methods Consecutive patients who underwent anatomic using Glissonean pedicle approach from April 2018 November 2021 were identified prospective...
Importance Postpancreatectomy hemorrhage (PPH) due to postoperative pancreatic fistula (POPF) is a life-threatening complication after pancreatoduodenectomy. However, there no prediction tool for early identification of patients at high risk late PPH. Objective To develop and validate model Design, Setting, Participants This retrospective prognostic study included consecutive with clinically relevant POPF who underwent pancreatoduodenectomy from January 1, 2009, May 20, 2023, the University...
Abstract Monoclonal antibodies (abs) targeting the programmed cell death 1 (PD-1) immune checkpoint pathway have revolutionized tumor therapy. Because T-cell-directed PD-1 blockade boosts immunity, anti-PD-1 abs been developed for examining T-cell-PD-1 functions. More recently, expression has also reported directly on cancer cells of various etiology, including in melanoma. Nevertheless, there is a paucity studies validating ab clone utility specific assay types characterizing cell-intrinsic...
Background: Morbid obesity is a risk factor for pancreatic ductal adenocarcinoma (PDAC). However, the impact of on postoperative outcomes and overall survival in patients with PDAC remains controversial topic. Methods: Patients who underwent surgery between 1997 2018 were included this study. Matched pairs (1:1) generated according to age, gender American Society Anesthesiologists status. Obesity was defined WHO definition as BMI ≥ 30 kg/m2. The primary endpoint difference without obesity....
Chronic inflammation, linked to the presence of bovine milk and meat factors (BMMFs) specific subsets macrophages, results in oxygen radical synthesis induction mutations DNA actively replicating cells single stranded DNA. Cancers arising from this process have been characterized as indirect carcinogenesis by infectious agents (without persistence genes agent premalignant or cancers cells). Here, we investigate structural properties pleomorphic vesicles, regularly identified staining...
Abstract Major components of electrical machines are iron cores made stacked steel sheets. In this paper, pulsed laser beam welding in vacuum is used to join the individual Three different non-grain-oriented alloys investigated and joined by spot welds. The influence atmosphere as well on result tensile strength welded joint discussed. results show that insulation coating sheets has significant effects grain structure hardness weld spots. These can be reduced with decreased working pressure,...
Caustic ingestion may cause devastating injuries of the upper gastrointestinal tract and respiratory system. We report here successful treatment a 37-year-old patient who ingested hydrochloric acid (100 mL; 24%) in suicidal intention. An oesophagogastroduodenoscopy revealed extensive necrosis gastric mucosa. A diagnostic laparoscopy was performed confirmed suspected transmural which resulted discontinuous laparoscopic gastrectomy. During next days, oesophageal stump monitored through...