A5075949897- Radiomics and Machine Learning in Medical Imaging
- Advanced X-ray and CT Imaging
- Hepatocellular Carcinoma Treatment and Prognosis
- Pancreatic and Hepatic Oncology Research
- Acute Ischemic Stroke Management
- Renal cell carcinoma treatment
- Cardiac, Anesthesia and Surgical Outcomes
- MRI in cancer diagnosis
- Health Systems, Economic Evaluations, Quality of Life
- Liver Disease Diagnosis and Treatment
- Prostate Cancer Diagnosis and Treatment
- Clinical practice guidelines implementation
- Stroke Rehabilitation and Recovery
- Pelvic floor disorders treatments
- Colorectal Cancer Screening and Detection
- Aortic aneurysm repair treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Global Cancer Incidence and Screening
- Urinary Bladder and Prostate Research
- Explainable Artificial Intelligence (XAI)
- Telemedicine and Telehealth Implementation
- Renal and related cancers
- Traumatic Brain Injury Research
- Cardiac Imaging and Diagnostics
- Ultrasound in Clinical Applications
University Medical Centre Mannheim
2021-2025
University Hospital Heidelberg
2021-2025
Heidelberg University
2021-2025
University of California, Los Angeles
2024
Abstract Background Patients with epileptic seizures represent a significant proportion of emergency department (ED) admissions and are often referred for cranial imaging due to suspected or observed trauma. Neurological guidelines provide limited advice on indications in this scenario, traumatological clinical decision rules the use CT mild traumatic brain injury explicitly exclude patients preceding This gap recommendations may contribute overimaging trauma rule-out after seizure. Methods...
(1) Background: Tumoral heterogeneity (TH) is a major challenge in the treatment of metastatic colorectal cancer (mCRC) and associated with inferior response. Therefore, identification TH would be beneficial for planning. can assessed by identifying genetic alterations. In this work, radiomics-based approach assessment liver metastases (CRLM) CT scans demonstrated. (2) Methods: retrospective study, CRLM mCRC were segmented radiomics features extracted using pyradiomics. Unsupervised k-means...
The goal of this study is to demonstrate the performance radiomics and CNN-based classifiers in determining primary origin gastrointestinal liver metastases for visually indistinguishable lesions.In retrospective, IRB-approved study, 31 pancreatic cancer patients with 861 lesions (median age [IQR]: 65.39 [56.87, 75.08], 48.4% male) 47 colorectal 435 65.79 [56.99, 74.62], 63.8% were enrolled. A pretrained nnU-Net performed automated segmentation 1296 lesions. Radiomics features each lesion...
Abbreviated breast MRI (AB-MRI) was introduced to reduce both examination and image reading times improve cost-effectiveness of cancer screening. The aim this model-based economic study analyze the full protocol (FB-MRI) vs. AB-MRI in screening women with dense tissue for cancer.Decision analysis a Markov model were designed cumulative costs effects biennial terms quality-adjusted life years (QALYs) from US healthcare system perspective. Model input parameters cohort adopted recent...
Importance Postpancreatectomy hemorrhage (PPH) due to postoperative pancreatic fistula (POPF) is a life-threatening complication after pancreatoduodenectomy. However, there no prediction tool for early identification of patients at high risk late PPH. Objective To develop and validate model Design, Setting, Participants This retrospective prognostic study included consecutive with clinically relevant POPF who underwent pancreatoduodenectomy from January 1, 2009, May 20, 2023, the University...
The clinical use of photon-counting CT (PCCT) allows for the generation virtual non-contrast (VNC) series from contrast-enhanced images. In routine practice, specific issues such as ruling out acute bleeding require aim this study is to evaluate PCCT-derived VNC reconstructions in abdominal imaging. PCCT scans 17 patients including early arterial, portal venous and native sequences were enrolled. have been calculated. every sequence reconstruction, 10 ROIs measured (portal vein, descending...
Abdominal aortic aneurysms (AAA) may remain clinically silent until they enlarge and patients present with a potentially lethal rupture. This necessitates early detection elective treatment. The goal of this study was to develop an easy-to-train algorithm which is capable automated AAA screening in CT scans can be applied intra-hospital environment. Three deep convolutional neural networks (ResNet, VGG-16 AlexNet) were adapted for 3D classification dataset consisting 187 heterogenous scans....
Abstract Introduction The impact of the distance tumor from main hepatic vessels (DTV), such as Glissonean pedicle or veins, on oncological outcomes for Hepatocellular carcinoma (HCC) patients is relatively understudied. Therefore, objective this study was to explore correlation between DTV and survival in with HCC after curative resection. Methods Consecutive who underwent curative-intent liver surgery April 2018 May 2023 were identified a prospective database. Univariate multivariate Cox...
Abstract Background and Purpose Investigating the cost‐effectiveness of future mobile stroke unit (MSU) services with respect to local idiosyncrasies is essential for enabling large‐scale implementation MSU services. The aim this study was assess varying urban German settings modes operation. Methods Costs different operating times together personnel configurations were simulated. Different possible catchment zones, ischemic incidence, circadian distribution, rates alternative diagnoses, as...
Abstract Purpose Rectal cancer is one of the most frequent causes cancer-related morbidity and mortality in world. Correct identification TNM state primary staging rectal has critical implications on patient management. Initial evaluations revealed a high sensitivity specificity for whole-body PET/MRI detection metastases allowing metastasis-directed therapy regimens. Nevertheless, its cost-effectiveness compared with that standard-of-care imaging (SCI) using pelvic MRI + chest...
To evaluate the cost-effectiveness of MR-mammography (MRM) vs. x-ray based mammography (XM) in two-yearly screening women intermediate risk for breast cancer light recent literature.Decision analysis and Markov modelling were used to compare cumulative costs (in US-$) outcomes QALYs) MRM XM over model runtime 20 years. The perspective U.S. healthcare system was selected. Incremental ratios (ICER) calculated related a willingness pay-threshold $ 100,000 per QALY order cost-effectiveness....
Pancreatic cancer is portrayed to become the second leading cause of cancer-related death within next years. Potentially complicating surgical resection emphasizes importance an accurate TNM classification. In particular, failure detect features for non-resectability has profound consequences on patient outcomes and economic costs due incorrect indication resection. detection liver metastases, contrast-enhanced MRI showed high sensitivity specificity; however, cost-effectiveness compared...
Mobile stroke units (MSU) have been demonstrated to improve prehospital care in metropolitan and rural regions. Due geographical, social structural idiosyncrasies of the German city Mannheim, concepts established MSU services are not directly applicable Mannheim initiative. The aim present analysis was identify major determinants that need be considered when initially setting up a local service. Local statistics from 2015 2021 were analyzed circadian distribution strokes incidence rates...
Abstract Life-threatening acute aortic dissection (AD) demands timely diagnosis for effective intervention. To streamline intrahospital workflows, automated detection of AD in abdominal computed tomography (CT) scans seems useful to assist humans. We aimed at creating a robust convolutional neural network (CNN)-based pipeline capable real-time screening signs CT. In this retrospective study, CT data from patients presenting with and non-AD were collected ( n 195, cases 94, mean age 65.9...
Purpose This study aimed to determine the costs associated with prostatic artery embolization (PAE) performed in hospital and outpatient-based lab (OBL) settings. Methods Procedures were similarly equipped procedure suites located within a tertiary or OBL. Time-driven activity-based costing (TDABC) was utilized calculate procedural incurred by institution. Process maps created describing personnel, space, equipment, materials. The time duration of each step recorded independently nurse...
Background and purpose To simulate patient-level costs, analyze the economic potential of telemedicine-based mobile stroke units for acute prehospital care, identify major determinants cost-effectiveness, based on two recent prospective trials from United States Germany. Methods A Markov decision model was developed to lifetime costs outcomes unit. The compares diagnostic therapeutic pathways ischemic stroke, hemorrhagic mimic patients by conventional care or units. treatment were derived...
To characterize the relationship between ablation zone volume (AZV) and microwave (MWA) energy in an vivo porcine liver model following arterial embolization.
Background Microvascular invasion is a major histopathological risk factor of postoperative recurrence in patients with hepatocellular carcinoma. This study aimed to develop and validate digital biopsy model using imaging features predict microvascular before hepatectomy. Methods A total 217 consecutive who underwent hepatectomy for resectable carcinoma were enrolled at two tertiary-care reference centers. An imaging-based was developed internally validated logistic regression analysis...