A5036309711- Hepatocellular Carcinoma Treatment and Prognosis
- Colorectal Cancer Treatments and Studies
- Pancreatic and Hepatic Oncology Research
- Liver Disease and Transplantation
- Nutrition and Health in Aging
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Liver Disease Diagnosis and Treatment
- Cancer Treatment and Pharmacology
- Gastric Cancer Management and Outcomes
- Radiomics and Machine Learning in Medical Imaging
- Colorectal Cancer Surgical Treatments
- Esophageal Cancer Research and Treatment
- Gallbladder and Bile Duct Disorders
- Cancer Immunotherapy and Biomarkers
- Pancreatitis Pathology and Treatment
- Advanced X-ray and CT Imaging
- Angiogenesis and VEGF in Cancer
- Radiation Dose and Imaging
- Immune Response and Inflammation
- Medical Imaging Techniques and Applications
- Lung Cancer Diagnosis and Treatment
- Esophageal and GI Pathology
- Inflammatory Biomarkers in Disease Prognosis
- Abdominal Surgery and Complications
- Colorectal and Anal Carcinomas
Medical University of Vienna
2016-2025
Comprehensive Cancer Center Vienna
2016-2025
Vienna General Hospital
2011-2024
Hanusch Hospital
2021
Boehringer Ingelheim (Austria)
2005-2019
Klinik und Poliklinik für Nuklearmedizin
2017-2019
Kaiser-Franz-Josef-Spital
2019
Innsbruck Medical University
2019
Universität Innsbruck
2019
Memorial Sloan Kettering Cancer Center
2012-2015
Abstract Toll‐like receptors (TLR) represent an ancient front‐line defence system that enables the host organism to sense presence of microbial components within minutes. As inducers inflammation, TLR act as important triggers distinct entities such sepsis or autoimmune disease exacerbation. We report here vitamin D3 [1α,25‐dihydroxycholecalciferol, 1,25(OH) 2 D3] suppresses expression TLR2 and TLR4 protein mRNA in human monocytes a time‐ dose‐dependent fashion. Despite D3‐induced...
Patients with colorectal cancer (CRC) and liver metastases have a poor prognosis, but can benefit from perioperative chemotherapy disease resection. Bevacizumab improves outcomes in patients metastatic CRC; however, its impact on surgical complications hepatic regeneration after resection remains to be determined.Fifty-six CRC potentially curable by were eligible for this single-center, nonrandomized phase II trial. Eligibility criteria defined at high risk of early recurrence. received...
PET/MRI has recently been introduced into clinical practice. We prospectively investigated the impact of compared with PET/CT, in a mixed population cancer patients, and performed an economic evaluation PET/MRI. Cancer patients referred for routine staging or follow-up by PET/CT underwent consecutive PET/MRI, using single applications [18F]FDG, [68Ga]Ga-DOTANOC, [18F]FDOPA, depending on tumor histology. were rated separately, lesions assessed per anatomic region; based regions,...
Remarkably limited information is available about biological mechanisms that determine the disease entity of metastatic colorectal cancer in liver (CRCLM) with no good clinical parameters to estimate prognosis. For last few years, understanding relationship between tumor characteristics and local immune response has gained increasing attention. Given multifaceted roles B-cell-driven responses, we aimed elucidate immunological imprint B lymphocytes at site, interrelation macrophages, their...
Background Incidence and mortality of pancreatic ductal adenocarcinoma (PDAC) are on the rise. Sarcopenia sarcopenic obesity have proven to be prognostic factors in different types cancers. In context previous findings, we evaluated impact body composition patients undergoing surgery a national center. Methods Patient's (n = 133) was analyzed diagnostic CT scans defined as follows: Skeletal muscle index ≤38.5 cm2/m2 (women), ≤52.4 (men); classified BMI ≥25kg/m2. Results showed negative...
Surgical resection of liver metastases arising from colorectal cancer is considered the only curative treatment option. However, many patients subsequently experience disease recurrence. We prospectively investigated whether neoadjuvant chemotherapy reduces risk recurrence following potentially resection. Special emphasis was directed to importance response. 50 with resectable received XELOX or FOLFOX4 for six cycles (3 months). Complete intended thereafter. Assessments included response...
Abstract Background The aim of this study was to examine the relationship between surgical margin status and site recurrence after potentially curative liver resection for colorectal metastases using an ultrasonic dissection technique. Methods Between January 2000 December 2003, 176 patients underwent with intent at a single institution. Demographics, operative data, pathological status, long-term survival data were collected prospectively analysed. Results On analysis, margins positive in...
Purpose To determine whether gadoxetic acid–enhanced magnetic resonance (MR) imaging can be used to distinguish between simple steatosis and nonalcoholic steatohepatitis (NASH) in patients with fatty liver disease (NAFLD), defined according the activity fibrosis (SAF) scoring system, which is based on semiquantitative of fibrosis. Materials Methods The local institutional review committee approved this study waived written informed consent. This was a retrospective 3-T MR performed 81 NAFLD...
Neoadjuvant chemotherapy (neoCTx) followed by hepatic resection is the treatment of choice for patients with colorectal cancer liver metastasis (CLM). Treatment response generally assessed using radiologic imaging after several cycles chemotherapy. However, earlier assessment would be desirable since nonresponders could switched early to an alternative regimen. Recent evidence suggests that circulating free methylated tumor DNA a highly sensitive biomarker and may more accurately reflect...
Background Gadoxetic acid-enhanced MRI enables estimation of liver function in patients with chronic disease (CLD). The functional imaging score (FLIS), derived from gadoxetic MRI, has been shown to predict transplant-free survival transplant patients. Purpose To investigate the accuracy FLIS for predicting hepatic decompensation and CLD. Materials Methods Patients CLD who had undergone including T1-weighted volume-interpolated breath-hold examination sequences fat suppression, performed...
Prior work has shown improved image quality for photon-counting detector (PCD) CT of the lungs compared with energy-integrating CT. A paucity literature PCD using different reconstruction parameters.
Abstract Background Intrahepatic cholangiocarcinoma (ICC) is rare but its incidence rising worldwide. The value of lymph node dissection for ICC under discussion; the current staging systems do not differentiate between numbers involved nodes. Methods Ninety-three patients who underwent laparotomy 1997 and 2007 were identified retrospectively; 46 curative resection systematic lymphadenectomy around hepatoduodenal ligament analysed further. Univariable multivariable regression analysis was...
Abstract Background The prognostic value of KRAS mutation in patients with colorectal cancer liver metastases (CLM) receiving neoadjuvant chemotherapy including bevacizumab before resection is unclear. Methods and BRAF status resected CLM was assessed prospectively studied patients. Mutations were correlated recurrence-free overall survival. Only remaining vital tumour cells the specimen those without disease progression analysed; progressive did not undergo resection. Results A total 60...
Objective The aim of this study was to evaluate the prognostic potential a 3-parameter visual scoring (qualitative score [QS]) system for hepatobiliary phase gadoxetic acid–enhanced magnetic resonance imaging (MRI) in orthotopic liver transplant grafts. Materials and Methods This retrospective 128 patients approved by our institutional review board. Two readers independently assigned 3 QSs T1-weighted MRI scans, 20 minutes after administration acid (hepatobiliary phase), based upon...