A5033827323- Melanoma and MAPK Pathways
- Computational Drug Discovery Methods
- Immune cells in cancer
- Cancer Immunotherapy and Biomarkers
- Sphingolipid Metabolism and Signaling
- Click Chemistry and Applications
- interferon and immune responses
- Immune Cell Function and Interaction
- Phagocytosis and Immune Regulation
- Peptidase Inhibition and Analysis
- Ferroptosis and cancer prognosis
- Immunotherapy and Immune Responses
- Cancer, Hypoxia, and Metabolism
- Lung Cancer Treatments and Mutations
- RNA modifications and cancer
- Cell Adhesion Molecules Research
- SARS-CoV-2 and COVID-19 Research
- Cancer-related molecular mechanisms research
- COVID-19 Clinical Research Studies
- T-cell and B-cell Immunology
- Hepatocellular Carcinoma Treatment and Prognosis
- Estrogen and related hormone effects
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Mast cells and histamine
- Vestibular and auditory disorders
Medical University of Vienna
2015-2024
Yugra State University
2022-2023
University of Ostrava
2022
Christian Doppler Laboratory for Thermoelectricity
2014
Comprehensive Cancer Center Vienna
2012
Millennium Institute on Immunology and Immunotherapy
2012
University of Chile
2012
Uppsala University
2012
Remarkably limited information is available about biological mechanisms that determine the disease entity of metastatic colorectal cancer in liver (CRCLM) with no good clinical parameters to estimate prognosis. For last few years, understanding relationship between tumor characteristics and local immune response has gained increasing attention. Given multifaceted roles B-cell-driven responses, we aimed elucidate immunological imprint B lymphocytes at site, interrelation macrophages, their...
The pathogenesis of multiple myeloma (MM) is regarded as a multistep process, in which an asymptomatic stage monoclonal gammopathy undetermined significance (MGUS) precedes virtually all cases MM. Molecular events characteristic for the transition from MGUS to MM are still poorly defined. We hypothesized that fibroblast-like cells tumor microenvironment critically involved Therefore, we performed comparative proteome profiling study, analyzing primary human isolated bone marrow MM, MGUS,...
Proteome profiling is the method of choice to identify marker proteins whose expression may be characteristic for certain diseases. The formation such results from disease-related pathophysiologic processes. In healthy individuals, peripheral blood mononuclear cells (PBMCs) circulate in a quiescent cell state monitoring potential immune-relevant events, but have competence respond quickly and efficiently an inflammatory manner any invasion pathogens. Activation these most plausibly...
The calcium sensing receptor (CaSR), a calcium-binding G protein-coupled is expressed also in tissues not directly involved homeostasis like the colon. We have previously reported that CaSR expression down-regulated colorectal cancer (CRC) and loss of provides growth advantage to transformed cells. However, detailed mechanisms underlying these processes are largely unknown. In cohort 111 CRC patients, we found significant inverse correlation between markers epithelial-to-mesenchymal...
Abstract The FDA-approved BRAF inhibitor vemurafenib achieves outstanding clinical response rates in patients with melanoma, but early resistance is common. Understanding the pathologic mechanisms of drug and identification effective therapeutic alternatives are key scientific challenges melanoma setting. Using proteomic techniques, including shotgun analysis 2D-gel electrophoresis, we identified a comprehensive signature vemurafenib-resistant M24met comparison vemurafenib-sensitive A375...
Fibroblasts are mesenchymal stromal cells which occur in all tissue types. While their main function is related to ECM production and physical support, they also important players wound healing, have further been recognized be able modulate inflammatory processes support tumor growth. can display distinct phenotypes, depending on origin, as well functional state.In order contribute the proteomic characterization of fibroblasts, we isolated primary human fibroblasts from skin, lung bone...
// Anastasia Meshcheryakova 1 , Martin Svoboda 1, * Ammar Tahir 2, 3, Harald C. Köfeler 4 Alexander Triebl Felicitas Mungenast Georg Heinze 5 Christopher Gerner 3 Philip Zimmermann 6 Markus Jaritz 7 Diana Mechtcheriakova Department of Pathophysiology and Allergy Research, Medical University Vienna, Austria 2 Institute Analytical Chemistry, Mass Spectrometry Center, Core Facility for Spectrometry, Center Graz, Section Clinical Biometrics, Statistics, Informatics, Intelligent Systems, Nebion...
Langerhans cell (LC) networks play key roles in immunity and tolerance at body surfaces. LCs are established prenatally can be replenished from blood monocytes. Unlike skin-resident dermal DCs (dDCs)/interstitial-type inflammatory dendritic epidermal cells appearing dermatitis/eczema lesions, lack monocyte-affiliated markers. Inversely, express various epithelial genes critical for their long-term peripheral tissue residency.Dendritic (DCs) functionally involved diseases; however, the...
The sphingolipid and lysophosphatidate regulatory networks impact diverse mechanisms attributed to cancer cells the tumor immune microenvironment. Deciphering complexity demands implementation of a holistic approach combined with higher-resolution techniques. We implemented multi-modular integrative consolidating latest accomplishments in gene expression profiling, prognostic/predictive modeling, next generation digital pathology, systems biology for epithelial ovarian cancer. assessed...
Leishmania spp. represent human pathogens that cause leishmaniasis, a widespread parasitic disease with mild to fatal clinical manifestations. Some strains of leishmaniae bear leishmaniaviruses (LRVs), and this has been shown aggravate course.
The Mukhrino field station has participated in the national project on inventory of carbon fluxes and pools terrestrial ecosystems Russia since 2022. development a network measurements CO2 phytomass covered six types bog typical to Western Siberia. gross ecosystem exchange (GEE) field-layer vegetation (medians for period from end May July, mgC m−2 h−1; see errors Results section) decreased series: Sphagnum with sparse low pine trees (“Open bog”), ridges ridge-hollow patterned bogs (“Ridge”),...
The role of resveratrol (RES) in preventing breast cancer is controversial, as low concentrations may stimulate the proliferation estrogen-receptor alpha positive (ERα+) cells. As metabolism key factor altering cellular estrogens, thereby influencing tumor growth, we investigated effects RES on formation estrogen metabolites, namely 4-androstene-1,17-dione (AD), dehydroepiandrosterone (DHEA), dehydroepiandrosterone-3-O-sulfate (DHEA-S), estrone (E1), estrone-3-sulfate (E1-S), 17β-estradiol...
Cells gain their functional specialization by different protein synthesis. A lot of knowledge with respect to cell type‐specific proteins has been collected during the last thirty years. This was built mainly using antibodies. Nowadays, modern MS, which supports comprehensive proteome analyses biological samples, may render possible search for as well. However, a therefore necessary systematic MS study comprising many types not performed until now. Here we present analysis strategy...
Building up of pathway-/disease-relevant signatures provides a persuasive tool for understanding the functional relevance gene alterations and network associations in multifactorial human diseases. Ovarian cancer is highly complex heterogeneous malignancy respect tumor anatomy, microenvironment including pro-/antitumor immunity inflammation; still, it generally treated as single disease. Thus, further approaches to investigate novel aspects ovarian pathogenesis aiming provide personalized...
The AID (activation-induced cytidine deaminase)/APOBEC (apolipoprotein B mRNA editing enzyme catalytic subunit) family with its multifaceted mode of action emerges as potent intrinsic host antiviral system that acts against a variety DNA and RNA viruses including coronaviruses. All members are cytosine-to-uracil deaminases either have profound role in driving strong specific humoral immune response (AID) or restricting the virus itself by plethora mechanisms (APOBECs). In this article, we...
A crucial role of cell metabolism in immune differentiation and function has been recently established. Growing evidence indicates that metabolic processes impact both, innate adaptive immunity. Since a down-stream integrator alterations, mammalian target rapamycin (mTOR), is responsible for controlling the balance between pro-inflammatory interleukin (IL)-12 anti-inflammatory IL-10, we investigated effect upstream interference using modulators on production pro- cytokines. Cytokine release...
Abstract Neuroendocrine tumors may present with pseudoallergic reactions like diarrhea and idiopathic anaphylaxis. Here we the P-STS human ileal neuroendocrine cell line as a model for these tumors. markers changes in cytoplasmic calcium concentration ([Ca 2+ ] i ) response to several possible activators of 5-hydroxytryptamine (5-HT) release were analyzed. cells still expressed chromogranin A synaptophysin after 2 years culture. Tryptophan hydroxylase 1 mRNA low amount 5-HT also detected....
High-grade serous ovarian cancer (HGSOC) is currently treated with cytoreductive surgery and platinum-based chemotherapy. The majority of patients show a primary response; however, many rapidly develop drug resistance. Antiestrogens have been studied as low toxic treatment options for HGSOC, higher response rates in platinum-sensitive cases. Mechanisms this difference remain unknown. Therefore, the present study investigated impact platinum resistance on steroid metabolism six established...
The gut-associated lymphoid tissue represents an integral part of the immune system. Among powerful players mucosa-associated are isolated structures (ILSs), which as information centers, drive local (and systemic) adaptive responses. Germinal center reactions, taking place within ILSs, involve coordinated action various cell types with a central role given to B cells. In current study, we aimed at dissecting impact ILSs non-tumorous colon (NT) on pathobiology colorectal cancer (CRC)...
cDC2s occur abundantly in peripheral tissues and arise from circulating blood cDC2s. However, the factors governing cDC2 differentiation tissues, especially under inflammatory conditions, remained poorly defined. We here found that psoriatic express efferocytosis receptor Axl exhibit a bone morphogenetic protein (BMP) p38MAPK signaling signature. BMP7, strongly expressed within lesional epidermis, cooperates with canonical TGF-β1 for inducing