A5040998934- Estrogen and related hormone effects
- Aldose Reductase and Taurine
- Hormonal Regulation and Hypertension
- Endometriosis Research and Treatment
- Steroid Chemistry and Biochemistry
- Reproductive System and Pregnancy
- Endometrial and Cervical Cancer Treatments
- Pharmacogenetics and Drug Metabolism
- Uterine Myomas and Treatments
- X-ray Diffraction in Crystallography
- Hormonal and reproductive studies
- Crystallization and Solubility Studies
- Prenatal Substance Exposure Effects
- Ovarian cancer diagnosis and treatment
- Plant biochemistry and biosynthesis
- Bioactive Compounds and Antitumor Agents
- Eicosanoids and Hypertension Pharmacology
- Crystallography and molecular interactions
- Cancer, Lipids, and Metabolism
- Drug Transport and Resistance Mechanisms
- Angiogenesis and VEGF in Cancer
- Genomics, phytochemicals, and oxidative stress
- Microbial Natural Products and Biosynthesis
- Enzyme Structure and Function
- Heme Oxygenase-1 and Carbon Monoxide
University of Ljubljana
2016-2025
Mashhad University of Medical Sciences
2023
University of Nebraska Medical Center
2021
Translational Therapeutics (United States)
2021
GTx (United States)
2018
Inštitut Bion
2016
Faculty (United Kingdom)
2016
National Institute of Chemistry
2008
University of Pennsylvania
2003-2007
Current non-invasive diagnostic methods for endometriosis lack sensitivity and specificity. In search new biomarkers ovarian endometriosis, we used a hypothesis-generating targeted metabolomics approach.In case-control study, collected plasma of study participants analysed their metabolic profiles. We selected group 40 patients with who underwent laparoscopic surgery control 52 healthy women sterilization at the University Clinical Centre Ljubljana, Slovenia. Over 140 analytes included...
Endometriosis is defined as the presence of endometrial glands and stroma within extrauterine sites, it well known that endometriosis an estrogen-dependent disease. The defective formation metabolism steroid hormones responsible for promotion development endometriosis. In present study we examined mRNA levels six enzymes are involved in estrogen progesterone – aromatase, 17β-hydroxysteroid dehydrogenase (17β-HSD) types 1, 2 7, sulfatase sulfotransferase receptors α β (ERα, ERβ) A B (PRAB)...
Human aldo-keto reductases (AKRs) of the AKR1C subfamily function in vitro as 3-keto-, 17-keto-, and 20-ketosteroid or 3alpha-, 17beta-, 20alpha-hydroxysteroid oxidases. These AKRs can convert potent sex hormones (androgens, estrogens, progestins) into their cognate inactive metabolites vice versa. By controlling local ligand concentration may regulate steroid hormone action at prereceptor level. AKR1C2 is expressed prostate, it will catalyze nicotinamide adenine dinucleotide...
Nine organoruthenium complexes with azole antifungal agents (L) clotrimazole (ctz), tioconazole (tcz), and miconazole (mcz) the general formulas [(η6-p-cymene)RuCl2(L)], [(η6-p-cymene)RuCl(L)2]Cl, [(η6-p-cymene)Ru(L)3](PF6)2 were prepared characterized by NMR, HRMS, IR, UV–vis, X-ray crystallography. Herein, we report first crystal structure of a metal complex as well ligand itself bis-clotrimazole hexafluorophosphate salt. The possess pseudooctahedral geometry typical for...
Can cartilage oligomeric matrix protein (COMP) and transforming growth factor-β-induced ig-h3 (TGFBI) alone or in combination with cancer antigen 125 (CA-125) be considered as potential blood biomarkers of endometriosis?The results this study indicate that COMP has no diagnostic value. TGFBI a non-invasive biomarker the early stages endometriosis, while together CA-125 similar characteristics for all endometriosis.Endometriosis is common, chronic gynecological disease significantly affects...
A novel cytochrome P450, CYP53A15, was identified in the pathogenic filamentous ascomycete Cochliobolus lunatus. The protein, classified into CYP53 family, capable of para hydroxylation benzoate. Benzoate is a key intermediate metabolism aromatic compounds fungi and yet basically toxic to organism. To guide functional analyses, protein structure predicted by homology modeling. Since many naturally occurring antifungal phenolic are structurally similar CYP53A15 substrates, we tested their...