A5015345650- Radiomics and Machine Learning in Medical Imaging
- Medical Imaging Techniques and Applications
- Liver Disease Diagnosis and Treatment
- MRI in cancer diagnosis
- Cancer Immunotherapy and Biomarkers
- Ovarian cancer diagnosis and treatment
- Advanced NMR Techniques and Applications
- Liver Disease and Transplantation
- Mesenchymal stem cell research
- Lung Cancer Diagnosis and Treatment
- RNA Interference and Gene Delivery
- COVID-19 diagnosis using AI
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Artificial Intelligence in Healthcare and Education
- Extracellular vesicles in disease
- Lung Cancer Treatments and Mutations
- Advanced X-ray and CT Imaging
- Nutrition and Health in Aging
- Atomic and Subatomic Physics Research
- Medical Imaging and Pathology Studies
- Advanced MRI Techniques and Applications
- Privacy-Preserving Technologies in Data
- Cardiac Fibrosis and Remodeling
- Pleural and Pulmonary Diseases
- Radiation Dose and Imaging
Medical University of Vienna
2016-2025
Comprehensive Cancer Center Vienna
2025
Cancer Research UK
2019-2025
Cancer Research UK Cambridge Center
2019-2025
Christian Doppler Laboratory for Thermoelectricity
2012-2024
Klinik und Poliklinik für Nuklearmedizin
2016-2023
University of Cambridge
2019-2023
Vienna General Hospital
2023
University of Massachusetts Chan Medical School
2022
UMass Memorial Medical Center
2022
Machine learning methods offer great promise for fast and accurate detection prognostication of COVID-19 from standard-of-care chest radiographs (CXR) computed tomography (CT) images. Many articles have been published in 2020 describing new machine learning-based models both these tasks, but it is unclear which are potential clinical utility. In this systematic review, we search EMBASE via OVID, MEDLINE PubMed, bioRxiv, medRxiv arXiv papers preprints uploaded January 1, to October 3,...
PET/MRI has recently been introduced into clinical practice. We prospectively investigated the impact of compared with PET/CT, in a mixed population cancer patients, and performed an economic evaluation PET/MRI. Cancer patients referred for routine staging or follow-up by PET/CT underwent consecutive PET/MRI, using single applications [18F]FDG, [68Ga]Ga-DOTANOC, [18F]FDOPA, depending on tumor histology. were rated separately, lesions assessed per anatomic region; based regions,...
Abstract We previously showed that, when peripheral blood mononuclear cells (PBMCs) were stressed with ionizing radiation, they released paracrine factors that regenerative capacity in vitro and vivo . This study aimed to characterize the secretome of PBMCs investigate its biologically active components Bioinformatics analysis revealed irradiated differentially expressed genes encoded secreted proteins. These primarily involved (a) pro-angiogenic pathways (b) generation oxidized...
Differentiating aggressive clear cell renal carcinoma (ccRCC) from indolent lesions is challenging using conventional imaging. This work prospectively compared the metabolic imaging phenotype of tumors carbon-13 MRI following injection hyperpolarized [1-
Abstract High grade serous ovarian carcinoma (HGSOC) is a highly heterogeneous disease that typically presents at an advanced, metastatic state. The multi-scale complexity of HGSOC major obstacle to predicting response neoadjuvant chemotherapy (NACT) and understanding critical determinants response. Here we present framework predict the patients NACT integrating baseline clinical, blood-based, radiomic biomarkers extracted from all primary lesions. We use ensemble machine learning model...
Background Gadoxetic acid-enhanced MRI enables estimation of liver function in patients with chronic disease (CLD). The functional imaging score (FLIS), derived from gadoxetic MRI, has been shown to predict transplant-free survival transplant patients. Purpose To investigate the accuracy FLIS for predicting hepatic decompensation and CLD. Materials Methods Patients CLD who had undergone including T1-weighted volume-interpolated breath-hold examination sequences fat suppression, performed...
Abstract Artificial intelligence provides a promising solution for streamlining COVID-19 diagnoses; however, concerns surrounding security and trustworthiness impede the collection of large-scale representative medical data, posing considerable challenge training well-generalized model in clinical practices. To address this, we launch Unified CT-COVID AI Diagnostic Initiative (UCADI), where artificial (AI) can be distributedly trained independently executed at each host institution under...
Background Photon-counting detector (PCD) CT enables ultra-high-resolution lung imaging and may shed light on morphologic correlates of persistent symptoms after COVID-19. Purpose To compare PCD with energy-integrating (EID) for noninvasive assessment post-COVID-19 abnormalities. Materials Methods For this prospective study, adult participants one or more COVID-19-related persisting (resting exertional dyspnea, cough, fatigue) underwent same-day EID between April 2022 June 2022. The 1.0-mm...
Prior work has shown improved image quality for photon-counting detector (PCD) CT of the lungs compared with energy-integrating CT. A paucity literature PCD using different reconstruction parameters.
Congestive heart failure developing after acute myocardial infarction (AMI) is a major cause of morbidity and mortality. Clinical trials cell-based therapy AMI evidenced only moderate benefit. We could show previously that suspensions apoptotic peripheral blood mononuclear cells (PBMC) are able to reduce damage in rat model AMI. Here we experimentally examined the biochemical mechanisms involved preventing ventricular remodelling preserving cardiac function Cell were injected intravenously...
The aim of this study was to compare the Response Evaluation Criteria in Solid Tumors (RECIST) 1.1, immune RECIST (iRECIST) criteria, and Positron Emission Tomography (PERCIST) 1.0 patients with advanced non-small cell lung cancer treated programmed death protein 1 (PD-1)/programmed ligand (PD-L1) inhibitors.This prospective 42 a PD-1/PD-L1 inhibitor approved by our institutional review board, all gave written, informed consent. Tumor burden dynamics were assessed on F-FDG PET/CT before...
Purpose To compare hyperpolarized carbon 13 (13C) MRI with dynamic contrast material–enhanced (DCE) in the detection of early treatment response breast cancer. Materials and Methods In this institutional review board–approved prospective study, a woman triple-negative cancer (age, 49 years) underwent 13C after injection [1–carbon {13C}]-pyruvate DCE at 3 T baseline one cycle neoadjuvant therapy. The 13C-labeled lactate-to-pyruvate ratio derived from pharmacokinetic parameters transfer...
The aim of this study was to assess the objective and subjective image characteristics monoenergetic images (MEI[+]), using a noise-optimized algorithm at different kiloelectron volts (keV) compared polyenergetic (PEI), in patients with pancreatic ductal adenocarcinoma (PDAC). This retrospective, institutional review board-approved included 45 (18 male, 27 female; mean age 66 years; range, 42–96 years) PDAC who had undergone dual-energy CT (DECT) abdomen for staging. One standard (PEI) five...
Cancer typically exhibits genotypic and phenotypic heterogeneity, which can have prognostic significance influence therapy response. Computed Tomography (CT)-based radiomic approaches calculate quantitative features of tumour heterogeneity at a mesoscopic level, regardless macroscopic areas hypo-dense (i.e., cystic/necrotic), hyper-dense calcified), or intermediately dense soft tissue) portions.
Abstract Burn wounds pose a serious threat to patients and often require surgical treatment. Skin grafting aims achieve wound closure but requires well-vascularized bed. The secretome of peripheral blood mononuclear cells (PBMCs) has been shown improve healing angiogenesis. We hypothesized that topical application the PBMC would quality regenerating skin, increase angiogenesis, reduce scar formation after burn injury skin in porcine model. Full-thickness injuries were created on back female...
High dose ionizing radiation (IR) induces potent toxic cell effects mediated by either direct DNA damage or the production of reactive oxygen species (ROS). IR-induced modulations in multiple biological processes have been proposed to be partly regulated radiosensitive microRNA (miRNA). In order gain new insights into role miRNAs regulation after IR, we investigated changes mRNA and miRNA expression high IR. IR induced profiles human peripheral blood mononuclear cells (PBMCs). When comparing...
<ns4:p>The pursuit of targeting multiple pathways in the ischemic cascade cerebral stroke is a promising treatment option. We examined regenerative potential conditioned medium derived from rat and human apoptotic mononuclear cells (MNC), rMNC<ns4:sup>apo sec</ns4:sup> hMNC<ns4:sup>apo sec</ns4:sup>, experimental stroke.</ns4:p><ns4:p>We performed middle artery occlusion on Wistar rats administered MNC-secretomes intraperitoneally two settings. Ischemic lesion volumes were determined 48...
Secretomes from various cell sources exert strong regenerative activities on numerous organs, including the skin. Although secretomes consist of many diverse components, a growing body evidence suggests that small extracellular vesicles (EVs) account for their capacity. We previously demonstrated secretome γ-irradiated peripheral blood mononuclear cells (PBMCs) exhibits wound healing Therefore, we sought to dissect molecular composition EVs present in and compared healing-related these other...
Abstract Objectives To investigate the association between CT imaging traits and texture metrics with proteomic data in patients high-grade serous ovarian cancer (HGSOC). Methods This retrospective, hypothesis-generating study included 20 HGSOC prior to primary cytoreductive surgery. Two readers independently assessed contrast-enhanced computed tomography (CT) images extracted 33 traits, a third reader adjudicating event of disagreement. In addition, all sites suspected were manually...
Abstract Background & Aims To explore whether sarcopenia, diagnosed by an abbreviated magnetic resonance imaging (MRI) protocol is a risk factor for hepatic decompensation and mortality in patients with chronic liver disease (CLD). Methods In this retrospective single‐centre study we included 265 (164 men, mean age 54 ± 16 years) CLD who had undergone MRI of the between 2010 2015. Transverse psoas muscle thickness (TPMT) was measured on unenhanced contrast‐enhanced T1‐weighted...