A5030343627- Electrospun Nanofibers in Biomedical Applications
- Sepsis Diagnosis and Treatment
- Mesenchymal stem cell research
- Immune Response and Inflammation
- Tissue Engineering and Regenerative Medicine
- Hemostasis and retained surgical items
- Wound Healing and Treatments
- Periodontal Regeneration and Treatments
- Bone Tissue Engineering Materials
- Respiratory Support and Mechanisms
- Nerve injury and regeneration
- 3D Printing in Biomedical Research
- Hernia repair and management
- Silk-based biomaterials and applications
- Bone fractures and treatments
- Surgical Sutures and Adhesives
- Nitric Oxide and Endothelin Effects
- Osteoarthritis Treatment and Mechanisms
- Orthopaedic implants and arthroplasty
- Cardiac Arrest and Resuscitation
- Traumatic Brain Injury and Neurovascular Disturbances
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Tendon Structure and Treatment
- S100 Proteins and Annexins
- Pelvic and Acetabular Injuries
Ludwig Boltzmann Institute for Experimental and Clinical Traumatology
2016-2025
Austrian Cluster for Tissue Regeneration
2016-2025
Ludwig Boltzmann Institute for Digital Health and Prevention
2015-2025
Ludwig Boltzmann Gesellschaft
2021-2024
University of Vienna
1995-2021
University of Applied Sciences Technikum Wien
2021
BD Biosciences (United States)
2019
BioLegend (United States)
2019
Allgemeine Unfallversicherungsanstalt
2003-2018
Atos (France)
2018
Forced expression of selected transcription factors can transform somatic cells into embryonic stem cell (ESC)-like cells, termed induced pluripotent (iPSCs). There is no consensus regarding the preferred tissue from which to harvest donor for reprogramming iPSCs, and some types may be more prone than others accumulation epigenetic imprints mutations. Here, we present a simple, reproducible, noninvasive method generating human iPSCs renal tubular in urine. This procedure eliminates many...
Bone marrow-derived mesenchymal stem cells (BMSCs) have been used for allogeneic application in tissue engineering but certain drawbacks. Therefore, (SC)s derived from other adult sources considered as an alternative. However, there is only limited knowledge on their immunomodulatory properties. The aim of our study was to compare the potential human amniotic and epithelial with that adipose-derived SCs under identical experimental conditions. We demonstrated a dose-dependent inhibition...
Research indicates that glial fibrillary acidic protein (GFAP), part of the astroglial skeleton, could be a marker traumatic brain injury (TBI). S100B, an protein, is acknowledged TBI. Our goal was to analyze relationship GFAP/S100B damage and outcome, compare accuracy for prediction mortality after prospective study included 92 patients admitted <12 h TBI (median severity score 25, median Glasgow Coma Scale 6). verfied by computerized tomography. were measured immunoluminometrically at...
ABSTRACT Preclinical animal studies precede the majority of clinical trials. While definitions sepsis and recommended treatments are regularly updated, a systematic review preclinical models has not been done clear modeling guidelines lacking. To address this deficit, Wiggers-Bernard Conference on was held in Vienna May, 2017. The goal conference to identify limitations propose set guidelines, defined as “ Minimum Quality Threshold Sepsis Studies ” (MQTiPSS), enhance translational value...
Damage to cells and tissues is one of the driving forces aging age-related diseases. Various repair systems are in place counteract this functional decline. In particular, property adult stem self-renew differentiate essential for tissue homeostasis regeneration. However, their functionality declines with age (Rando, 2006). One organ that notably affected by reduced differentiation capacity skeleton. Here, we found circulating microvesicles impact on osteogenic mesenchymal a...
Context: Established bone turnover markers do not reflect fracture risk in idiopathic male and premenopausal osteoporosis the role of microRNAs (miRNAs) these patients is currently unclear. miRNAs are a class small non-coding RNAs that regulate gene expression tissue homeostasis. They considered new endocrine regulators with promising potential as biomarkers. Objective: Evaluation circulating miRNA signatures female subjects postmenopausal osteoporotic low-traumatic fractures. Design,...
Arginine vasopressin (AVP) levels are increased in hemorrhagic and septic shock. Measurement of AVP has limitations due to its short half-life cumbersome detection method. Copeptin is a more stable peptide derived from the same precursor molecule. We evaluated plasma copeptin concentration two independent studies: first, an experimental baboon model shock, second, prospective observational study 101 consecutive critically ill patients at university hospital. was measured with newly developed...
Background: This study aimed to determine whether glial fibrillary acidic protein (GFAP) is released after traumatic brain injury (TBI), GFAP related severity and outcome TBI, multiple trauma without TBI. Methods: prospective enrolled 114 patients who had TBI with or (n = 101) 13), as verified by computerized tomography. Daily measurement began at admission (<12 hours trauma) continued for the duration of intensive care (1–22 days). Documentation included categorization tomography according...
Objective To evaluate the posttraumatic course of several inflammatory mediators or markers (complement components C3, C3a, terminal complement complex, thromboxane B2, C-reactive protein, elastase, and neopterin) in relation to development multiple organ failure mortality. Design Prospective study a selected patient group. Setting Surgical intensive care units three European trauma hospitals. Patients (n = 56) with severe blunt (Injury Severity Score >or=to33). Interventions Arterial blood...
Application of 4-(aminomethyl)cyclohexanecarboxylic acid (tranexamic acid; TAMCA) to the central nervous system (CNS) has been shown result in hyperexcitability and convulsions. However, mechanisms underlying this action are unknown. In present study, we demonstrate that TAMCA binds gamma-aminobutyric (GABA) binding site GABA(A) receptors membranes from rat cerebral cortex does not interfere with N-methyl-D-aspartate receptors. Patch-clamp studies using human embryonic kidney cells...
Abstract For almost 30 years, extracorporeal shock wave therapy has been clinically implemented as an effective treatment to disintegrate urinary stones. This technology also emerged noninvasive modality for several orthopedic and traumatic indications including problematic soft tissue wounds. Delayed/nonhealing or chronic wounds constitute a burden each patient affected, significantly impairing quality of life. Intensive wound care is required, this places enormous on society in terms lost...
The umbilical cord and placenta are extra-embryonic tissues of particular interest for regenerative medicine. They share an early developmental origin a source vast amounts cells with multilineage differentiation potential that poorly immunogenic without controversy. Moreover, these likely exempt from incorporated mutations when compared juvenile or adult donor such as skin fibroblasts keratinocytes. Here we report the efficient generation induced pluripotent stem (iPSCs) mesenchymal matrix...
In the past decade, adipose tissue became a highly interesting source of adult stem cells for plastic surgery and regenerative medicine. The isolated stromal vascular fraction (SVF) is heterogeneous cell population including adipose-derived stromal/stem (ASC), which showed potential in several clinical studies trials. SVF should be provided safe reproducible manner accordance with current good manufacturing practices (cGMP). To ensure highest possible safety patients, precisely defined...