A5031609785- Electrospun Nanofibers in Biomedical Applications
- Tissue Engineering and Regenerative Medicine
- Silk-based biomaterials and applications
- Knee injuries and reconstruction techniques
- European history and politics
- Infectious Aortic and Vascular Conditions
- Aortic Disease and Treatment Approaches
- 3D Printing in Biomedical Research
- Bone Tissue Engineering Materials
- Economic and Social Issues
- Ecology, Conservation, and Geographical Studies
- Total Knee Arthroplasty Outcomes
- Polymer Surface Interaction Studies
- MicroRNA in disease regulation
- Libraries and Information Services
- Mesenchymal stem cell research
- Advanced Sensor and Energy Harvesting Materials
- Extracellular vesicles in disease
- Graphene and Nanomaterials Applications
- Collagen: Extraction and Characterization
- Biomarkers in Disease Mechanisms
- Bone and Dental Protein Studies
- Reconstructive Surgery and Microvascular Techniques
- Dyeing and Modifying Textile Fibers
- Angiogenesis and VEGF in Cancer
Medical University of Vienna
2017-2025
Austrian Cluster for Tissue Regeneration
2015-2025
Ludwig Boltzmann Institute for Digital Health and Prevention
2020-2024
Ludwig Boltzmann Institute for Cancer Research
2020-2024
Tufts University
2023
Ludwig Boltzmann Cluster for Cardiovascular Research
2017-2019
Ludwig Boltzmann Institute for Experimental and Clinical Traumatology
2014-2016
BOKU University
2016
Damage to cells and tissues is one of the driving forces aging age-related diseases. Various repair systems are in place counteract this functional decline. In particular, property adult stem self-renew differentiate essential for tissue homeostasis regeneration. However, their functionality declines with age (Rando, 2006). One organ that notably affected by reduced differentiation capacity skeleton. Here, we found circulating microvesicles impact on osteogenic mesenchymal a...
BACKGROUND: Venous thromboembolism is a major health problem. After thrombus formation, its resolution essential to re-establish blood flow, which crucially mediated by infiltrating neutrophils and monocytes in concert with activated platelets endothelial cells. Thus, we aimed modulate leukocyte function during post-thrombus formation blocking P-selectin/CD62P-mediated cell interactions. METHODS: Thrombosis was induced inferior vena cava stenosis through ligation mice. 1 day,...
The human meniscus transmits high axial loads through the knee joint. This function is compromised upon injury or treatment by meniscectomy. 3D printing of implants has emerged as a promising alternative treatment, it allows for precise mimicry architecture. In this study, silk fibroin (SF) known its excellent mechanical properties used to fabricate hydrogels bioprinting with infrapatellar fat pad-derived mesenchymal stem cells (IFP-MSCs). Extracellular matrix (ECM) derived from bovine...
There is a great clinical need and it remains challenge to develop artificial soft tissue constructs that can mimic the biomechanical properties bioactivity of natural tissue. This partly due lack suitable biomaterials. Hydrogels made from human placenta offer high represent potential solution create animal-free 3D bioprinting systems are both sustainable acceptable, as widely considered medical waste. A combination with silk gelatin polymers bridge limitations chorion extracellular matrix...
The present study describes a silk microfiber reinforced meniscus scaffold (SMRMS) with hierarchical fibrous and porous structure made from fibroin (SF) wool keratin (WK) using electrospinning freeze-drying technology. This focuses on the morphology, secondary structure, mechanical properties, water absorption properties of scaffold. cytotoxicity biocompatibility SMRMS are assessed in vivo vitro. shows pore size distribution (ranges 50 to 650 µm), robust (compression strength can reach at...
Clinically available small-diameter synthetic vascular grafts (SDVGs) have unsatisfactory patency rates due to impaired graft healing. Therefore, autologous implants are still the gold standard for small vessel replacement. Bioresorbable SDVGs may be an alternative, but many polymers inadequate biomechanical properties that lead failure. To overcome these limitations, a new biodegradable SDVG is developed ensure safe use until adequate tissue formed. electrospun using polymer blend composed...
Due to its high printing resolution and ability print multiple materials simultaneously, inkjet technology has found wide application in medicine. However, the biological safety of 3D-printed objects is not always guaranteed due residues uncured resins or support must therefore be verified. The aim this study was evaluate quality standard assessment methods for determining properties polyjet-printed scaffolds terms their dimensional accuracy, surface topography, cytotoxic...
Incorporation of oxidized graphene improves pHEMA's mechanical properties enabling its application as bulk material in the design blood-contacting devices. These composites keep biological properties, preventing thrombosis and infection.
Cardiac tissue engineering faces a great challenge to construct cell-inductive scaffold encouraging the proliferation of cardiac-specific host cells for effective myocardium repair. 3D printing allows precise fabrication intricate structures like cardiac patches but produces large pores (sub-macron), reducing surface area cell attachment and regeneration. Moreover, hydrophobic nature most polyesters used in further complicates adhesion integration. In this study, human chorion placenta...
We designed and tested an experimental setup intended for medical device quality assurance, capable of multimodal loading fiber-based magnetic scaffolds. These scaffolds are promising hyperthermia treatment hollow organ cancers. To approximate the physiological conditions during treatment, a load consisting thermal load, hydrodynamic mechanical was considered. The effect on polypropylene fibers with embedded nanoparticles analyzed to assess changes in properties fibers. demonstrate that...
Vascular grafts with a diameter of less than 6 mm are made from variety materials and techniques to provide alternatives autologous vascular grafts. Decellularized have been proposed as possible approach create extracellular matrix (ECM) prostheses they naturally derived inherently support various cell functions. However, these desirable graft characteristics may be limited by alterations the ECM during decellularization process leading decreased biomechanical properties hemocompatibility....
Currently available synthetic small diameter vascular grafts reveal low patency rates due to thrombosis and intimal hyperplasia. Biofunctionalized releasing nitric oxide (NO) in situ may overcome these limitations. In this study, a drug-eluting graft was designed by blending polycaprolactone (PCL) with S-nitroso-human-serum-albumin (S-NO-HSA), donor prolonged half-life. PCL-S-NO-HSA patches were fabricated via electrospinning. The fabrication process optimized. Patches characterized vitro...
In-stent restenosis caused by tumor ingrowth increases the risk of secondary surgery for patients with abdominal aortic aneurysms (AAA) because conventional vascular stent grafts suffer from mechanical fatigue, thrombosis, and endothelial hyperplasia. For that, we report a woven stent-graft robust properties, biocompatibility, drug delivery functions to inhibit thrombosis growth AAA. Paclitaxel (PTX)/metformin (MET)-loaded silk fibroin (SF) microspheres were self-assembly synthesized...
The endothelium plays an important regulatory role for cardiovascular homeostasis. Rapid endothelialization of small diameter vascular grafts (SDVGs) is crucial to ensure long-term patency. Here, we assessed a human placental chorionic extracellular matrix hydrogel (hpcECM-gel) as coating material and compared it fibronectin in-vitro. hpcECM-gels were produced from chorion by decellularization enzymatic digestion. Human umbilical vein endothelial cells (HUVECs) seeded non-, fibronectin- or...
The lack of small-diameter vascular grafts (inner diameter <5 mm) to substitute autologous in arterial bypass surgeries has a massive impact on the prognosis and progression cardiovascular diseases, leading cause death globally. Decellularized arteries from different sources have been proposed as an alternative, but their poor mechanical performance high collagen exposure, which promotes platelet bacteria adhesion, limit successful application. In this study, these limitations were surpassed...
Abstract Decellularized matrices offer a beneficial substitute for biomimetic scaffolds in tissue engineering. The current study examines the potential of decellularized placental vessel sleeves (PVS) as periosteal protective sleeve to enhance bone regeneration embryonic day 18 chick femurs contained within PVS and cultured organotypically over 10 period. are inserted into biocompatibility‐tested maintained an organotypic culture period days. In containing PVS, significant increase volume (...
Pepsin-solubilized atelocollagen can be used to form highly complex three-dimensional matrices for a broad spectrum of tissue engineering applications. Moreover, it has long history as favorable biomaterial in pharmaceutical and medical industries. So far, the main sources these approaches are collagens from xenogenic sources. Yet, nonhuman carry risk provoking immune reactions patients. Here we describe an effective method isolating type 1/3 (COL1/3) human placenta. By combining single...
In this study, we aimed to evaluate the human placenta as a source of blood vessels that can be harvested for vascular graft fabrication in submillimeter range. Our approach included modification prevent thrombotic events. Submillimeter arterial grafts from were decellularized and chemically crosslinked heparin. Graft performance was evaluated using microsurgical arteriovenous loop (AVL) model Lewis rats. Specimens through hematoxylin-eosin CD31 staining histological sections analyze host...
Introduction: Free flap-based soft tissue reconstruction comes at the price of donor-site morbidity. Providing an opportunity to overcome this issue, arteriovenous loop (AVL) technique allows for de novo generation axially vascularized flaps from vein grafts embedded into different matrices. Thus far, application AVL has been limited by insufficient long-term volume retention and poor stability. Therefore, we investigated suitability a novel human dermal scaffold improve Methods: AVLs were...