A5100403902- Silk-based biomaterials and applications
- Electrospun Nanofibers in Biomedical Applications
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Bone Tissue Engineering Materials
- Biochemical and Structural Characterization
- Polymer Surface Interaction Studies
- Dyeing and Modifying Textile Fibers
- Surface Modification and Superhydrophobicity
- RNA Interference and Gene Delivery
- Advanced Sensor and Energy Harvesting Materials
- Advanced Nanomaterials in Catalysis
- Wound Healing and Treatments
- Silkworms and Sericulture Research
- Surgical Sutures and Adhesives
- Nerve injury and regeneration
- Vacuum and Plasma Arcs
- Antimicrobial Peptides and Activities
- Nanoparticle-Based Drug Delivery
- Advanced Photocatalysis Techniques
- Sleep and Work-Related Fatigue
- Phytochemical compounds biological activities
- Viral gastroenteritis research and epidemiology
- Mind wandering and attention
- Carbon Dioxide Capture Technologies
Soochow University
2016-2025
Southwest Petroleum University
2024-2025
National Institute of Fashion Technology
2025
Southwest University
2023-2024
First Affiliated Hospital of Xi'an Jiaotong University
2024
Beibu Gulf University
2024
University of Waterloo
2024
Fudan University
2023
Lanzhou Jiaotong University
2023
Guangdong University of Technology
2017-2023
Abstract Silk/polyethylene glycol (PEG) hydrogels are studied as self‐standing bioinks for 3D printing tissue engineering. The two components of the bioink, silk fibroin protein (silk) and PEG, both Food Drug Administration approved materials in drug medical device products. Mixing PEG with induces β‐sheet structure formation thus gelation water insolubility due to physical crosslinking. A variety constructs high resolution, shape fidelity, homogeneous gel matrices printed. When human bone...
Spider silks are among the toughest known materials and thus provide models for renewable, biodegradable, sustainable biopolymers. However, entirety of their diversity still remains elusive, that exceed performance limits industrial fibers constantly being found. We obtained transcriptome assemblies from 1098 species spiders to comprehensively catalog silk gene sequences measured mechanical, thermal, structural, hydration properties dragline 446 species. The combination these protein...
Wound dressings are important for wound repair. The morphology of the biomaterials used in these dressings, and particular, pore structure affects tissue regeneration by facilitating attachment proliferation cells due to hierarchical multiscale, water absorbance, nutrient transport. In present study, silk fibroin (SF) sponges with walls containing nanopores (SFNS) were prepared from SF nanoparticles generated during autoclaving solutions, followed leaching freeze-dried SF. nano/microporous...
We directly prepared insoluble silk films by blending with glycerol and avoiding the use of organic solvents. The ability to blend a plasticizer like hydrophobic protein achieve stable material systems above critical threshold is an important new finding importance for green chemistry approaches more flexible silk-based biomaterials. aqueous solubility, biocompatibility, well-documented as other biopolymers prompted its inclusion in fibroin solutions assess impact on film behavior....
Material systems are needed that promote stabilization of entrained molecules, such as enzymes or therapeutic proteins, without destroying their activity. We demonstrate the unique structure silk fibroin protein, when assembled into solid state, establishes an environment is conducive to proteins. Enzymes (glucose oxidase, lipase, and horseradish peroxidase) entrapped in these films over 10 months retained significant activity, even stored at 37 °C, case glucose oxidase did not lose any...
We report formation of biocompatible hydrogels using physically cross-linked biopolymers. Gelation silk fibroin (from B. mori silkworm) aqueous solution was effected by ultrasonication and used to entrap blended, un-cross-linked, hyaluronic acid (HA) without chemical cross-linking. HA formed into silk/HA blended with different mixing ratios, forming homogeneous materials stable swelling behavior when the content less than 40 wt %. This is a novel approach hydrogel systems, which otherwise...
Abstract Cartilage tissue engineering based on cultivation of immature chondrocytes in agarose hydrogel can yield constructs with biomechanical properties comparable to native cartilage. However, is immunogenic and nondegradable, our capability modify the structure, composition, mechanical this material rather limited. In contrast, silk biocompatible biodegradable, it be produced using a water‐based method without organic solvents that enables precise control structural range interest for...
Biomedical textiles and fiber‐based implants (BTFIs) have been in routine clinical use to facilitate healing for nearly five decades. Amongst the variety of biomaterials used, silk‐based (SBBs) widely used clinically viz. sutures centuries are being increasingly recognized as a prospective material biomedical textiles. The ease processing, controllable degradability, remarkable mechanical properties biocompatibility prompted SBBs various BTFIs extracorporeal implants, soft tissue repair,...
Abstract A significant challenge remains to protect protein drugs from inactivation during production, storage, and use. In the present study, stabilization release of horseradish peroxidase (HRP) in silk films was investigated. Water‐insoluble were prepared under mild aqueous conditions, maintaining activity entrapped enzyme. Depending on film processing post‐processing HRP retained more than 90% initial at 4 °C, room temperature 37 °C over two months. The stability is attributed...
A method was developed to fabricate light, water-insoluble silk fibroin nanofibrous aerogels (SNFAs) through solvent welding of lyophilized 3D networks at the junction points while converting structures from random-coils β-sheets (water insoluble). Aromatic alcohols, especially phenethyl alcohol (PEA), supported robust and structural conversion silk. PEA vapor treatment a better approach than infusion retain volume, density, mechanical strength SNFAs. The properties highly orientated SNFAs...