W. Joost Wiersinga
A5030071794- Sepsis Diagnosis and Treatment
- Burkholderia infections and melioidosis
- COVID-19 Clinical Research Studies
- Gut microbiota and health
- Clostridium difficile and Clostridium perfringens research
- Immune Response and Inflammation
- SARS-CoV-2 and COVID-19 Research
- Long-Term Effects of COVID-19
- Bacterial Identification and Susceptibility Testing
- Intensive Care Unit Cognitive Disorders
- Nosocomial Infections in ICU
- Pneumonia and Respiratory Infections
- Streptococcal Infections and Treatments
- Respiratory viral infections research
- Respiratory Support and Mechanisms
- HIV/AIDS Research and Interventions
- Antibiotic Use and Resistance
- Pancreatitis Pathology and Treatment
- Thermal Regulation in Medicine
- Viral gastroenteritis research and epidemiology
- COVID-19 and healthcare impacts
- Inflammation biomarkers and pathways
- HIV-related health complications and treatments
- Salmonella and Campylobacter epidemiology
- HIV/AIDS drug development and treatment
Amsterdam University Medical Centers
2018-2025
University of Amsterdam
2016-2025
Amsterdam UMC Location University of Amsterdam
2015-2025
University Medical Center
2019-2025
Institute of Infection and Immunity
2007-2025
Center for Molecular Medicine and Immunology
2007-2023
GGD Amsterdam
2023
Geneeskundige en Gezondheidsdienst
2005-2023
Office of Infectious Diseases
2002-2022
Amsterdam Neuroscience
2021
Objective: To provide an update to “Surviving Sepsis Campaign Guidelines for Management of and Septic Shock: 2012.” Design: A consensus committee 55 international experts representing 25 organizations was convened. Nominal groups were assembled at key meetings (for those members attending the conference). formal conflict-of-interest (COI) policy developed onset process enforced throughout. stand-alone meeting held all panel in December 2015. Teleconferences electronic-based discussion among...
INTRODUCTION Sepsis is life-threatening organ dysfunction caused by a dysregulated host response to infection (1). and septic shock are major healthcare problems, impacting millions of people around the world each year killing between one in three six those it affects (2–4). Early identification appropriate management initial hours after development sepsis improve outcomes. The recommendations this document intended provide guidance for clinician caring adult patients with or hospital...
Sites of vulnerability in SARS-CoV-2 Antibodies that neutralize severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) could be an important tool treating disease 2019 (COVID-19). Brouwer et al. isolated 403 monoclonal antibodies from three convalescent COVID-19 patients. They show the patients had strong immune responses against viral spike protein, a complex binds to receptors on host cell. A subset was able virus. Competition and electron microscopy studies showed these target...
Human immunodeficiency virus (HIV)-infected individuals may be at increased risk of age-associated noncommunicable comorbidities (AANCCs).Cross-sectional analyses AANCC prevalence (including cardiovascular, metabolic, pulmonary, renal, bone, and malignant disease) factors in a prospective cohort study HIV type 1-infected HIV-uninfected controls, who were aged ≥45 years comparable regarding most lifestyle demographic factors.HIV-infected participants (n = 540) had significantly higher mean...
<h3>Objective</h3> Pneumonia accounts for more deaths than any other infectious disease worldwide. The intestinal microbiota supports local mucosal immunity and is increasingly recognised as an important modulator of the systemic immune system. precise role gut in bacterial pneumonia, however, unknown. Here, we investigate function host defence against <i>Streptococcus pneumoniae</i> infections. <h3>Design</h3> We depleted C57BL/6 mice subsequently infected them intranasally with <i>S....
The Surviving Sepsis Campaign (SSC) International Guidelines for the Management of and Septic Shock provide guidance on care hospitalized adult patients with (or at risk for) sepsis, based systematic summary assessment relevant literature. This executive reviews history, scope, methodology, major recommendations guidelines, focusing aspects that are new or different compared 2016 guidelines were published in 2017. Full description process provided complete document. HISTORY AND SCOPE OF THE...
Immunoglobulin G (IgG) antibodies are crucial for protection against invading pathogens. A highly conserved N-linked glycan within the IgG-Fc tail, which is essential IgG function, shows variable composition in humans. Afucosylated variants already used anticancer therapeutic their increased activity through Fc receptors (FcγRIIIa). Here, we report that afucosylated (approximately 6% of total humans) specifically formed enveloped viruses but generally not other antigens. This mediates...
Rotavirus (RV) is the leading cause of diarrhea-related death in children worldwide and 95% RV-associated deaths occur Africa Asia where RV vaccines (RVVs) have lower efficacy. We hypothesize that differences intestinal microbiome composition correlate with decreased RVV efficacy observed poor settings. conducted a nested, case-control study comparing prevaccination, fecal compositions between 6-week old, matched responders nonresponders rural Ghana. These infants' microbiomes were then...
The intestinal microbiota has emerged as a virtual organ with essential functions in human physiology. Antibiotic-induced disruption of the critically ill patients may have negative influence on key energy resources and immunity. We set out to characterize fecal composition both without sepsis explore use microbiota-derived markers for clinical outcome measurements this setting. In prospective observational cohort study we analyzed 34 admitted intensive care unit. Fifteen healthy subjects...
ABSTRACT Preclinical animal studies precede the majority of clinical trials. While definitions sepsis and recommended treatments are regularly updated, a systematic review preclinical models has not been done clear modeling guidelines lacking. To address this deficit, Wiggers-Bernard Conference on was held in Vienna May, 2017. The goal conference to identify limitations propose set guidelines, defined as “ Minimum Quality Threshold Sepsis Studies ” (MQTiPSS), enhance translational value...