Marije K. Bomers
A5024082861- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- HIV/AIDS drug development and treatment
- HIV/AIDS Research and Interventions
- Clostridium difficile and Clostridium perfringens research
- Animal Virus Infections Studies
- SARS-CoV-2 detection and testing
- Neutropenia and Cancer Infections
- Hepatitis C virus research
- Sepsis Diagnosis and Treatment
- Diabetes and associated disorders
- Bacterial Identification and Susceptibility Testing
- Hepatitis B Virus Studies
- Monoclonal and Polyclonal Antibodies Research
- Advanced Chemical Sensor Technologies
- Antibiotic Resistance in Bacteria
- Olfactory and Sensory Function Studies
- HIV Research and Treatment
- Respiratory viral infections research
- HIV, Drug Use, Sexual Risk
- T-cell and B-cell Immunology
- Liver Disease Diagnosis and Treatment
- Microscopic Colitis
- HIV-related health complications and treatments
Amsterdam University Medical Centers
2019-2024
Vrije Universiteit Amsterdam
2015-2024
University of Amsterdam
2020-2024
Stichting HIV Monitoring
2023
Public Health Service of Amsterdam
2023
Amsterdam UMC Location Vrije Universiteit Amsterdam
2010-2022
Institute of Infection and Immunity
2021-2022
Inserm
2021
Aidsfonds
2021
Corvid Technologies (United States)
2020
Immunoglobulin G (IgG) antibodies are crucial for protection against invading pathogens. A highly conserved N-linked glycan within the IgG-Fc tail, which is essential IgG function, shows variable composition in humans. Afucosylated variants already used anticancer therapeutic their increased activity through Fc receptors (FcγRIIIa). Here, we report that afucosylated (approximately 6% of total humans) specifically formed enveloped viruses but generally not other antigens. This mediates...
BackgroundMortality rates are high among hospitalized patients with COVID-19, especially in those intubated on the ICU. Insight pathways associated unfavourable outcome may lead to new treatment strategies.MethodsWe performed a prospective cohort study of COVID-19 admitted general ward or ICU who underwent serial blood sampling. To provide insight involved disease progression, associations were estimated between risk and measurements 64 biomarkers potential important infection (inflammation,...
Emerging and future SARS-CoV-2 variants may jeopardize the effectiveness of vaccination campaigns. Therefore, it is important to know how different vaccines perform against diverse variants.
Large-scale vaccination campaigns have prevented countless hospitalizations and deaths due to COVID-19. However, the emergence of SARS-CoV-2 variants that escape from immunity challenges effectiveness current vaccines. Given this continuing evolution, an important question is when how update vaccines antigenically match circulating variants, similarly seasonal influenza viruses where antigenic drift necessitates periodic vaccine updates. Here, we studied by assessing neutralizing activity...
<b>Objective</b> To investigate whether a dog’s superior olfactory sensitivity can be used to detect <i>Clostridium difficile</i> in stool samples and hospital patients. <b>Design</b> Proof of principle study, using case-control design. <b>Setting</b> Two large Dutch teaching hospitals. <b>Participants</b> A 2 year old beagle trained identify the smell <i>C tested on 300 patients (30 with infection 270 controls). <b>Intervention</b> The dog was guided along wards by its trainer, who blinded...
Antibodies of convalescent COVID-19 patients and vaccine recipients show reduced recognition SARS-CoV-2 variants concern.
Abstract Severe acute respiratory syndrome coronavirus (SARS-CoV)-2 infections often cause only mild disease that may evoke relatively low Ab titers compared with patients admitted to hospitals. Generally, total bridging assays combine good sensitivity high specificity. Therefore, we developed sensitive for detection of SARS-CoV-2 Abs the receptor-binding domain (RBD) and nucleocapsid protein in addition conventional isotype-specific assays. kinetics was assessed PCR-confirmed, hospitalized...
Current SARS-CoV-2 vaccines are losing efficacy against emerging variants and may not protect future novel coronavirus outbreaks, emphasizing the need for more broadly protective vaccines. To inform development of a pan-coronavirus vaccine, we investigated presence specificity cross-reactive antibodies spike (S) proteins human coronaviruses (hCoV) after infection vaccination. We found an 11- to 123-fold increase in binding SARS-CoV MERS-CoV as well 2- 4-fold difference seasonal hCoVs...
Summary Large-scale vaccination campaigns have prevented countless hospitalizations and deaths due to COVID-19. However, the emergence of SARS-CoV-2 variants that escape from immunity challenges effectiveness current vaccines. Given this continuing evolution, an important question is when how update vaccines antigenically match circulating variants, similar seasonal influenza viruses where antigenic drift necessitates periodic vaccine updates. Here, we studied by assessing neutralizing...
Rationale: Bacterial lung microbiota are correlated with inflammation and acute respiratory distress syndrome (ARDS) altered in severe coronavirus disease (COVID-19). However, the association between (including fungi) resolution of ARDS COVID-19 remains unclear. We hypothesized that increased bacterial fungal burdens related to nonresolving mortality COVID-19. Objectives: To determine relation clinical outcomes COVID-19–related ARDS. Methods: This observational cohort study enrolled...
Abstract SARS-CoV-2 infections worldwide led to a surge in cases of Long COVID, post-infectious syndrome. It has been hypothesized that autoantibodies play crucial role the development COVID and other syndromes, such as fibromyalgia myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). In this study, we tested hypothesis by passively transferring total IgG from patients mice. Using Glial Fibrillary Acidic Protein (GFAP) type-I interferon expression, stratified into three subgroups,...
Abstract Background Health-related quality of life (HRQoL) data post–COVID-19 in patients with medical conditions associated severe disease are lacking. Here, we assess the longitudinal impact COVID-19 on HRQoL and employment status individuals at high risk. Methods This multicenter prospective cohort study included risk for who were hospitalized or not-hospitalized SARS-CoV-2 infection (September 2021–February 2024). Questionnaires about collected 3, 6, 12 months retrospectively recalled...
<h3>Importance</h3> It is unclear when, where, and by whom health care workers (HCWs) working in hospitals are infected with SARS-CoV-2. <h3>Objective</h3> To determine how often what manner nosocomial SARS-CoV-2 infection occurs HCW groups varying exposure to patients COVID-19. <h3>Design, Setting, Participants</h3> This cohort study comprised 4 weekly measurements of SARS-CoV-2–specific antibodies collection questionnaires from March 23 June 25, 2020, combined phylogenetic epidemiologic...
Afucosylated IgG1 responses have only been found against membrane-embedded epitopes, including anti-S in SARS-CoV-2 infections. These responses, intrinsically protective through enhanced FcγRIIIa binding, can also trigger exacerbated pro-inflammatory severe COVID-19. We investigated if the BNT162b2 mRNA induced afucosylated IgG responses.Blood from vaccinees during first vaccination wave was collected. Liquid chromatography-Mass spectrometry (LC-MS) used to study Fc glycoprofiles....
BackgroundPost-acute sequela of SARS-CoV-2 infection (PASC) encompass fatigue, post-exertional malaise and cognitive problems. The abundant expression the tryptophan-catabolizing enzyme indoleamine 2,3-dioxygenase-2 (IDO2) in fatal/severe COVID-19, led us to determine, an exploratory observational study, whether IDO2 is expressed active PASC, may correlate with pathophysiology.MethodsPlasma or serum, peripheral blood mononuclear cells (PBMC) were obtained from well-characterized PASC...
Background Chest CT displays chest pathology better than X-ray (CXR). We evaluated the effects on health outcomes of replacing CXR by ultra-low-dose chest-CT (ULDCT) in diagnostic work-up patients suspected non-traumatic pulmonary disease at emergency department. Methods Pragmatic, multicentre, non-inferiority randomised clinical trial Between 31 January 2017 and May 2018, every month, participating centres were randomly allocated to using ULDCT or CXR. Primary outcome was functional 28...
Background Coronavirus disease 2019 (COVID-19)-induced mortality occurs predominantly in older patients. Several immunomodulating therapies seem less beneficial these The biological substrate behind observations is unknown. aim of this study was to obtain insight into the association between ageing, host response and patients with COVID-19. Methods We determined 43 biomarkers reflective alterations four pathophysiological domains: endothelial cell coagulation activation, inflammation organ...
IgG antibodies are important mediators of vaccine-induced immunity through complement- and Fc receptor-dependent effector functions. Both influenced by the composition conserved N-linked glycan located in domain. Here, we compared anti-Spike (S) IgG1 glycosylation profiles response to mRNA, adenoviral, protein-based COVID-19 vaccines mass spectrometry (MS). All induced a transient increase antigen-specific galactosylation sialylation. An initial, afucosylated was membrane-encoding S protein...
Inflammatory bowel disease (IBD), including Crohn's (CD) and ulcerative colitis (UC), remains challenging to diagnose. Diagnostic work-up carries a high burden, especially in paediatric patients, due invasive endoscopic procedures. IBD is associated with alterations intestinal microbiota composition. Faecal volatile organic compounds (VOCs) reflect gut The aim of this study was assess the diagnostic accuracy faecal VOC profiling as non-invasive biomarker for IBD.In performed two tertiary...
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