A5022073275- Cardiac Arrest and Resuscitation
- Animal Virus Infections Studies
- Long-Term Effects of COVID-19
- SARS-CoV-2 and COVID-19 Research
- Cardiac Imaging and Diagnostics
- Acute Myocardial Infarction Research
- Cardiac electrophysiology and arrhythmias
- Intensive Care Unit Cognitive Disorders
- Heart Rate Variability and Autonomic Control
- COVID-19 Clinical Research Studies
- ECG Monitoring and Analysis
- Mechanical Circulatory Support Devices
- Trauma and Emergency Care Studies
- Cardiac Structural Anomalies and Repair
- COVID-19 and Mental Health
- Life Cycle Costing Analysis
- Viral Infections and Immunology Research
- Cardiac Health and Mental Health
- Traumatic Brain Injury Research
- Respiratory Support and Mechanisms
- Cardiovascular Effects of Exercise
- Sepsis Diagnosis and Treatment
- Cardiovascular Function and Risk Factors
- Climate Change Policy and Economics
- vaccines and immunoinformatics approaches
University of Amsterdam
2021-2024
Amsterdam University Medical Centers
2021-2024
Institute of Infection and Immunity
2021-2023
Amsterdam UMC Location University of Amsterdam
2023
Current SARS-CoV-2 vaccines are losing efficacy against emerging variants and may not protect future novel coronavirus outbreaks, emphasizing the need for more broadly protective vaccines. To inform development of a pan-coronavirus vaccine, we investigated presence specificity cross-reactive antibodies spike (S) proteins human coronaviruses (hCoV) after infection vaccination. We found an 11- to 123-fold increase in binding SARS-CoV MERS-CoV as well 2- 4-fold difference seasonal hCoVs...
BACKGROUND: In patients with out-of-hospital cardiac arrest who present an initial shockable rhythm, a longer delay to the first shock decreases probability of survival, often attributed cerebral damage. The mechanisms this decreased survival have not yet been elucidated. Estimating successful defibrillation and other factors in relation time may guide prehospital care systems implement policies that improve patient by decreasing shock. METHODS: Patients witnessed ventricular fibrillation...
Abstract Background Currently, there is limited evidence about the long-term impact on physical, social and emotional functioning, i.e. health-related quality of life (HRQL) after mild or moderate COVID-19 not requiring hospitalization. We compared HRQL among persons with initial mild, severe/critical at 1 12 months following illness onset Dutch population norms investigated restrictive public health control measures HRQL. Methods RECoVERED, a prospective cohort study in Amsterdam,...
There is increasing data that show a persistently impaired pulmonary function upon recovery after severe infection. Little known however about the extent, and determinants of impairment across full spectrum COVID-19 severity over time.In well characterized, prospective cohort both hospitalised non-hospitalised individuals with SARS-CoV-2 infection, RECoVERED study, (diffusing capacity for carbon monoxide (DLCO)) spirometry) was measured until one year disease onset. Additionally, on...
The urgent need for, but limited availability of, SARS-CoV-2 vaccines worldwide has led to widespread consideration of dose-sparing strategies. Here, we evaluate the SARS-CoV-2-specific antibody responses following BNT162b2 vaccination in 150 previously SARS-CoV-2-infected individuals from a population-based cohort. One week after first vaccine dose, spike protein levels are 27-fold higher and neutralizing titers 12-fold higher, exceeding fully vaccinated SARS-CoV-2-naive controls, with...
Background: This longitudinal study evaluates the extent of impaired pulmonary function over time after SARS-CoV-2 infection across full spectrum COVID-19 severity.Methods: Pulmonary was measured by diffusing capacity for carbon monoxide (DLCO) at one, six, and twelve months illness onset. Additionally, data on sociodemographics, clinical characteristics, symptoms, health-related quality life (HRQL) were collected. determinants modelled using mixed-effect linear regression. Determinants...
Abstract Sudden cardiac arrest (SCA) studies are often population-based, limited to sudden death, and excluding infants. To guide prevention opportunities, it is essential be informed of pediatric SCA etiologies. Unfortunately, etiologies frequently remain unresolved. The objectives this study were determine paediatric etiology, evaluate the extent post-SCA investigations assess performance previous evaluation in detecting conditions predisposing SCA. In a retrospective cohort (2002–2019),...
Abstract Current SARS-CoV-2 vaccines are losing efficacy against emerging variants and may not protect future novel coronavirus outbreaks, emphasizing the need for more broadly protective vaccines. To inform development of a pan-coronavirus vaccine, we investigated presence specificity cross-reactive antibodies spike (S) proteins human coronaviruses (hCoV) after infection vaccination. We found an 11 to 123-fold increase in binding SARS-CoV MERS-CoV as well 2 4-fold difference seasonal hCoVs...
Introduction: Refractory VF, pragmatically defined as a shockable presenting rhythm that is still observed after three shocks and associated 2-minute CPR cycles, often encountered in out-of-hospital cardiac arrest (OHCA) with worse outcomes. A recent clinical trial tested alternative strategies for treating patients meeting this definition of refractory VF. It unknown how standard defibrillation truly fails to terminate VF these patients. Methods: Using the prospective AmsteRdam...
Introduction: In OHCA patients with an initial shockable rhythm, a longer time interval between onset of VF and the first shock decreases likelihood survival. The exact mechanism to explain this decrease is not clear. We investigated delay outcomes termination, return organized rhythm (ROOR), ROSC Methods: studied witnessed as using prospective ARREST registry. Patient- resuscitation data, including time-synchronized AED manual defibrillator were analysed determine termination at 5 seconds...
Introduction: High Sense-Troponin T (HS-TnT) is a key determinant for presence or absence of acute MI in chest pain patients (pts). Its value diagnosis pts with out-of-hospital cardiac arrest (OHCA) needs assessment because myocardial ischemia may be the cause but also consequence causing global during no and low flow periods. Methods: Data were prospectively collected. From included ARREST registry who survived OHCA to discharge VF as initial rhythm, peak HS-TnT analyzed. Cause was...