Colette Smit
A5037944984- Hepatitis C virus research
- HIV/AIDS Research and Interventions
- HIV/AIDS drug development and treatment
- Hepatitis B Virus Studies
- HIV-related health complications and treatments
- Liver Disease Diagnosis and Treatment
- HIV Research and Treatment
- HIV, Drug Use, Sexual Risk
- Syphilis Diagnosis and Treatment
- Viral-associated cancers and disorders
- Pneumocystis jirovecii pneumonia detection and treatment
- Cervical Cancer and HPV Research
- Liver physiology and pathology
- Systemic Lupus Erythematosus Research
- Herpesvirus Infections and Treatments
- Venous Thromboembolism Diagnosis and Management
- Blood groups and transfusion
- Bacillus and Francisella bacterial research
- Food Allergy and Anaphylaxis Research
- Proteoglycans and glycosaminoglycans research
- Liver Disease and Transplantation
- Drug-Induced Hepatotoxicity and Protection
- Autoimmune and Inflammatory Disorders
- Peripheral Artery Disease Management
- Gestational Diabetes Research and Management
Stichting HIV Monitoring
2015-2025
Public Health Service of Amsterdam
2006-2023
Amsterdam UMC Location University of Amsterdam
1997-2016
University of Amsterdam
1997-2016
Amsterdam Institute for Global Health and Development
2016
University of Modena and Reggio Emilia
2009
Maastricht University Medical Centre
2008
National Institute of Public Health
2002
ABSTRACT Objectives To investigate the impact of harm‐reduction programmes on HIV and hepatitis C virus (HCV) incidence among ever‐injecting drug users (DU) from Amsterdam Cohort Studies (ACS). Methods The association between use harm reduction seroconversion for human immunodeficiency (HIV) and/or was evaluated using Poisson regression. A total 714 DU were at risk HCV during follow‐up. Harm measured by combining its two most important components—methadone dose needle exchange programme...
Background. Since 2000, incidence of sexually acquired hepatitis C virus (HCV)-infection has increased among human immunodeficiency (HIV)-infected men who have sex with (MSM). To date, few case-control and cohort studies evaluating HCV transmission risk factors were conducted in this population, most these initially designed to study HIV-related behavior characteristics. Methods. From 2009 onwards, HIV-infected MSM acute infection controls (HIV-monoinfected MSM) prospectively included the...
Purpose In 1998, the AIDS Therapy Evaluation in Netherlands (ATHENA) national observational HIV cohort was established to demonstrate lifesaving effectiveness of triple combination antiretroviral therapy, including HIV-protease inhibitors, that had recently been made available for clinical use. Subsequently, Monitoring Foundation by Dutch Ministry Health, Welfare and Sport continue ATHENA as an open order registration monitoring all HIV-positive people integral part care 26 treatment centres...
Background Since 2009, European guidelines recommend individuals with hepatitis B virus (HBV) and HIV be tested for D (HDV). Aim To analyse HDV testing in HBV/HIV during routine practice the Netherlands. Methods We assessed data from ATHENA cohort of people who were ever HBV surface antigen-positive, aged ≥ 18 years attended one 24 treatment centres Netherlands 2000–22. Using longitudinal analysis, we estimated percentage (antibody or RNA test) over time. In cross-sectional determinants...
Background. The aim of this study was to investigate the association between immunodeficiency, viremia, and non–AIDS-defining malignancies (NADM). Methods. Patients starting combination antiretroviral therapy (cART) as 1 January 1996 were selected from AIDS Therapy Evaluation in Netherlands (ATHENA) cohort. In Cox models, risk factors for NADM investigated. These included age, sex, transmission route, smoking, alcohol abuse, prior diagnosis, duration exposure cART, estimated human...
Objectives: The health-related quality of life (HRQOL) people with HIV is lower than in the general population, but it unknown how compares that persons other chronic medical conditions. We compared HRQOL diabetes mellitus type 1, 2 and rheumatoid arthritis (RA). In addition, we investigated factors associated HIV. Design: Cross-sectional study. Methods: was measured Medical Outcomes Study Short Form 36-item Health Survey a nationwide sample care Netherlands on combination antiretroviral...
The Netherlands has provided unrestricted access to direct-acting antivirals (DAAs) since November 2015. We analyzed the nationwide hepatitis C virus (HCV) treatment uptake among patients coinfected with human immunodeficiency (HIV) and HCV.Data were obtained from ATHENA HIV observational cohort in which >98% of HIV-infected ever registered 1998 are included. Patients included if they had 1 positive HCV RNA result, did not have spontaneous clearance, known still be care. Treatment outcome...
Abstract Background Human immunodeficiency virus (HIV)-positive men who have sex with (MSM) are at high risk of hepatitis C (HCV) reinfection following clearance HCV, but factors specifically for never been comprehensively assessed. Methods Using data from a prospective observational cohort study among HIV-positive MSM an acute HCV infection (MOSAIC), the incidence spontaneous or successful treatment was A univariable Bayesian exponential survival model used to identify associated...
In Brief Objectives: the industrialized world, lymphogranuloma venereum proctitis (LGVP) has been reported only in men who have sex with men. Factors responsible for outbreak remain to be elucidated. GOAL: The goal of present work was elucidate risk factors associated LGVP. Study Design: study design comprised a cross-sectional including 32 LGVP and 93 without (22 gonorrheal proctitis, 30 non-LGV chlamydial 41 unknown etiology). were analyzed by (multinomial) logistic regression. Results:...
Background: Progression of liver-related disease is accelerated in individuals coinfected with HIV and hepatitis C virus (HCV). Because the life expectancy HIV-infected drug users (DUs) improved after widespread use highly active antiretroviral therapy (HAART), HCV-related death likely to become more important. To disentangle effects HCV HIV, we compared overall cause-specific mortality between HCV/HIV-infected DUs HCV-infected without or followed up 1985 2006. Methods: A total 1295...
Broad direct-acting antiviral (DAA) access may reduce hepatitis C virus (HCV) incidence through a "treatment as prevention" (TasP) effect. We assessed changes in primary HCV following DAA among people living with HIV (PLHIV).
Background. While the association between renal impairment and cardiovascular disease (CVD) is well established in general population, remains poorly understood human immunodeficiency virus (HIV)–positive individuals. Methods. Individuals with ≥2 estimated glomerular filtration rate (eGFR) measurements after 1 February 2004 were followed until CVD, death, last visit plus 6 months, or 2015. CVD was defined as occurrence of centrally validated myocardial infarction, stroke, invasive...
The benefits of combination anti-retroviral therapy (cART) in HIV-positive pregnant women (improved maternal health and prevention mother to child transmission [pMTCT]) currently outweigh the adverse effects due cART. As variety cART increases, however, question arises as which type is safest for childbearing age. We studied effect timing exposure different classes on birth outcomes a large HIV cohort Netherlands.We included singleton HEU infants registered ATHENA from 1997 2015....
Objective: To study temporal changes in HIV incidence, transmission routes, and both injecting sexual risk behaviour the open Amsterdam Cohort Study (ACS) among drug users. Initiated 1985, ACS enables us to trends since HAART became widespread 1996. Methods: Person-time techniques were used trend incidence HIV-negative routes determined using detailed standardised questionnaires. Trends behaviours evaluated with a logistic regression model adjusted for correlations between visits of same...
We surveyed trends in incidence (1995-2012) and risk factors for anal cancer the Dutch HIV-positive population. After an initial increase with a peak 2005-2006 of 114 [95% confidence interval (CI): 74 to 169] all HIV+ patients 168 (95% CI: 103 259) men who have sex (MSM), decline 72 43 113) 100 56 164), respectively, was seen 2011-2012. Low nadir CD4, alcohol use, smoking were significantly associated MSM. In conclusion, remains serious problem predominantly However, it seems that rates are...
Multiple studies have described a higher incidence of venous thromboembolism (VTE) in people living with an HIV infection (PWH). However, data on the risk recurrent VTE this population are lacking, although question is more important for clinical practice. This study aims to estimate PWH compared controls and identify factors recurrence within population.PWH first were derived from AIDS Therapy Evaluation Netherlands (ATHENA) cohort (2003-2015), nationwide ongoing following up care...
Background & AimsHepatitis B virus (HBV) coinfection is common among people living with HIV (PLWH) and the most important cause of hepatocellular carcinoma (HCC). Whereas risk prediction tools for HCC exist patients HBV monoinfection, they have not been evaluated in PLWH. We performed an external validation PAGE-B HIV/HBV coinfection.MethodsWe included PLWH a positive HBsAg without before starting tenofovir from four European cohorts, estimated predictive performance on occurrence over 15...
Abstract People with HIV (PWH) are at greater risk of experiencing mental health problems, such as depression and post-traumatic stress disorder (PTSD). The purpose our study was to determine the prevalence posttraumatic PTSD in PWH. PWH care Amsterdam University Medical center (Amsterdam UMC) access electronic patient portal were offered patient-reported outcome measures (PROMs) between May 2022 2023, including PC-PTSD-5 screen for part routine clinical care. Risk factors a clinically...
BackgroundPrevious studies have shown that health-related quality of life (HRQL) predicts survival in patients infected with human immunodeficiency virus (HIV). However, these predated the highly active antiretroviral therapy (HAART) era, included only a few receiving HAART, or had limited duration follow-up. This study investigates whether HRQL among HIV-infected HAART.
Background: Several studies reported an association between immunodeficiency and non–AIDS-defining diseases. We investigated whether nonstructured treatment interruptions episodes of viremia during suppressive combination antiretroviral therapy were independently associated with non-AIDS Methods: Six thousand four hundred forty patients viral suppression (<50 copies/mL) within 48 weeks starting selected from the Dutch ATHENA cohort. In proportional hazards models, associations interruptions,...
Cardiovascular disease (CVD) is expected to contribute a large noncommunicable burden among human immunodeficiency virus (HIV)-infected people. We quantify the impact of prevention interventions on annual CVD and costs HIV-infected people in Netherlands.
Men who have sex with men (MSM) acute human immunodeficiency virus (HIV) infection (AHI) are a key source of new infections. To curb transmission, we implemented strategy for rapid AHI diagnosis and immediate initiation combination antiretroviral therapy (cART) in Amsterdam MSM. We assessed its effectiveness diagnosing decreasing the time to viral suppression.We included 63 278 HIV testing visits 2008-2017, during which 1013 MSM were diagnosed. Standard care (SOC) confirmation < 1 week cART...