A5074453500- Hepatitis C virus research
- Hepatitis B Virus Studies
- Liver Disease Diagnosis and Treatment
- HIV/AIDS drug development and treatment
- Immune Cell Function and Interaction
- HIV Research and Treatment
- T-cell and B-cell Immunology
- Systemic Lupus Erythematosus Research
- HIV/AIDS Research and Interventions
- HIV-related health complications and treatments
- Antimicrobial Resistance in Staphylococcus
- Pneumocystis jirovecii pneumonia detection and treatment
- COVID-19 Impact on Reproduction
- Infective Endocarditis Diagnosis and Management
- Kawasaki Disease and Coronary Complications
- Cytomegalovirus and herpesvirus research
- HIV/AIDS Impact and Responses
- Liver Disease and Transplantation
- Antibiotic Use and Resistance
- Clostridium difficile and Clostridium perfringens research
- Viral Infections and Vectors
- Radiomics and Machine Learning in Medical Imaging
- T-cell and Retrovirus Studies
- COVID-19 Clinical Research Studies
- Patient Satisfaction in Healthcare
Rijnstate Hospital
2017-2025
Amsterdam University Medical Centers
2022-2024
University of Amsterdam
2022-2023
Stichting HIV Monitoring
2023
National Institute for Public Health and the Environment
2018
Veiligheids- en Gezondheidsregio Gelderland-Midden
2018
Netherlands Food and Consumer Product Safety Authority
2018
Erasmus MC
2008-2017
Erasmus University Rotterdam
2012-2017
Direct-acting antivirals (DAAa) cure hepatitis C virus (HCV) infections in 95% of infected patients. Modeling studies predict that universal HCV treatment will lead to a decrease the incidence new but real-life data are lacking. The among Dutch human immunodeficiency (HIV)-positive men who have sex with (MSM) has been high for >10 years. In 2015 DAAs became available all patients and resulted rapid uptake HIV-positive MSM. We assessed whether this was followed by infections.Two prospective...
Background Since 2009, European guidelines recommend individuals with hepatitis B virus (HBV) and HIV be tested for D (HDV). Aim To analyse HDV testing in HBV/HIV during routine practice the Netherlands. Methods We assessed data from ATHENA cohort of people who were ever HBV surface antigen-positive, aged ≥ 18 years attended one 24 treatment centres Netherlands 2000–22. Using longitudinal analysis, we estimated percentage (antibody or RNA test) over time. In cross-sectional determinants...
Objective Mucosal-associated invariant T (MAIT) cells comprise a subpopulation of that can be activated by bacterial products and cytokines to produce IFN-γ. Since little is known on MAIT during HCV infection, we compared their phenotype function in comparison HIV HCV/HIV co-infected patients, determined the effect IFN-α-based direct-acting antiviral therapy patients. Methods Blood samples from patients with chronic (CHCV), virologically suppressed HIV, acute co-infection (AHCV/HIV) healthy...
Sub-Saharan African (SSA) ethnicity has been associated with a higher risk of hepatocellular carcinoma (HCC) among individuals chronic hepatitis B in cross-sectional studies. However, the incidence HCC and performance scores this population are unknown.
Following infection with the hepatitis C virus (HCV), in most cases immunity fails to eradicate virus, resulting slowly progressing immunopathology HCV-infected liver. We are first examine intrahepatic T cells and CD4(+) CD25(+) FoxP3(+) regulatory (Treg) patients chronically infected HCV (chronic patients) during after antiviral therapy by collecting multiple aspiration biopsy samples from liver at different time points. found that Treg frequencies were increased upon alpha interferon...
Abstract Background & Aims Mucosal‐associated invariant T ( MAIT ) cells are important innate with antimicrobial and immunoregulatory activity, recently found to be depleted in blood of patients HIV HCV mono‐infections. In this study, we assessed the impact , / co‐infection on circulating intrahepatic ‐cells correlations liver fibrosis. Methods cross‐sectional nine healthy subjects, 20 22 co‐infected were included. Blood fine needle aspirate biopsies studied using flowcytometry for CD 3...
Abstract Orthohantaviruses are a group of rodentborne viruses with worldwide distribution. The orthohantavirus Seoul virus (SEOV) can cause hemorrhagic fever renal syndrome in humans and is distributed worldwide, like its reservoir host, the rat. Cases SEOV wild pet rats have been described several countries, human cases reported United Kingdom, France, Canada, States. In Netherlands, has previously found brown rats. We describe an autochthonous case infection Netherlands. This patient had...
Little is known about the immune status in liver and blood of patients with chronic hepatitis C virus (HCV) infection long after therapy-induced viral clearance. In this study, we demonstrate that, 4 years clearance, regulation HCV-specific immunity by regulatory T cells (Tregs) immunosuppressive cytokines interleukin 10 transforming growth factor β still ongoing. Importantly, analysis specimens collected HCV clearance shows that intrahepatic Tregs are present all patients, suggesting remain...
ABSTRACT Systems biology has proven to be a powerful tool identify reliable predictors of treatment response in chronic hepatitis C virus (HCV) infection. In the present study, we studied patients with HCV infection who responded interferon (IFN)-based therapy, as evidenced by an absence RNA at end treatment, and focused on two issues that have not received much attention. First, evaluated whether specific genes or gene expression patterns blood were able distinguish responder viral relapse...
Sustained immune activation during chronic HIV infection is considered to augment co-morbidity and mortality. Effective combination antiretroviral therapy (cART) has shown dampen especially the first year cART, but effects of long-term cART in patients without major comorbidities remains under-investigated. We performed a comprehensive analysis including cellular, intracellular plasma biomarkers study effect on parameters 5 groups 10 patients. All were co-morbidities grouped based duration...
ABSTRACT Background Severe flares (ALT ≥ 10×ULN) are a well‐recognised adverse outcome after nucleos(t)ide analogue (NA) cessation and may lead to liver failure. Thus, identification of patients at risk for these is major importance. Methods Data were used from two prospective studies on NA conducted in the Netherlands Canada. Patients eligible based EASL criteria. HBcrAg anti‐HBc levels measured end treatment (EOT) week 6 (FUW6). Logistic regression was study association with severe flares....
The vitamin D endocrine system has been shown to influence the immune response and polymorphisms in receptor (VDR) gene have associated with susceptibility infectious diseases. We determined if Cdx2, FokI BsmI-ApaI-TaqI VDR were nasal carriage of Staphylococcal aureus. defined S. aureus status (persistent, intermittent or non-carriage) for a group more that 2000 elderly volunteers. prevalence persistent was 18%, which was, however, not any variant genotypes. Our study into genetic...
A 38-year-old male patient presented to the emergency department with fever and dyspnea. Hospitalization was warranted soon coronavirus disease 2019 (COVID-19) diagnosed based on a positive SARS-CoV-2-PCR. Over following weeks his condition gradually worsened, leading admission at intensive care unit. Because of unexplained weight loss before admission, HIV screening performed. confirmed additional tests showed an undetectable CD4+ T cell count, alongside number co-infections. Convalescent...
Specific inhibitory mechanisms suppress the T-cell response against hepatitis C virus (HCV) in chronically infected patients. However, relative importance of suppression by IL-10, TGF-β and regulatory T-cells impact pegylated interferon-alpha ribavirin (PegIFN-α/ribavirin) therapy on these are still unclear. We revealed that coregulation HCV-specific responses blood 43 chronic HCV patients showed a highly heterogeneous pattern before, during after PegIFN-α/ribavirin. Prior to treatment,...