A5085813010- Genomics and Chromatin Dynamics
- Epigenetics and DNA Methylation
- RNA Research and Splicing
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Cancer Genomics and Diagnostics
- Chromosomal and Genetic Variations
- Immune Cell Function and Interaction
- Glioma Diagnosis and Treatment
- MicroRNA in disease regulation
- CRISPR and Genetic Engineering
- Brain Metastases and Treatment
- Congenital gastrointestinal and neural anomalies
- Hemoglobinopathies and Related Disorders
- Radiomics and Machine Learning in Medical Imaging
- Intestinal Malrotation and Obstruction Disorders
- T-cell and B-cell Immunology
- Genetics and Neurodevelopmental Disorders
- Single-cell and spatial transcriptomics
- Prenatal Screening and Diagnostics
- Immunotherapy and Immune Responses
- Pluripotent Stem Cells Research
- Immune cells in cancer
- Zebrafish Biomedical Research Applications
- Cancer-related gene regulation
Erasmus University Rotterdam
2015-2025
Erasmus MC
2016-2025
Institute of Cell Biology
2025
Rotterdam University of Applied Sciences
2025
Weatherford College
2024
Harokopio University of Athens
2022
Medical University of Lublin
2022
Laboratory of Molecular Genetics
2022
Instytut Biologii Doświadczalnej im. Marcelego Nenckiego
2022
Polish Academy of Sciences
2022
Protecting plants from the inside out Some soils show a remarkable ability to suppress disease caused by plant pathogens, an that is attributed plant-associated microbiota. Carrión et al. investigated role of endophytes, intimate microbial community found within roots, in fungal suppression (see Perspective Tringe). The wilt fungus Rhizoctonia solani infects sugar beets, whereupon transcriptional analysis shows several bacterial endophyte species activate biosynthetic gene clusters cause...
Significance For the 2m DNA to fit into tiny cell nucleus, it is wrapped around nucleosomes and folded loops clustering together in domains. Genome function depends on this 3D-organization, especially on-going dynamic processes like transcription. Techniques studying network of contacts genome-wide have recently revealed 3D architecture, but protein factors behind are not understood. We study two proteins that known help form loops: cohesin CTCC-binding factor (CTCF). Respective depletion...
Current clinical therapy of non-small cell lung cancer depends on histo-pathological classification. This approach poorly predicts outcome for individual patients. Gene expression profiling holds promise to improve stratification, thus paving the way individualized therapy.A genome-wide gene analysis was performed a cohort 91 We used tumor- and 65 adjacent normal tissue samples. defined sets predictor genes (probe sets) with profiles. The power evaluated using an independent 96 cancer- 6...
Epithelial ovarian cancer is a highly heterogeneous disease and remains the most lethal gynaecological malignancy in Western world. Therapeutic approaches need to account for inter-patient intra-tumoural heterogeneity detailed characterization of vitro models representing different histological molecular subtypes critical enable reliable preclinical testing. There are approximately 100 publicly available cell lines but their cellular characteristics largely undescribed. We have characterized...
The emergence of viral respiratory pathogens with pandemic potential, such as severe acute syndrome coronavirus (SARS-CoV) and influenza A H5N1, urges the need for deciphering their pathogenesis to develop new intervention strategies. SARS-CoV infection causes lung injury (ALI) that may into life-threatening distress (ARDS) advanced age correlating positively adverse disease outcome. molecular pathways, however, cause virus-induced ALI/ARDS in aged individuals are ill-defined. Here, we show...
Three-dimensional topology of DNA in the cell nucleus provides a level transcription regulation beyond sequence linear DNA. To study relationship between transcriptional activity and spatial environment gene, we used allele-specific chromosome conformation capture-on-chip (4C) technology to produce high-resolution maps active inactive X chromosomes female cells. We found that loci on form multiple long-range interactions, with segregation chromatin. On X, silenced lack preferred suggesting...
Pseudo-TORCH syndrome (PTS) is characterized by microcephaly, enlarged ventricles, cerebral calcification, and, occasionally, systemic features at birth resembling the sequelae of congenital infection but in absence an infectious agent. Genetic defects resulting activation type 1 interferon (IFN) responses have been documented to cause Aicardi-Goutières syndrome, which a PTS. Ubiquitin-specific peptidase 18 (USP18) key negative regulator I IFN signaling. In this study, we identified...
Despite the clinical success of immune checkpoint blockade (ICB), in certain cancer types, most patients with do not respond well. Furthermore, for whom ICB is initially successful, this often short-lived because development resistance to ICB. The mechanisms underlying primary or secondary are incompletely understood. Here, we identified preferential activation and enhanced suppressive capacity regulatory T cells (Treg cells) αPD-L1 therapy-resistant solid tumor-bearing mice. Treg cell...
Summary Dietary restriction (DR) extends lifespan and increases resistance to multiple forms of stress, including ischemia reperfusion injury the brain heart in rodents. While maximal effects on require long‐term restriction, kinetics onset benefits against acute stress is not known. Here, we show that 2–4 weeks 30% DR improved survival kidney function following renal mice. Brief periods water‐only fasting were similarly effective at protecting ischemic damage. Significant protection...
One of the complexes formed by hematopoietic transcription factor Gata1 is a complex with Ldb1 (LIM domain-binding protein 1) and Tal1 proteins. It known to be important for development differentiation erythroid cell lineage thought implicated in long-range interactions. Here, dynamics composition complex—in particular, binding negative regulators Eto2 Mtgr1—are studied, context their genome-wide targets. This shows that acts almost exclusively as an activator, very specific combination...
There is emerging interest in the application of mesenchymal stem cells (MSC) for prevention and treatment autoimmune diseases, graft-versus-host disease allograft rejection. It is, however, unknown how inflammatory conditions affect phenotype function MSC. Adipose tissue-derived (ASC) were cultured with alloactivated peripheral blood mononuclear (PBMC) (mixed lymphocyte reaction: MLR), proinflammatory cytokines [interferon (IFN)-γ, tumour necrosis factor (TNF)-α interleukin (IL)-6] or under...
Mutant dwarf and calorie-restricted mice benefit from healthy aging unusually long lifespan. In contrast, mouse models for DNA repair-deficient progeroid syndromes age die prematurely. To identify mechanisms that regulate mammalian longevity, we quantified the parallels between genome-wide liver expression profiles of with those two extremes Contrary to expectation, find significant, associations long-lived mice. Subsequent analysis significantly over-represented biological processes...