A5039030132- Neonatal and fetal brain pathology
- Neonatal Respiratory Health Research
- Infant Development and Preterm Care
- Fetal and Pediatric Neurological Disorders
- Neuroscience of respiration and sleep
- Advanced Neuroimaging Techniques and Applications
- Congenital Heart Disease Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Atomic and Subatomic Physics Research
- Non-Invasive Vital Sign Monitoring
- Blood Coagulation and Thrombosis Mechanisms
- Advanced MRI Techniques and Applications
- Pregnancy and preeclampsia studies
- Cerebral Venous Sinus Thrombosis
- Acute Ischemic Stroke Management
- Anesthesia and Neurotoxicity Research
- Cardiac Arrest and Resuscitation
- Prenatal Screening and Diagnostics
- Cerebrospinal fluid and hydrocephalus
- Language Development and Disorders
- Birth, Development, and Health
- Cerebral Palsy and Movement Disorders
- Infant Health and Development
- Metabolism and Genetic Disorders
- Optical Imaging and Spectroscopy Techniques
Wilhelmina Children's Hospital
2016-2025
University Medical Center Utrecht
2016-2025
Utrecht University
2018-2025
University Medical Center
2023
University Hospital and Clinics
2023
Erasmus MC
2009-2022
Google (United States)
2022
Erasmus MC - Sophia Children’s Hospital
2011-2020
Pediatrics and Genetics
2018
Heidelberg University
2018
Pseudo-TORCH syndrome (PTS) is characterized by microcephaly, enlarged ventricles, cerebral calcification, and, occasionally, systemic features at birth resembling the sequelae of congenital infection but in absence an infectious agent. Genetic defects resulting activation type 1 interferon (IFN) responses have been documented to cause Aicardi-Goutières syndrome, which a PTS. Ubiquitin-specific peptidase 18 (USP18) key negative regulator I IFN signaling. In this study, we identified...
Hypoxic-ischemic encephalopathy (HIE) in preterm infants is a severe disease for which no curative treatment available. Cerebral inflammation and invasion of activated peripheral immune cells have been shown to play pivotal role the etiology white matter injury, clinical hallmark HIE infants. The objective this study was assess neuroprotective anti-inflammatory effects intravenously delivered mesenchymal stem (MSC) an ovine model HIE. In translational animal model, global hypoxia-ischemia...
<h3>Objective</h3> To investigate detection ability and feasibility of serial cranial ultrasonography (CUS) early MRI in preterm brain injury. <h3>Design</h3> Prospective cohort study. <h3>Setting</h3> Level III neonatal intensive care unit. <h3>Patients</h3> 307 infants, born below 29 weeks gestation. <h3>Methods</h3> Serial CUS were performed according to standard clinical protocol. In case instability, was postponed or cancelled. Brain images assessed by independent experts compared...
To determine the prevalence of and to classify ultrasound-proven brain injury during neonatal extracorporeal membrane oxygenation in The Netherlands.Retrospective nationwide study (Rotterdam Nijmegen), spanning two decades.Level III university hospitals.All neonates who underwent from 1989 2010.None.Cranial ultrasound images were reviewed independently by investigators without knowledge primary diagnosis, outcome, type oxygenation, or statistics. scans for lesion timing, with use a refined...
To report the incidence of cerebral sinovenous thrombosis (CSVT) in a prospective cohort preterm infants with gestational age less than 29 weeks.The local medical ethics review board approved this study, and written parental consent was obtained. Preterm weeks who were admitted to neonatal intensive care unit prospectively studied cranial ultrasonography (US). The scanning protocol included visualization color Doppler imaging superior sagittal sinus transverse sinuses through anterior...
Sleep is a natural phenomenon controlled by the central nervous system. The sleep-wake pattern, which functions as an essential indicator of neurophysiological organization in neonatal period, has profound meaning prediction cognitive diseases and brain maturity. In recent years, unobtrusive sleep monitoring automatic staging have been intensively studied for adults, but much less neonates. This work aims to investigate novel video-based method classification analyzing behavioral changes...
Abstract Background Despite therapeutic hypothermia (TH) and neonatal intensive care, 45–50% of children affected by moderate-to-severe hypoxic-ischemic encephalopathy (HIE) die or suffer from long-term neurodevelopmental impairment. Additional neuroprotective therapies are sought, besides TH, to further improve the outcome infants. Allopurinol — a xanthine oxidase inhibitor reduced production oxygen radicals subsequent brain damage in pre-clinical preliminary human studies cerebral ischemia...