Tuuli Metsvaht

ORCID: 0000-0003-3206-3092
Publications
Citations
Views
---
Saved
---
About
Contact & Profiles
Research Areas
  • Neonatal and Maternal Infections
  • Antibiotics Pharmacokinetics and Efficacy
  • Neonatal Respiratory Health Research
  • Pharmaceutical studies and practices
  • Sepsis Diagnosis and Treatment
  • Neonatal Health and Biochemistry
  • Neonatal and fetal brain pathology
  • Pneumonia and Respiratory Infections
  • Antimicrobial Resistance in Staphylococcus
  • Bacterial Identification and Susceptibility Testing
  • Streptococcal Infections and Treatments
  • Anesthesia and Sedative Agents
  • Infant Nutrition and Health
  • Analytical Methods in Pharmaceuticals
  • Renal function and acid-base balance
  • Nosocomial Infections in ICU
  • Pregnancy and preeclampsia studies
  • Child Abuse and Related Trauma
  • Clostridium difficile and Clostridium perfringens research
  • Anesthesia and Neurotoxicity Research
  • Antibiotic Resistance in Bacteria
  • Blood Coagulation and Thrombosis Mechanisms
  • Traumatic Brain Injury and Neurovascular Disturbances
  • Cardiovascular Conditions and Treatments
  • Neurogenetic and Muscular Disorders Research

University of Tartu
2014-2024

Tartu University Hospital
2015-2024

PENTA Foundation
2024

Intensive Care Society
2018

European Society of Anaesthesiology
2017

Czech Academy of Sciences, Institute of Microbiology
2015

Boston Children's Museum
2010

Boston Children's Hospital
2010

Nemours Children’s Clinic
2007

There are not very many epidemiological studies on perinatal stroke, and authors suggest that this may be an underdiagnosed condition. The aim of the study was to estimate incidence arterial ischemic hemorrhagic stroke in Estonia, first clinical signs identify possible differences predisposing factors outcome between acutely retrospectively diagnosed cases stroke.A retro- prospective (within month) conducted a children population born eastern southern regions Estonia during years 1994 2003....

10.1161/strokeaha.107.483743 article EN Stroke 2007-06-22

Antibiotic dosing in neonates varies between countries and centres, suggesting suboptimal exposures for some neonates. We aimed to describe variations factors influencing the variability of frequently used antibiotics European NICUs help define strategies improvement. A sub-analysis Study Neonatal Exposure Excipients point prevalence study was undertaken. Demographic data receiving any antibiotic on day within one three two-week periods from January June 2012, dose, interval route...

10.1186/s12887-015-0359-y article EN cc-by BMC Pediatrics 2015-04-15

Sepsis and bacterial meningitis are major causes of mortality morbidity in neonates infants. Meropenem, a broad-spectrum antibiotic, is not licensed for use infants below 3 months age sufficient information on its plasma CSF disposition dosing lacking. To determine pharmacokinetics meropenem young the link between clinical outcomes babies with late-onset sepsis (LOS). Data were collected two recently conducted studies, i.e. NeoMero-1 (neonatal LOS) NeoMero-2 meningitis). Optimally timed...

10.1093/jac/dky128 article EN cc-by Journal of Antimicrobial Chemotherapy 2018-03-16

Perinatal asphyxia and resulting hypoxic-ischemic encephalopathy is a major cause of death long-term disability in term born neonates. Up to 20,000 infants each year are affected by HIE Europe even more regions with lower level perinatal care. The only established therapy improve outcome these therapeutic hypothermia. Allopurinol xanthine oxidase inhibitor that reduces the production oxygen radicals as superoxide, which contributes secondary energy failure apoptosis neurons glial cells after...

10.1186/s12887-019-1566-8 article EN cc-by BMC Pediatrics 2019-06-27

Objectives We aimed to describe administration of eight potentially harmful excipients interest (EOI)—parabens, polysorbate 80, propylene glycol, benzoates, saccharin sodium, sorbitol, ethanol and benzalkonium chloride—to hospitalised neonates in Europe identify risk factors for exposure. Methods All medicines administered during 1 day with individual prescription demographic data were registered a web-based point prevalence study. Excipients identified from the Summaries Product...

10.1136/archdischild-2014-307793 article EN Archives of Disease in Childhood 2015-04-08

The early use of broad-spectrum antibiotics remains the cornerstone for treatment neonatal late onset sepsis (LOS). However, which should be used is still debatable, as relevant studies were conducted more than 20 years ago, recruited in single centres or countries, evaluated not clinical anymore and had variable inclusion/exclusion criteria outcome measures. Moreover, antibiotic-resistant bacteria have become a major problem many countries worldwide. We hypothesized that efficacy meropenem...

10.1371/journal.pone.0229380 article EN cc-by PLoS ONE 2020-03-04
Corinna Engel Mario Rüdiger Manon J.N.L. Benders Frank van Bel Karel Allegaert and 95 more Gunnar Naulaers Dirk Bassler Katrin Klebermaß-Schrehof Máximo Vento Ana Vilan Mari Falck Isabella Mauro Marjo Metsäranta Sampsa Vanhatalo Jan Mazela Tuuli Metsvaht Roselinda van der Vlught Axel R. Franz Christian F. Poets Hercília Guimarães Tom Stiri Luigi Cattarossi Cees K. W. van Veldhuizen Christian A. Maiwald Iris Bergmann Monika Weiß Andreas Eichhorn Michael Raubuch Birgit Schuler Bas Laméris Thirza van Ramshorst Tirol Kliniken Johannes Brandner Marie Tackoen R. Reibel Mari‐Liis Ilmoja Pille Saik Ruth Käär Pille Andresson Klinikum der J. W. Goethe M. Schloesser Carl Gustav Carus Stefan Winkler Thomas Hoehn Norbert Teig Michael Schroth Christoph Fusch Ulrich Thomé Harald Ehrhardt Ancona Virgilio Carnielli Marcello Napolitano Francesca Faldini Bambini “V.Buzzi” Milano Gianluca Lista Mario Barbarini Laura Pagani Emmanuele Mastretta Giovanni Vento Monica Fumagalli Mirjam M. van Weissenbruch H. L. M. van Straaten Kim V. Annink Jeroen Dudink Jan Derks Inge P. de Boer Clemens B. Meijssen Timo R. de Haan Linda G. van Rooij Jacqueline L. van Hillegersberg Minouche van Dongen Koen P. Dijkman Marlies A. van Houten Sophie R. D. van der Schoor Moritz Schneider Eirik Nestaas Britt Nakstad Lukas Karpinski Ewa Gulczyńska Cláudia Ferraz Almerinda Pereira Rosalina Barroso Mendes da Graça Teresa Tomé Filomena Pinto Juan Martínez Rodilla Maria Luz.Couce Pico José Suazo Eva Valverde José Ramón Fernández Lorenzo Héctor Boix Francisco Jiménez Parrilla Dorotea Blanco Begoña Loureiro María Teresa Moral‐Pumarega Julia Maletzki Claudia Knöepfli Cornelia Hagmann Michael Kleber Martin Stocker Thomas Riedel

Abstract Background Despite therapeutic hypothermia (TH) and neonatal intensive care, 45–50% of children affected by moderate-to-severe hypoxic-ischemic encephalopathy (HIE) die or suffer from long-term neurodevelopmental impairment. Additional neuroprotective therapies are sought, besides TH, to further improve the outcome infants. Allopurinol — a xanthine oxidase inhibitor reduced production oxygen radicals subsequent brain damage in pre-clinical preliminary human studies cerebral ischemia...

10.1186/s13063-023-07828-6 article EN cc-by Trials 2024-01-24

We aimed to compare the clinical efficacy of ampicillin (AMP) vs. penicillin (PEN) both combined with gentamicin in empirical treatment neonates at risk early onset neonatal sepsis (EOS).We performed an open label cluster randomized equivalence study Estonian intensive care units, including suspected EOS, aged less than 72 h. Primary end-point was failure rate, expressed by need for change antibiotic regimen within h and/or 7-day all cause mortality. Bowel colonization followed biweekly...

10.1111/j.1651-2227.2010.01687.x article EN Acta Paediatrica 2010-01-20

Coagulase-negative staphylococci (CoNS) are the first colonizers of gastrointestinal tract (GIT) and commonest cause late-onset sepsis (LOS) in preterm neonates. Intravascular catheters considered a major source CoNS bacteremia. However, several cases LOS remain without an identified source. To elucidate whether GIT could be potential invasive strains, we aimed to assess molecular similarity between from blood neonates with LOS.Altogether 22 53 isolates collected caused by (Staphylococcus...

10.1097/inf.0b013e3182791abd article EN The Pediatric Infectious Disease Journal 2012-10-18

Prolonged infusion of meropenem has been suggested in studies with population pharmacokinetic modeling but not tested neonates. We compared the steady-state pharmacokinetics (PK) given as a short (30-min) or prolonged (4-h) to very-low-birth-weight (gestational age, <32 weeks; birth weight, <1,200 g) neonates define appropriate dosing regimen for phase 3 efficacy study. Short (n = 9) 10) infusions were at dose 20 mg/kg every 12 h. Immediately before and 0.5, 1.5, 4, 8, h after 4th 7th doses...

10.1128/aac.00655-12 article EN Antimicrobial Agents and Chemotherapy 2012-06-27

Objective: An increasing number of studies that are using high-throughput molecular methods rapidly extending our knowledge gut microbial colonization in preterm infants whose immaturity and requirement for extensive treatment may result altered process. We aimed to describe the profile microbiota 50 extremely low birth weight (<1200 g) critically ill at three different time points during first two months life by 16S rRNA gene specific sequencing. Patients Methods: Stool samples were...

10.4161/gmic.28849 article EN Gut Microbes 2014-04-10

Aim : To evaluate the role of early (up to 12h) changes in cerebral blood‐flow (CBF) velocity predicting severity hypoxic‐ischaemic encephalopathy (HIE) and long‐term outcome asphyxiated term infants. Methods CBF velocities were investigated by colour Doppler ultrasonography 81 healthy 60 infants at least three times during first 5 d life. The psychomotor development was followed up 18 mo. Results No differences found age 2–6 h between with severe mild‐moderate HIE, mean [mean (95% CI...

10.1080/08035250410024745 article EN Acta Paediatrica 2004-04-01

Inflicted traumatic brain injury (ITBI) or shaken baby syndrome (SBS) is recognized as a major cause of disability and death in the paediatric population.To find out incidence ITBI Estonia.26 cases were recognized: four children died, 22 survived.Of 26 children, 20 (77%) boys six (23%) girls. Median age at admission to hospital was 3.9 mo, younger than girls.The overall 28.7 per 100,000 infants. In prospective group 40.5 100,000, retrospective 13.5 100,000. not rare but always form child...

10.1080/08035250500464923 article EN Acta Paediatrica 2006-02-17

Despite differences in types of infection and causative organisms, pharmacokinetic-pharmacodynamic (PKPD) targets vancomycin therapy derived from adult studies are suggested for neonates. We aimed to identify doses needed the attainment AUC/MIC > 400 300 neonates with sepsis correlate these recommended treatment outcome. Neonates who had Vancomycin therapeutic drug monitoring (TDM) performed between January 1, 2010 December 31, 2012 were studied. Clinical characteristics, episodes...

10.1186/s12887-016-0753-0 article EN cc-by BMC Pediatrics 2016-12-01

We recruited 48 neonates (50 vancomycin treatment episodes) in a prospective study to validate model-informed precision dosing (MIPD) software. The initial dose was based on population pharmacokinetic model and adjusted every 36-48 h. Compared with historical control group of 53 (65 episodes), the achievement target trough concentration 10-15 mg/L improved from 37% 62% MIPD (

10.1128/aac.01591-23 article EN cc-by Antimicrobial Agents and Chemotherapy 2024-04-05
Coming Soon ...