A5070963513- Pharmaceutical studies and practices
- Antibiotics Pharmacokinetics and Efficacy
- Medication Adherence and Compliance
- Advancements in Transdermal Drug Delivery
- Analytical Methods in Pharmaceuticals
- Asthma and respiratory diseases
- Antibiotic Use and Resistance
- Pharmacogenetics and Drug Metabolism
- Drug Solubulity and Delivery Systems
- Pharmaceutical Practices and Patient Outcomes
- Advanced Drug Delivery Systems
- Child and Adolescent Health
- Pharmacological Effects and Toxicity Studies
- Health Systems, Economic Evaluations, Quality of Life
- Inhalation and Respiratory Drug Delivery
- Pneumonia and Respiratory Infections
- Clostridium difficile and Clostridium perfringens research
- Cystic Fibrosis Research Advances
- Heart Failure Treatment and Management
- Acute Lymphoblastic Leukemia research
- Pharmaceutical Economics and Policy
- Respiratory and Cough-Related Research
- Drug Transport and Resistance Mechanisms
- Blood Pressure and Hypertension Studies
- Nosocomial Infections in ICU
Queen's University Belfast
2014-2024
Antrim Area Hospital
2018
University of Ulster
2018
Northern Health and Social Care Trust
2018
Royal Belfast Hospital for Sick Children
2008-2013
Belfast Health and Social Care Trust
2008-2013
Czech Academy of Sciences, Biology Centre
2007-2011
Weatherford College
2007-2010
Mater Hospital
2009
Roche (United States)
2009
To evaluate the impact of a high-risk antibiotic stewardship programme on reducing use and hospital Clostridium difficile infection (CDI) incidence rates. A secondary objective was to present possible utility time-series analysis as an risk classification tool. This interventional, retrospective, ecological investigation in medium-sized over 6.5 years (January 2004 June 2010). The intervention restriction antibiotics (second-generation cephalosporins, third-generation fluoroquinolones...
We describe, for the first time use of hydrogel-forming microneedle (MN) arrays minimally-invasive extraction and quantification drug substances glucose from skin in vitro vivo. MN prepared aqueous blends hydrolysed poly(methyl-vinylether-co-maleic anhydride) (11.1% w/w) poly(ethyleneglycol) 10,000 daltons (5.6% crosslinked by esterification swelled upon insertion uptake fluid. Post-removal, theophylline caffeine were extracted determined using HPLC, with quantified a proprietary kit. In...
Methicillin-resistant Staphylococcus aureus (MRSA) is a major nosocomial pathogen worldwide. A wide range of factors have been suggested to influence the spread MRSA. The objective this study was evaluate effect antimicrobial drug use and infection control practices on MRSA incidence in 426-bed general teaching hospital Northern Ireland.The present research involved retrospective collection monthly data usage antibiotics within over 5 year period (January 2000-December 2004). multivariate...
We describe, for the first time, hydrogel-forming microneedle (s) (MN) arrays minimally-invasive extraction and quantification of lithium in vitro vivo. MN arrays, prepared from aqueous blends hydrolysed poly(methyl-vinylether-co-maleic anhydride) crosslinked by poly(ethyleneglycol), imbibed interstitial fluid (ISF) upon skin insertion. Such were always removed intact. In vitro, mean detected concentrations showed no significant difference following 30min application to excised neonatal...
We evaluated a structured pharmaceutical care program for elderly patients (> 65 yrs) with congestive heart failure (CHF) based on objective measures of disease control, quality life, and use health facilities in randomized, controlled, longitudinal, prospective clinical trial. The 42 group A received education from pharmacist the its treatment, lifestyle changes that could help control symptoms. Patients also were encouraged to monitor their symptoms comply prescribed drug therapy. If...
Study Objective. To implement and assess a community‐based pharmaceutical care program for patients with asthma. Design. Prospective, randomized, controlled trial. Setting. Community pharmacies (11 control, 11 intervention) in Malta. Patients. Community‐dwelling Interventions. A comprehensive asthma education monitoring was implemented. Intervention received verbal counseling, an educational video, information leaflet, subsequent reinforcement; control routine dispensing services....
Aims. To evaluate whether a structured community pharmacy‐based smoking cessation programme (the PAS model) would give rise to higher rate compared with ad hoc advice from pharmacists. Design. A randomized controlled trial comparing intervention usual care. Setting. One hundred pharmacists working in pharmacies N. Ireland and 24 London took part the study were each asked enroll 12 smokers; 44% of who trained managed recruit one or more smokers during recruitment period approximately 1 year....
The aim was to investigate the impact of a disease and medicine management programme, focusing on self-management in patients with chronic obstructive pulmonary (COPD).
To examine the allelic variation of three enzymes involved in 6-mercaptopurine/azathioprine (6-MP/AZA) metabolism and evaluate influence these polymorphisms on toxicity, haematological parameters metabolite levels patients with acute lymphoblastic leukaemia (ALL) or inflammatory bowel disease (IBD).Clinical data blood samples were collected from 19 ALL paediatric 35 IBD who receiving 6-MP/AZA therapy. All screened for seven genetic mercaptopurine [xanthine oxidase, inosine triphosphatase...
• The emergence and spread of bacteria producing extended-spectrum beta-lactamases (ESBLs) has important therapeutic epidemiologic implications. A key target for the establishment hospital antibiotic stewardship is reducing occurrence additional resistance. Further research needed to accumulate supporting evidence that use will result in a parallel reduction resistance.• Fluoroquinolone restriction reversed ciprofloxacin resistance primary secondary healthcare settings. reduced...
Aims Preterm infants are deprived of the normal intra‐uterine exposure to maternal melatonin and may benefit from replacement therapy. We conducted a pharmacokinetic study guide potential therapeutic trials. Methods Melatonin was administered 18 preterm in doses ranging 0.04–0.6 μg kg −1 over 0.5–6 h. Pharmacokinetic profiles were analyzed individually by population methods. Results Baseline largely undetectable. Infants receiving at 0.1 h for 2 showed median half‐life 15.82 maximum plasma...
Antibiotic dosing in neonates varies between countries and centres, suggesting suboptimal exposures for some neonates. We aimed to describe variations factors influencing the variability of frequently used antibiotics European NICUs help define strategies improvement. A sub-analysis Study Neonatal Exposure Excipients point prevalence study was undertaken. Demographic data receiving any antibiotic on day within one three two-week periods from January June 2012, dose, interval route...
Adherence to treatment is often reported be low in children with cystic fibrosis. fibrosis an important research area and more needed better understand family barriers adherence order for clinicians provide appropriate intervention. The aim of this study was evaluate enzyme supplements, vitamins chest physiotherapy determine if any modifiable risk factors are associated adherence. A sample 100 (≤18 years) (44 male; median [range] 10.1 [0.2-18.6] their parents were recruited the from Northern...
Visual impairment (VI) is rising in prevalence and contributing to increasing morbidity, particularly among older people. Understanding patients' problems fundamental achieving optimal health outcomes but little known about how VI impacts on self-management of medication.To compare issues relating medication between people with without VI.Case-control study participants aged ≥65 years, prescribed at least two long-term oral medications daily, living within the community.The recruited 156...