A5007487857- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- Renal Transplantation Outcomes and Treatments
- Renal Diseases and Glomerulopathies
- Cytokine Signaling Pathways and Interactions
- COVID-19 epidemiological studies
- Systemic Lupus Erythematosus Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Reproductive System and Pregnancy
- Immunodeficiency and Autoimmune Disorders
- Neonatal and fetal brain pathology
- Neurogenesis and neuroplasticity mechanisms
- Neonatal Respiratory Health Research
- Multiple Sclerosis Research Studies
- Immune Response and Inflammation
- Complement system in diseases
- MicroRNA in disease regulation
- Blood groups and transfusion
- Vasculitis and related conditions
- SARS-CoV-2 and COVID-19 Research
- Pregnancy and Medication Impact
- Atherosclerosis and Cardiovascular Diseases
- Transplantation: Methods and Outcomes
- Blood disorders and treatments
Hasselt University
2005-2024
Maastricht University
2010-2022
Maastricht University Medical Centre
2008-2018
RELX Group (United States)
2017
Geneeskundige en Gezondheidsdienst
2014-2015
University Medical Center
2013
Transnational University Limburg
2003-2008
Transnational University Limburg
2007
Summary Memory B cells play a pivotal role in alloreactivity kidney transplantation. Follicular T helper (Tfh) an important the differentiation of into immunoglobulin-producing plasmablasts [through interleukin (IL)-21]. It is unclear to what extent this cell subset regulates humoral transplant patients, therefore we investigated absolute numbers and function peripheral Tfh (CD4POSCXCR5POS cells) patients before after In addition, studied their relationship with presence donor-specific...
Abstract Background Hypoxic-ischemic encephalopathy (HIE) is one of the most important causes brain injury in preterm infants. Preterm HIE predominantly caused by global hypoxia-ischemia (HI). In contrast, focal ischemia common adult and known to result cerebral inflammation activation peripheral immune system. These inflammatory responses are considered play an role adverse outcomes following ischemia. this study, we hypothesize that also involved after HI. Methods instrumented fetal sheep...
Hypoxic-ischemic encephalopathy (HIE) in preterm infants is a severe disease for which no curative treatment available. Cerebral inflammation and invasion of activated peripheral immune cells have been shown to play pivotal role the etiology white matter injury, clinical hallmark HIE infants. The objective this study was assess neuroprotective anti-inflammatory effects intravenously delivered mesenchymal stem (MSC) an ovine model HIE. In translational animal model, global hypoxia-ischemia...
Individual HLA mismatches may differentially impact graft survival after kidney transplantation. Therefore, there is a need for reliable tool to define permissible in We previously demonstrated that donor-derived Predicted Indirectly ReCognizable Epitopes presented by recipient class II (PIRCHE-II) play role de novo DSA formation In the present Dutch multi-center study we evaluated possible association between PIRCHE-II and failure 2,918 donor-recipient couples were transplanted 1995 2005....
Abstract Background Current outbreaks of COVID-19 are threatening the health care systems several countries around world. Control measures, based on isolation, contact tracing, and quarantine, can decrease delay burden ongoing epidemic. With respect to epidemic, recent modeling work shows that these interventions may be inadequate control local outbreaks, even when perfect isolation is assumed. The effect infectiousness prior symptom onset combined with asymptomatic infectees further...
Accumulating evidence indicates that fractionated radiotherapy (RT) can result in distant non-irradiated (abscopal) tumour regression. Although preclinical studies indicate the importance of T cells this infrequent phenomenon, these do not preclude other immune mechanisms exhibit an addition role abscopal effect. We therefore addressed question whether to cell mediated responses also humoral anti-tumour are modulated after RT and systemic dendritic (DC) stimulation enhance tumour-specific...
Outbreaks of SARS-CoV-2 are threatening the health care systems several countries around world. The initial control epidemics relied on non-pharmaceutical interventions, such as social distancing, teleworking, mouth masks and contact tracing. However, pre-symptomatic transmission remains an important driver epidemic, tracing efforts struggle to fully epidemics. Therefore, in this work, we investigate what extent use universal testing, i.e., approach which screen entire population, can be...
Microbiota in the intestinal lumen provide an abundant source of potentially detrimental antigens, including lipopolysaccharide (LPS), a potent immunostimulatory product Gram-negative bacteria recognized by host via TLR-4 and MD-2. An aberrant immune response to LPS or other bacterial antigens has been linked inflammatory bowel disease (IBD) necrotizing enterocolitis (NEC).We investigated which cells express MD-2 normal inflamed ileum from neonates adults immunohistochemistry. Moreover, TLR4...
Abstract In multiple sclerosis (MS), damage to oligodendrocytes is believed be caused by an aberrant immune response initiated autoreactive T cells. Increasing evidence indicates that these cells are not exclusively detrimental but might also exert protective effects. We report for the first time myelin‐reactive T‐cell clones from eight MS patients (6/19) and five healthy controls (4/11) produce leukemia inhibitory factor (LIF), a member of neuropoietic family neurotrophins. addition,...
Abstract Leukemia inhibitory factor (LIF) promotes the survival of oligodendrocytes (OLG) both in vitro and an animal model multiple sclerosis. Here, we show that LIF protects mature rat OLG cultures selectively against combined insult proinflammatory cytokines interferon‐γ tumor necrosis factor‐α, but it does not protect oxidative stress nor staurosporine induced apoptosis. We further demonstrate activates janus kinase (JAK)/signal transducer activator transcription 3 (STAT3)...
Besides their role in destruction of altered self-cells, NK cells have been shown to potentiate T-cell responses by interacting with DC. To take advantage NK-DC crosstalk therapeutic DC-based vaccination for infectious diseases and cancer, it is essential understand the biology this crosstalk. We aimed elucidate vitro mechanisms responsible NK-cell recruitment activation DC during infection. mimic bacterial infection, were exposed a membrane fraction Klebsiella pneumoniae, which triggers...
Abstract Human Leukocyte Antigen ( HLA )‐E is a low‐polymorphic non‐classical class I molecule which plays crucial role in immune surveillance by presentation of peptides to T and natural killer NK ) cells. ‐E polymorphism related surface expression associated with patient outcome after stem cell transplantation. We aim investigate the regulation level peripheral blood mononuclear cells PBMCs healthy individuals homozygous for ‐E*01:01 or ‐E*01:03 , using panel binding derived from CMV Hsp60...
The limited response rate of cancer patients treated with dendritic cell (DC)-based vaccines indicates that vast improvements remain necessary. In many murine tumour models it has been demonstrated the use innate triggers (e.g. TLR triggers) in maturation DC results higher efficacy. However, as few these are generated clinical grade, there remains a great necessity to fill gap between fundamental mouse studies and trial humans. present study we used TLR2/4-agonist (FMKp which is available...
Besides their prominent role in the elimination of infected or malignantly transformed cells, natural killer (NK) cells serve as modulators adaptive immune responses. Enhancing bidirectional crosstalk between NK and dendritic (DC) is considered a promising tool to potentiate cancer vaccines. We investigated what extent direct sensing viral bacterial motifs by contributes response inflammatory DC against same pathogenic stimulus. demonstrated that PAMPs cytokine production via cell-derived...
Chorioamnionitis results from an infection of the fetal membranes and is associated with adverse outcomes notably in intestine. Using a translational ovine model, we showed that intra-amniotic exposure to inflammatory stimuli decreased regulatory/effector T (Treg/Teff) cell balance gut, which was accompanied by intestinal inflammation mucosal injury. We thus aimed augment Treg/Teff ratio gut prophylactic IL-2 treatment evaluate whether it sufficient prevent chorioamnionitis-induced...