A5052949543- Neonatal and fetal brain pathology
- Retinopathy of Prematurity Studies
- Neonatal Respiratory Health Research
- Infant Development and Preterm Care
- Fetal and Pediatric Neurological Disorders
- Anesthesia and Neurotoxicity Research
- Metabolism and Genetic Disorders
- Epilepsy research and treatment
- Neuroscience of respiration and sleep
- Ophthalmology and Visual Impairment Studies
- Antibiotics Pharmacokinetics and Efficacy
- Lysosomal Storage Disorders Research
- Atomic and Subatomic Physics Research
- Tumors and Oncological Cases
- Pharmacological Effects and Toxicity Studies
- Cell Adhesion Molecules Research
- Extracellular vesicles in disease
- Genomics and Rare Diseases
- RNA regulation and disease
- Cleft Lip and Palate Research
- Platelet Disorders and Treatments
- Genetics and Neurodevelopmental Disorders
- Esophageal and GI Pathology
- Retinal Imaging and Analysis
- Renal cell carcinoma treatment
Erasmus MC
2010-2023
Erasmus MC - Sophia Children’s Hospital
2006-2022
University of Helsinki
2022
Semmelweis University
2022
Harvard University
2022
Brigham and Women's Hospital
2022
Helsinki University Hospital
2022
Erasmus University Rotterdam
2013-2015
Boston Children's Hospital
2007
<h3>Objective</h3> To investigate detection ability and feasibility of serial cranial ultrasonography (CUS) early MRI in preterm brain injury. <h3>Design</h3> Prospective cohort study. <h3>Setting</h3> Level III neonatal intensive care unit. <h3>Patients</h3> 307 infants, born below 29 weeks gestation. <h3>Methods</h3> Serial CUS were performed according to standard clinical protocol. In case instability, was postponed or cancelled. Brain images assessed by independent experts compared...
Abstract Objective Isolated agenesis of the corpus callosum on fetal ultrasound has a varied prognosis. Microarray and exome sequencing (ES) might aid in prenatal counseling. Method This study includes 25 fetuses with apparently isolated complete (cACC) ultrasound. All cases were offered single nucleotide polymorphism array. Complementary ES was postnatally selected cases. Clinical physical neurodevelopmental follow‐up collected. Results Eighteen opted for array testing, which detected...
To assess outcome after neonatal perforator stroke in the largest cohort to date.Survivors from a of children diagnosed with using cranial ultrasound or magnetic resonance imaging were eligible for inclusion. Recovery and Recurrence Questionnaire score, presence cerebral palsy (CP), crude assessed, specifically (1) ability walk independently, (2) participation regular education, (3) epilepsy.Thirty-seven patients (20 males, 17 females) aged 3 14 years (mean age 8y) included study: isolated...
Early recognition of seizures in neonates secondary to pathogenic variants potassium or sodium channel coding genes is crucial, as these are often resistant commonly used anti-seizure medications but respond well blockers. Recently, a characteristic ictal amplitude-integrated electroencephalogram (aEEG) pattern was described with KCNQ2-related epilepsy. We report similar aEEG caused by SCN2A- and KCNQ3-pathogenic variants, conventional EEG (cEEG) descriptions.International multicentre...
Abstract Background An increasing number of children are suffering from brain damage-related visual processing dysfunctions (VPD). There is currently a lack evidence-based intervention methods that can be used early in development. We developed protocol suitable 1 year age. The structured, comprehensive and individually adaptive, paired with quantitative outcome assessments. Our aim to investigate the effectiveness this first program for young (a risk of) VPD. Methods This single-blind,...
Introduction: Children with early brain damage or dysfunction are at risk of developing cerebral visual impairment (CVI), including processing dysfunctions (VPD), which currently remain largely undetected until school age. Our aim was to systematically screen for possible VPD in children born very extremely preterm from 1 2 years corrected age (CA) and evaluate the effectiveness referral. Method: We included N = 48 < 30 weeks year CA. They underwent a two-step screening based on (1)...
OBJECTIVE:We assessed the impact of early enteral feeding introduction during therapeutic hypothermia on time to reach full (FEF) and other related outcomes in infants born at ≥35 weeks gestational age diagnosed with moderate severe Hypoxic-Ischemic Encephalopathy.METHODS: A prospective cohort historical control study, conducted admitted Alberta Children's Hospital level III NICU Calgary between January 2013 December 2018.Infants were divided into 2 groups: 1) unfed group (UG), which was...
Abstract Background An increasing amount of children suffer from brain damage-related visual processing dysfunctions (VPD). At present, there is a lack evidence-based intervention methods that can be used early in development. We developed protocol suitable 1 year age. The structured, comprehensive and individually-adaptive paired with quantitative outcome assessments. Our aim to investigate effectiveness this first program for young (a risk of) VPD. Methods conduct single-blind,...
Apneic neonatal seizures can present as apparent life-threatening events. We report a newborn with unexplained episodes of apnea associated cyanosis and desaturation, starting on the first day postpartum. Biochemical tests were normal. Central nervous system infections well abnormalities upper airways cardiovascular excluded. Brain monitoring using amplitude-integrated electroencephalography (aEEG) was inconclusive. Continuous video EEG revealed epileptic originating from left temporal...
Abstract Background An increasing amount of children suffer from brain damage-related visual processing dysfunctions (VPD). At present, there is a lack evidence-based rehabilitation methods that can be used early in development. We developed protocol suitable 1 year age. The contains objective, quantitative outcomes and structured, comprehensive individually-adaptive. Our aim to investigate effectiveness this first program for young with (a risk of) VPD. Methods conduct single-blind,...