A5009816097- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Hemoglobinopathies and Related Disorders
- Chronic Myeloid Leukemia Treatments
- Epigenetics and DNA Methylation
- Platelet Disorders and Treatments
- Erythrocyte Function and Pathophysiology
- RNA modifications and cancer
- Cardiac electrophysiology and arrhythmias
- Oral and Maxillofacial Pathology
- Cardiac Imaging and Diagnostics
- RNA Research and Splicing
- Kruppel-like factors research
- Cardiovascular Function and Risk Factors
- Chronic Lymphocytic Leukemia Research
- Cardiac Arrhythmias and Treatments
- Drug-Induced Adverse Reactions
- Oral and gingival health research
- Reliability and Maintenance Optimization
- Oral Health Pathology and Treatment
- Cardiac pacing and defibrillation studies
- Genomics and Chromatin Dynamics
- Mining Techniques and Economics
- Machine Fault Diagnosis Techniques
- Acute Myeloid Leukemia Research
- Blood donation and transfusion practices
Aristotle University of Thessaloniki
2017-2025
Hospital Clínico San Carlos
2019-2023
KU Leuven
2013-2023
University of Helsinki
2023
Centro Nacional de Biotecnología
2023
Instituto de Investigación Sanitaria del Hospital Clínico San Carlos
2016-2022
Boston University
2022
Boston Area Research Initiative
2022
Northeastern University
2022
Heriot-Watt University
2021-2022
George Patrinos and colleagues report the first implementation of microattribution approach to systematically document genetic variation associated with a disease, applied here hemoglobinopathies thalassemias. They developed series connected locus-specific databases that genotype phenotype information for in 37 globin erythroid protein genes individuals disorders, reciprocal attribution data contributors. We interrelated store all published unpublished related thalassemia implemented...
We report the clinical presentation and risk factors for survival in 175 patients with myeloproliferative neoplasms (MPN) COVID-19, diagnosed between February June 2020. After a median follow-up of 50 days, mortality was higher than general population reached 48% myelofibrosis (MF). Univariate analysis, showed significant relationship death age, male gender, decreased lymphocyte counts, need respiratory support, comorbidities diagnosis MF, while no association essential thrombocythemia (ET),...
It remains unknown whether the presence of coronary microcirculatory dysfunction (CMD) correlates with its equivalent condition in brain, cerebral small vessel disease (CSVD). The cerebral-coronary connection (C3), a prospective blinded study, investigated prevalence CMD patients artery (CAD) and association CSVD cognitive function.Patients documented CAD fulfilling inclusion criteria underwent physiological assessment epicardial vessels microcirculation using intracoronary pressure Doppler....
The JAK2 V617F mutation, the thrombopoietin receptor MPL W515K/L mutation and calreticulin (CALR) mutations are mutually exclusive in essential thrombocythemia support a novel molecular categorization of thrombocythemia. CALR account for approximately 30% cases In retrospective study, we examined frequency V617F-negative (n=103). addition, compared clinical phenotype outcome mutant with cohort V617F-positive (n=57). CALR-positive represented 63.7% double-negative thrombocythemia, most...
Abstract In a multicenter European retrospective study including 162 patients with COVID-19 occurring in essential thrombocythemia (ET, n = 48), polycythemia vera (PV, 42), myelofibrosis (MF, 56), and prefibrotic (pre-PMF, 16), 15 major thromboses (3 arterial 12 venous) were registered 14 patients, of whom all, but one, receiving LMW-heparin prophylaxis. After adjustment for the competing risk death, cumulative incidence venous thromboembolic events (VTE) reached 8.5% after 60 days...
Background and Clinical Significance: Lipomas, benign tumors composed of adipose tissue, are recognized as one the two most common fat-containing soft tissue tumors, underscoring their relative prevalence among in children. Despite prominence, lipomas rarely occur before 20 years age, highlighting a discrepancy between commonality age at which they typically manifest. This case report focuses on 11-year-old patient who noticed presence an intraoral mass, prompted further investigation,...
Background/Aim: Peripheral ossifying fibroma (POF) constitutes a common reactive lesion of the gingiva, most commonly localized in anterior maxillary region. Non-neoplastic, originates from periodontal ligament response to chronically injurious factors related tissues, such as dental calculus, plaque, and orthodontic appliances. The aim this case report is illustrate emergence POF 46-year-old female patient with severe generalized periodontitis. Case Report: A came our clinic, complaining...
Background/Aim: Macrolides belong to the very often used antibiotics. However, macrolides are recognized as antibiotics that possibly linked development of Stevens-Johnson syndrome (SJS) and Toxic Epidermal Necrolysis (TEN). SJS TEN (SJS/TEN) uncommon, life-threatening, potentially fatal hypersensitivity mucocutaneous reactions may affect oral mucosa well. The aim this case report refers illustration macrolide induced in a 58-years-old male patient. Case Report: A patient presented himself,...
Platelets are key players in hemostasis and thrombosis. Essential thrombocythemia (ET) is a myeloproliferative neoplasm (MPN) which the JAK2 V617F, MPL W515K/L, CALR mutations determine differences clinical phenotype, particular thrombotic risk of myelofibrosis. Here, we examined proteome platelets ET by mass spectrometry (MS) combination with functional assays to gain insights into platelet activation ET. MS analysis revealed different stoichiometric mitochondrial proteins compared normal...
FINDbase (http://www.findbase.org) aims to document frequencies of clinically relevant genomic variations, namely causative mutations and pharmacogenomic markers, worldwide. Each database record includes the population, ethnic group or geographical region, disorder name related gene, accompanied by links any databases genetic variation together with its frequency in that population. Here, we report, addition regular data content updates, significant developments FINDbase, visualization...
Platelet concentrates (PCs) represent a blood transfusion product with major concern for safety as their storage temperature (20–24°C) allows bacterial growth, and maximum time period (less than week) precludes complete microbiological testing. Pathogen inactivation technologies (PITs) provide an additional layer of to the products from known unknown pathogens such bacteria, viruses, parasites. In this context, PITs, Mirasol Reduction Technology (PRT), have been developed are implemented in...
Introduction: The silencing of death-associated protein kinase 1 (DAPK-1) is an effective way inactivating a tumor-suppressing mechanism. aim this study was to investigate the immunohistochemical expression DAPK-1 in oral leukoplakia (OL) and squamous cell carcinoma (OSCC). Methods: (IHC) detection carried out cases OLs OSCCs. molecules' tissue distribution OLs/OSCCs tissues evaluated using semiquantitative immunohistochemistry representative paraffin-embedded samples (57 total) from...
Background and clinical significance: Polymorphous adenocarcinoma of the oral cavity is predominantly located in palate. It characterized by a slow rate growth thus may be misdiagnosed as benign tumor. Its histology intricate with other salivary malignancies, necessitating specific immunohistochemical stains. Our case report illustrates an localized palate 61-year-old female patient. Case presentation: The patient came to postgraduate clinic Oral Medicine Pathology, Department School...
The use of platelets as biomaterials has gained intense research interest. However, the mechanisms regarding platelet-mediated skeletal myogenesis remain to be established. aim this study was determine role platelet releasate in and muscle stem cell fate vitro ex vivo respectively.We analysed effect on proliferation differentiation C2C12 myoblasts by means assays, immunohistochemistry, gene expression bioenergetics. We expanded findings single fibres determining murine cells using protein...
Increasing attention has been directed towards identifying non-T-cell mechanisms as potential therapeutic targets in rheumatoid arthritis. Synovial fibroblast (SF) activation, a hallmark of arthritis, results inappropriate production chemokines and matrix components, which turn lead to bone cartilage destruction. We have demonstrated that SFs an autonomous pathogenic role the development disease, by showing they capacity migrate throughout body cause pathology specifically joints. In order...
The rapid increase in scale and sophistication of offshore wind (OSW) farms poses a critical challenge related to the cost-effective operation management energy assets. A defining characteristic this is economic trade-off between two concomitant processes: power production (the primary driver short-term revenues), asset degradation main determinant long-term expenses). Traditionally, approaches optimize maintenance have been conducted isolation. In article, we conjecture that joint...
The ordered assembly of a functional preinitiation complex (PIC), composed general transcription factors (GTFs), is prerequisite for the protein-coding genes by RNA polymerase II. TFIID, comprised TATA binding protein (TBP) and 13 TBP-associated (TAFs), GTF that thought to recognize promoter sequences allowing site-specific PIC assembly. Transcriptional cofactors, such as SAGA, are also necessary tightly regulated initiation. contribution two TAF10-containing complexes (TFIID, SAGA)...