A5071267690- Growth Hormone and Insulin-like Growth Factors
- Pituitary Gland Disorders and Treatments
- Adipokines, Inflammation, and Metabolic Diseases
- Systemic Lupus Erythematosus Research
- Orthopedic Infections and Treatments
- Hormonal Regulation and Hypertension
- Peroxisome Proliferator-Activated Receptors
- HIV/AIDS drug development and treatment
- Cytokine Signaling Pathways and Interactions
- Cardiovascular Disease and Adiposity
- Orthopaedic implants and arthroplasty
- Cholesterol and Lipid Metabolism
- Health Literacy and Information Accessibility
- Polyomavirus and related diseases
- Platelet Disorders and Treatments
- Rheumatoid Arthritis Research and Therapies
- Endometrial and Cervical Cancer Treatments
- Lipid metabolism and disorders
- Autoimmune and Inflammatory Disorders Research
- Ovarian function and disorders
- Full-Duplex Wireless Communications
- Blood Coagulation and Thrombosis Mechanisms
- Hepatitis C virus research
- Diet and metabolism studies
- Cardiovascular Issues in Pregnancy
Elisabeth-TweeSteden Ziekenhuis
2017-2018
Amsterdam UMC Location University of Amsterdam
2009-2016
University of Amsterdam
2009-2016
Amphia Ziekenhuis
2015
Université Paris Cité
2014
Délégation Paris 5
2014
Waterlandziekenhuis
2011-2012
Tergooi
2011-2012
University of Insubria
2010
Leiden University Medical Center
2010
Abstract Prolactin is best known as the polypeptide anterior pituitary hormone, which regulates development of mammary gland. However, it became clear over last decade that prolactin contributes to a broad range pathologies, including breast cancer. also involved in angiogenesis via release pro‐angiogenic factors by leukocytes and epithelial cells. whether influences endothelial cells, there are functional consequences prolactin‐induced signalling perspective angiogenesis, remains so far...
The aim of this trial was to determine whether obese patients benefit from treatment with rimonabant in terms progression carotid atherosclerosis. Rimonabant, a selective cannabinoid-1 receptor blocker, reduces body weight and improves cardiometabolic risk factors who are obese.A prospective, double-blind, placebo-controlled (Atherosclerosis Underlying Development assessed by Intima-media Thickness On Rimonabant (AUDITOR)) randomised 661 abdominal obesity metabolic syndrome or placebo for 30...
The aim of this verification study was to compare the QuantiFERON®-TB Gold Plus (QFT-Plus) In Tube (QFT-GIT). new QFT-Plus test contains an extra antigen tube which, according manufacturer additionally elicits a CD8+ T-cell response above CD4+ response. We assessed value in detecting recent latent tuberculosis infections.Between May 2015 and December 2016, 1031 subjects underwent QFT-GIT test. Overall agreement between both tests performance for different indications and/or immune states...
Prolactin is increasingly recognized to play a stimulatory role in the inflammatory response. Because inflammation considered of crucial importance development atherosclerosis, we aimed evaluate whether prolactin levels are associated with occurrence coronary artery disease (CAD).We performed nested case-control study prospective EPIC-Norfolk cohort. Cases were apparently healthy men and women, aged 45 79 years, who developed fatal or nonfatal CAD (n=882). Controls remained free (n=1490)....
Atherosclerotic vascular disease is the consequence of a chronic inflammatory process, and prolactin has been shown to be component response. Additionally, recent studies indicate that contributes an atherogenic phenotype. We hypothesized this may result direct effect on atherogenesis through activation receptor. Human carotid atherosclerotic plaques were obtained from patients by endarteriectomies. The mRNA receptor, but not prolactin, was detected in these quantitative real-time PCR. In...
Prolactin (PRL) is a lactation-inducing hormone with immunomodulatory properties and found at elevated levels in the serum of patients RA other rheumatic diseases. The PRL receptor (PRLR) has been shown to be expressed by macrophages atherosclerotic plaques. aim this study was examine PRLR expression synovial its role regulation macrophage activation.Serum monomeric 23 kDa were measured 119 using fluoroimmunometric assay. assessed tissue 91 RA, 15 PsA 8 OA immunohistochemistry digital image...
Summary Platelets play an important role in the development of plaque formation and events after rupture atherosclerotic plaque, leading to atherothrombosis. Multiple hormones, either excess or when deficient, are involved atherothrombotic disease, but, which extent such hormones affect platelet function, is still controversial. It was objective this study assess ability pituitary hormone prolactin functions. Venous blood collected from six healthy males. Platelet activation studied by (i)...
Objective— Several acquired risk factors for venous thrombosis (VT) are associated with high prolactin levels. Our goal was to investigate VT different levels of prolactin. Methods and Results— We used data a case-control study on leg vein conducted between September 1999 August 2006 at the Academic Medical Center, Amsterdam, Netherlands. Prolactin assessed in 187 cases (mean age, 57 years; range, 19 90) 374 gender-matched controls 18 93). Odds ratios 95% CI were estimated based several...
Atherothrombosis is a multifactorial process, governed by an interaction between the vessel wall, hemodynamic factors and systemic atherothrombotic risk factors. Recent in vitro, human ex vivo animal studies have implicated hormone prolactin as mediator. To address this issue, we evaluated anatomy function of various microvascular beds well plasma atherothrombosis markers patients with elevated levels. In pilot study, involving 10 prolactinoma control subjects, sidestream dark field (SDF)...
The pituitary-derived hormone prolactin has been suggested to stimulate the development of atherosclerosis and cardiovascular disease through its effects on metabolism inflammation. In this study, we aimed challenge hypothesis that inhibition function may beneficially affect burden. Hereto, atherosclerosis-susceptible LDL receptor (Ldlr) knockout mice were transplanted with bone marrow from transgenic expressing pure antagonist Del1-9-G129R-hPRL or their non-transgenic littermates as...
Prolactin may contribute to an atherogenic phenotype. Furthermore, previous studies have shown that prolactin levels increase in situations of acute stress and inflammation. We therefore aimed investigate the relationship between prolactin, inflammation patients with myocardial infarction. performed a case-control study 40 infarction 39 controls, aged 41–84 years. Blood for assessment high sensitive C-reactive protein (hsCRP) was drawn at inclusion, is, during phase event, 2–3 weeks later....
Evaluation of 16S PCR in addition to the standard culture improve pathogen detection rate clinical specimens.Microbiological and direct was performed on specimens from suspected prosthetic joint infection patients (cohort-1) tissues fluids other normally sterile body sites (cohort-2). Based microbiological data, for both methods assessed, assuming no superiority either or culture. In cohort-1, 469 were obtained. Culture positive 170 (36·2%) specimens, detected 70 (41·2%) those pathogens....
Antipsychotic drugs have been shown to modulate the expression of ATP-binding cassette transporter A1 (ABCA1), a key factor in anti-atherogenic reverse cholesterol transport process, vitro. Here we evaluated potential typical antipsychotic drug haloperidol efflux function macrophages vitro and their susceptibility atherosclerosis vivo.Thioglycollate-elicited peritoneal were used for studies. Hyperlipidaemic low-density lipoprotein (LDL) receptor knockout mice implanted with...
<h3>Background and objective</h3> Rheumatoid arthritis (RA) is a rheumatic disease mainly affecting women. Prolactin (PRL) sex hormone, which apart from inducing lactation, has also immunomodulatory properties. High prolactin levels are associated with an increased activity postpartum some studies have shown that bromocriptin, decreasing levels, improves clinical of patients RA. Furthermore, hyperprolactinemia observed in 6% RA compared to 3% the normal population. Recently, receptor (PRLR),...
Cardiovascular diseases (CVDs) account for approximately 30% of all deaths globally. The most important cause CVD is atherothrombosis, in other words, narrowing the arteries as a result deposition cholesterol and lipoid substances within arterial wall. Several endocrine disorders have been linked to this pathological state. Recent clinical experimental studies suggested that prolactin, pleiotropic pituitary hormone, may potentially contribute CVD, either through direct modulation local...